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  4. Recombinant Human Contactin-4 (CNTN4), partial

Recombinant Human Contactin-4 (CNTN4), partial

  • 中文名稱：
    Recombinant Human Contactin-4(CNTN4) ,partial
  • 貨號：
    CSB-YP810284HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human Contactin-4(CNTN4) ,partial
  • 貨號：
    CSB-EP810284HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human Contactin-4(CNTN4) ,partial
  • 貨號：
    CSB-EP810284HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human Contactin-4(CNTN4) ,partial
  • 貨號：
    CSB-BP810284HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human Contactin-4(CNTN4) ,partial
  • 貨號：
    CSB-MP810284HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    AXCAM; Axonal associated cell adhesion molecule; BIG 2; BIG-2; Brain derived immunoglobulin superfamily protein 2; Brain-derived immunoglobulin superfamily protein 2; Cntn4; CNTN4_HUMAN; CNTN4A; contactin 4; Contactin-4; Neural cell adhesion protein BIG 2; SCA16
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity. May be involved in synaptogenesis.
  • 基因功能參考文獻：
    1. High CNTN4 expression is associated with Pheochromocytomas and Paragangliomas. PMID: 28938490
    2. Association between contactin 4 (CNTN4) and antisaccade and P300 in schizophrenia. PMID: 27995817
    3. SNPs within the CNTN4 gene are associated with increased risk of oral cancer. PMID: 28595731
    4. SNPs in ITPR1 and CNTN4 are involved in the regulation of serum uric acid concentrations in Mexican Americans PMID: 27039371
    5. By combining methylation and SNP data, CNTN4 was identified as a risk factor for regular alcohol use. PMID: 26146898
    6. data reveal critical and novel roles for CNTN4/amyloid precursor protein in promoting target-specific axon arborization PMID: 25959733
    7. We identified CNTN4 as a novel candidate gene for POAG. PMID: 24764060
    8. these results suggest that rare copy number variations in CNTN4 may also influence autism susceptibility in Asian populations. PMID: 22750301
    9. Using array comparative genome hybridization (CGH), we identified a maternally inherited approximately 535 kb deletion at 3p26.3 encompassing the 5' end of the contactin 4 gene (CNTN4) in a patient with autism. PMID: 21308999
    10. Our results demonstrate the association of CNTN4 disruption with the 3p deletion syndrome phenotype and strongly suggest a causal relationship PMID: 15106122
    11. The contactin 4 gene (CNTN4) is associated with cerebellar degeneration in spinocerebellar ataxia type 16. Additional studies are necessary to prove 4,256C-->T to be a causative mutation. PMID: 17030759
    12. pathological examinations and molecular biological examinations are needed to confirm that this mutation is a true cause of SCA16 PMID: 17915252
    13. This report suggests that mutations affecting CNTN4 function may be relevant to Autism spectrum disorder pathogenesis. PMID: 18349135
    14. results do not support the candidacy of CHL1, CNTN6, and CNTN4 as tumor suppressor genes in the 3p26-pter region in ovarian cancer PMID: 19509545

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  • 相關疾病：
    A chromosomal aberration involving CNTN4 has been found in a boy with characteristic physical features of 3p deletion syndrome (3PDS). Translocation t(3;10)(p26;q26). 3PDS is a rare contiguous gene disorder involving the loss of the telomeric portion of the short arm of chromosome 3 and characterized by developmental delay, growth retardation, and dysmorphic features.
  • 亞細胞定位：
    Cell membrane; Lipid-anchor, GPI-anchor. Secreted.
  • 蛋白家族：
    Immunoglobulin superfamily, Contactin family
  • 組織特異性：
    Mainly expressed in brain. Highly expressed in cerebellum and weakly expressed in corpus callosum, caudate nucleus, amygdala and spinal cord. Also expressed in testis, pancreas, thyroid, uterus, small intestine and kidney. Not expressed in skeletal muscle
  • 數據庫鏈接：

    HGNC: 2174

    OMIM: 607280

    KEGG: hsa:152330

    STRING: 9606.ENSP00000380602

    UniGene: Hs.298705



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