在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Connector enhancer of kinase suppressor of ras 1 (CNKSR1)

Recombinant Human Connector enhancer of kinase suppressor of ras 1 (CNKSR1)

  • 中文名稱：
    Recombinant Human Connector enhancer of kinase suppressor of ras 1(CNKSR1)
  • 貨號(hào)：
    CSB-YP005652HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human Connector enhancer of kinase suppressor of ras 1(CNKSR1)
  • 貨號(hào)：
    CSB-EP005652HU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human Connector enhancer of kinase suppressor of ras 1(CNKSR1)
  • 貨號(hào)：
    CSB-EP005652HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human Connector enhancer of kinase suppressor of ras 1(CNKSR1)
  • 貨號(hào)：
    CSB-BP005652HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    CNKSR1
  • Uniprot No.：
  • 別名：
    CNK; CNK homolog protein 1; CNK1; CNKR1_HUMAN; CNKSR1; Connector enhancer of kinase suppressor of ras 1; Connector enhancer of KSR 1; Connector enhancer of KSR like; Connector enhancer of KSR-like; Connector enhancer of KSR1; hCNK1; KSR
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    full length protein
  • 表達(dá)區(qū)域：
    1-720
  • 氨基酸序列
    MEPVETWTPG KVATWLRGLD DSLQDYPFED WQLPGKNLLQ LCPQSLEALA VRSLGHQELI LGGVEQLQAL SSRLQTENLQ SLTEGLLGAT HDFQSIVQGC LGDCAKTPID VLCAAVELLH EADALLFWLS RYLFSHLNDF SACQEIRDLL EELSQVLHED GPAAEKEGTV LRICSHVAGI CHNILVCCPK ELLEQKAVLE QVQLDSPLGL EIHTTSNCQH FVSQVDTQVP TDSRLQIQPG DEVVQINEQV VVREERDMVG WPRKNMVREL LREPAGLSLV LKKIPIPETP PQTPPQVLDS PHQRSPSLSL APLSPRAPSE DVFAFDLSSN PSPGPSPAWT DSASLGPEPL PIPPEPPAIL PAGVAGTPGL PESPDKSPVG RKKSKGLATR LSRRRVSCRE LGRPDCDGWL LLRKAPGGFM GPRWRRRWFV LKGHTLYWYR QPQDEKAEGL INVSNYSLES GHDQKKKYVF QLTHDVYKPF IFAADTLTDL SMWVRHLITC ISKYQSPGRA PPPREEDCYS ETEAEDPDDE AGSHSASPSP AQAGSPLHGD TSPAATPTQR SPRTSFGSLT DSSEEALEGM VRGLRQGGVS LLGQPQPLTQ EQWRSSFMRR NRDPQLNERV HRVRALQSTL KAKLQELQVL EEVLGDPELT GEKFRQWKEQ NRELYSEGLG AWGVAQAEGS SHILTSDSTE QSPHSLPSDP EEHSHLCPLT SESSLRPPDL
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    May function as an adapter protein or regulator of Ras signaling pathways.
  • 基因功能參考文獻(xiàn)：
    1. CNKSR1 expression is increased in pancreatic cancer specimens and was found to be an independent prognostic marker of overall survival. PMID: 28732488
    2. Data indicate connector enhancer of kinase suppressor of Ras 1 protein (CNK1) as a molecular platform that controls c-raf protein (RAF) and c-akt protein (AKT) signalling and determines cell fate decisions in a cell type- and cell stage-dependent manner. PMID: 27901111
    3. The findings reveal SAM domain-dependent oligomerization by AKT as a switch for CNK1 activation. PMID: 27769899
    4. tyrosine phosphorylation is an important mechanism to control the subcellular localization of CNK1 and its distinct biological functions. PMID: 26319181
    5. CNK1 mediates ephrinB1 signaling that promotes cell migration through RhoA and JNK activity. PMID: 24825906
    6. Studies indicate that CNK1-driven proliferation relies on Akt-dependent phosphorylation and inactivation of FoxO proteins. PMID: 21320536
    7. These findings identify CNK1 as a new positive regulator of insulin signaling. PMID: 20634316
    8. Thus, CNK1 is an essential mediator of an oncogenic pathway involved in invasion of breast and cervical cancer cells and is therefore a putative target for cancer therapy. PMID: 20197385
    9. CNK1 promotes oncogenic signalling through Akt in breast cancer cell lines and tumours. PMID: 20383191
    10. hCNK1 associates with Rhophilin and RalGDS, Rho and Ras effector molecules, respectively, suggesting that it acts as a scaffold protein to mediate cross talk between the two pathways PMID: 14749388
    11. Data show that the connector enhancer of KSR 1 scaffold protein, through its binding of a RASSF1A/MST1 complex, participates in the proapoptotic signaling initiated by active Ras. PMID: 15075335
    12. CNK1 couples a subset of Rho exchange factors to activation of the JNK MAP kinase pathway and that signaling specificity is achieved through complexes containing both upstream activators and downstream targets of Rho. PMID: 15753034
    13. CNK1 allows cross-talk between Src and Raf-1 and is essential for the full activation of Raf-1 PMID: 15845549
    14. CNK1 binds through the sterile alpha motif (SAM) and the conserved region in CNK (CRIC) to the AT2 receptor. CNK1 may play a role in the AT2 receptor-mediated signaling pathways. PMID: 16289034
    15. DC-SIGN was constitutively associated with a signalosome complex consisting of the scaffold proteins LSP1, KSR1 and CNK and the kinase Raf-1. PMID: 19718030

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Cytoplasm. Membrane; Peripheral membrane protein.
  • 蛋白家族：
    CNKSR family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 19700

    OMIM: 603272

    KEGG: hsa:10256

    STRING: 9606.ENSP00000354609

    UniGene: Hs.16232



主站蜘蛛池模板： 在线成人精品国产区免费| 东北老女人高潮大喊舒服死了 | 国内精品视频一区二区三区 | 内射视频←www夜| 国产乱女乱子视频在线播放 | 日本肉体xxxx裸交| 中文字幕婷婷日韩欧美亚洲| 波多野结av在线无码中文| 99久久99久久精品免费观看 | 亚洲精品伦理熟女国产一区二区| 国产md视频一区二区三区| 18禁成人网站免费观看| 一本久久a久久精品综合| 最近高清中文在线字幕在线观看1| 丰满人妻被黑人连续中出| 国产欧美一区二区三区在线看| 成年免费视频黄网站在线观看| a v 在线视频 亚洲免费| 午夜不卡无码中文字幕影院| xx性欧美肥妇精品久久久久久| 国产日韩av无码免费一区二区 | 日韩v亚洲v欧美v精品综合| 国产日韩一区二区三免费高清| 中文字幕人成乱码熟女香港| 成人精品免费视频在线观看| 人妻换人妻a片爽麻豆| 国产98色在线 | 日韩| 蜜桃无码一区二区三区| 国产亚洲福利在线视频| 精品无码久久久久国产app | 少妇精品无码一区二区三区| 午夜福利18以下勿进免费| 欧美 日韩 亚洲 精品二区| 亚洲精品一区| 免费女人高潮流视频在线| 蜜臀少妇人妻在线| 手机福利视频| 久久久亚洲欧洲日产国码606| 亚洲精品在看在线观看| 丰满少妇人妻无码专区| 国产人妻鲁鲁一区二区|