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  4. Recombinant Human Conserved oligomeric Golgi complex subunit 5 (COG5), partial

Recombinant Human Conserved oligomeric Golgi complex subunit 5 (COG5), partial

In Stock
  • 貨號：
    CSB-EP890771HU
  • 規(guī)格：
    ￥1836
  • 圖片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

產(chǎn)品詳情

  • 純度：
    Greater than 90% as determined by SDS-PAGE.
  • 基因名：
    COG5
  • Uniprot No.：
  • 別名：
    (COG complex subunit 5)(13S Golgi transport complex 90 kDa subunit)(GTC-90)(Component of oligomeric Golgi complex 5)(Golgi transport complex 1)
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 來源：
    E.coli
  • 分子量：
    33.8 kDa
  • 表達(dá)區(qū)域：
    1-257aa
  • 氨基酸序列
    MGWVGGRRRDSASPPGRSRSAADDINPAPANMEGGGGSVAVAGLGARGSGAAAATVRELLQDGCYSDFLNEDFDVKTYTSQSIHQAVIAEQLAKLAQGISQLDRELHLQVVARHEDLLAQATGIESLEGVLQMMQTRIGALQGAVDRIKAKIVEPYNKIVARTAQLARLQVACDLLRRIIRILNLSKRLQGQLQGGSREITKAAQSLNELDYLSQGIDLSGIEVIENDLLFIARARLEVENQAKRLLEQGLETQNPT
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標(biāo)簽：
    N-terminal 10xHis-tagged
  • 產(chǎn)品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    3-7 business days
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能：
    Required for normal Golgi function.
  • 基因功能參考文獻(xiàn)：
    1. Targeted silencing of components of lobe B of the COG complex, namely COG5, COG6, COG7 and COG8, inhibited HIV-1 replication PMID: 25179963
    2. Cog5-Cog7 crystal structure reveals interactions essential for the function of a multisubunit tethering complex. PMID: 25331899
    3. In conclusion, we find that GDF5, but not COG5 or MCF2L, influence the extent of radiographic damage in knee osteoarthritis PMID: 22615457
    4. Report on a uterine leiomyoma with a novel HMGA2 fusion gene in a 44-year-old woman. PMID: 20804914
    5. Sec34 is implicated in traffic from the endoplasmic reticulum to the Golgi and exists in a complex with GTC-90 and ldlBp PMID: 11929878
    6. COG5- and COG7 subunits play distinctive roles in controlling Golgi structure and function PMID: 16051600

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  • 相關(guān)疾?。?/div>
    Congenital disorder of glycosylation 2I (CDG2I)
  • 亞細(xì)胞定位：
    Cytoplasm, cytosol. Golgi apparatus membrane; Peripheral membrane protein.
  • 蛋白家族：
    COG5 family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 14857

    OMIM: 606821

    KEGG: hsa:10466

    STRING: 9606.ENSP00000297135

    UniGene: Hs.239631



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