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  4. CNTN4 Antibody

CNTN4 Antibody

  • 中文名稱：
    CNTN4兔多克隆抗體
  • 貨號：
    CSB-PA007480
  • 規格：
    ￥1090
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    AXCAM antibody; Axonal associated cell adhesion molecule antibody; BIG 2 antibody; BIG-2 antibody; Brain derived immunoglobulin superfamily protein 2 antibody; Brain-derived immunoglobulin superfamily protein 2 antibody; Cntn4 antibody; CNTN4_HUMAN antibody; CNTN4A antibody; contactin 4 antibody; Contactin-4 antibody; Neural cell adhesion protein BIG 2 antibody; SCA16 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human Contactin 4.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    IF, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    IF 1:200-1:1000
    ELISA 1:20000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity. May be involved in synaptogenesis.
  • 基因功能參考文獻：
    1. High CNTN4 expression is associated with Pheochromocytomas and Paragangliomas. PMID: 28938490
    2. Association between contactin 4 (CNTN4) and antisaccade and P300 in schizophrenia. PMID: 27995817
    3. SNPs within the CNTN4 gene are associated with increased risk of oral cancer. PMID: 28595731
    4. SNPs in ITPR1 and CNTN4 are involved in the regulation of serum uric acid concentrations in Mexican Americans PMID: 27039371
    5. By combining methylation and SNP data, CNTN4 was identified as a risk factor for regular alcohol use. PMID: 26146898
    6. data reveal critical and novel roles for CNTN4/amyloid precursor protein in promoting target-specific axon arborization PMID: 25959733
    7. We identified CNTN4 as a novel candidate gene for POAG. PMID: 24764060
    8. these results suggest that rare copy number variations in CNTN4 may also influence autism susceptibility in Asian populations. PMID: 22750301
    9. Using array comparative genome hybridization (CGH), we identified a maternally inherited approximately 535 kb deletion at 3p26.3 encompassing the 5' end of the contactin 4 gene (CNTN4) in a patient with autism. PMID: 21308999
    10. Our results demonstrate the association of CNTN4 disruption with the 3p deletion syndrome phenotype and strongly suggest a causal relationship PMID: 15106122
    11. The contactin 4 gene (CNTN4) is associated with cerebellar degeneration in spinocerebellar ataxia type 16. Additional studies are necessary to prove 4,256C-->T to be a causative mutation. PMID: 17030759
    12. pathological examinations and molecular biological examinations are needed to confirm that this mutation is a true cause of SCA16 PMID: 17915252
    13. This report suggests that mutations affecting CNTN4 function may be relevant to Autism spectrum disorder pathogenesis. PMID: 18349135
    14. results do not support the candidacy of CHL1, CNTN6, and CNTN4 as tumor suppressor genes in the 3p26-pter region in ovarian cancer PMID: 19509545

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  • 相關疾病：
    A chromosomal aberration involving CNTN4 has been found in a boy with characteristic physical features of 3p deletion syndrome (3PDS). Translocation t(3;10)(p26;q26). 3PDS is a rare contiguous gene disorder involving the loss of the telomeric portion of the short arm of chromosome 3 and characterized by developmental delay, growth retardation, and dysmorphic features.
  • 亞細胞定位：
    Cell membrane; Lipid-anchor, GPI-anchor. Secreted.
  • 蛋白家族：
    Immunoglobulin superfamily, Contactin family
  • 組織特異性：
    Mainly expressed in brain. Highly expressed in cerebellum and weakly expressed in corpus callosum, caudate nucleus, amygdala and spinal cord. Also expressed in testis, pancreas, thyroid, uterus, small intestine and kidney. Not expressed in skeletal muscle
  • 數據庫鏈接：

    HGNC: 2174

    OMIM: 607280

    KEGG: hsa:152330

    STRING: 9606.ENSP00000380602

    UniGene: Hs.298705



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