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  4. Recombinant Human Contactin-1 (CNTN1), partial

Recombinant Human Contactin-1 (CNTN1), partial

  • 中文名稱：
    Recombinant Human Contactin-1(CNTN1) ,partial
  • 貨號：
    CSB-YP623657HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human Contactin-1(CNTN1) ,partial
  • 貨號：
    CSB-EP623657HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human Contactin-1(CNTN1) ,partial
  • 貨號：
    CSB-EP623657HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human Contactin-1(CNTN1) ,partial
  • 貨號：
    CSB-BP623657HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human Contactin-1(CNTN1) ,partial
  • 貨號：
    CSB-MP623657HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    CNTN 1; CNTN; Cntn1; CNTN1_HUMAN; Contactin-1; Contactin1; F3; F3cam; Glycoprotein gp135; gp 135; GP135; MYPCN; Neural cell surface protein F3
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 表達區域：
    -
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Interaction with TNR induces a repulsion of neurons and an inhibition of neurite outgrowth.
  • 基因功能參考文獻：
    1. CNTN1 promotes growth, metastasis and invasion of Hs578T breast cancer cell line. PMID: 29673312
    2. Proteolipid protein 1 and contactin 1 gene variation modulates interhemispheric integration PMID: 27864734
    3. CNTN-1 promotes cisplatin resistance in human cisplatin-resistant lung adenocarcinoma through inducing the Epithelial-Mesenchymal Transition process by activating the PI3K/Akt signaling pathway. PMID: 28934754
    4. CNTN1 is a new gene which can be regulated by RET/PTC3 (Ret proto-oncogene and Ret-activating protein ELE1) rearrangement gene and the protein level of CNTN1 is increasing in thyroid cancer. PMID: 26722434
    5. Structurally, CASPR2 is highly glycosylated and has an overall compact architecture. CASPR2 associates with micromolar affinity with CNTN1 but, under the same conditions, it does not interact with any of the other members of the contactin family. PMID: 26721881
    6. CNTN1 promotes prostate cancer progression. PMID: 26795349
    7. High CNTN-1 expression is associated with metastasis in gastric cancer. PMID: 25952582
    8. CNTN-1 is closely related with multidrug resistance of lung adenocarcinoma. PMID: 25960233
    9. anti-CNTN1 IgG4 antibodies are associated with subacute onset of chronic inflammatory demyelinating polyneuropathy symptoms, sensory ataxia, and good response to corticosteroids. PMID: 25808373
    10. under hypoxia conditions, elevated HIF-1alpha seems to up-regulate contactin-1 expression and by this activate RhoA and facilitate migration of cancer cells. PMID: 25916117
    11. a completely novel function for F3/Contactin - modulator of neurogenesis PMID: 22360968
    12. A high expression of CNTN1 was markedly associated with the regional lymph node metastasis of patients with oral squamous cell carcinoma. PMID: 22580838
    13. The expression of CNTN-1 is upregulated in esophageal squamous cell carcinoma tissue and is related to stage and lymphatic invasion. Thus, it may be involved in the pathogenesis & progression of esophageal squamous cell carcinoma. PMID: 22581910
    14. Data revealed that knockdown of VEGFR-3 with the shRNA lentiviral vector resulted in down-regulation of the downstream neural cell adhesion molecule contactin-1 (CNTN-1). PMID: 21805024
    15. report the cocrystal structure of the carbonic anhydrase-like domain of PTPRZ bound to tandem Ig repeats of CNTN1 and binding assays to show that PTPRZ binds specifically to CNTN1 expressed at the surface of oligodendrocyte precursor cells PMID: 21969550
    16. VEGF-C mediated biological function through transcription of CNTN-1, which is implicated in tumor invasion and metastasis. PMID: 21482472
    17. F3 acts as a functional ligand for Notch during oligodendrocyte maturation. PMID: 14567914
    18. The repulsive properties of contactin may be a key factor in glioma disaggregation, and may contribute to the diffuse infiltration pattern characteristic of glioma cells in human brain. PMID: 16078236
    19. Contactin-1 is proposed to function importantly in the invasion and metastasis of lung adenocarcinoma cells via RhoA-mediated mechanisms. PMID: 16510572
    20. Mutations in CNTN1, a neural adhesion molecule and neuromuscular junction protein, cause a familial form of lethal congenital myopathy. PMID: 19026398

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  • 相關疾病：
    Myopathy, congenital, Compton-North (MYPCN)
  • 亞細胞定位：
    [Isoform 1]: Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side.; [Isoform 2]: Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side.
  • 蛋白家族：
    Immunoglobulin superfamily, Contactin family
  • 組織特異性：
    Strongly expressed in brain and in neuroblastoma and retinoblastoma cell lines. Lower levels of expression in lung, pancreas, kidney and skeletal muscle.
  • 數據庫鏈接：

    HGNC: 2171

    OMIM: 600016

    KEGG: hsa:1272

    STRING: 9606.ENSP00000325660

    UniGene: Hs.143434



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