在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Connector enhancer of kinase suppressor of ras 1 (CNKSR1)

Recombinant Human Connector enhancer of kinase suppressor of ras 1 (CNKSR1)

  • 中文名稱：
    Recombinant Human Connector enhancer of kinase suppressor of ras 1(CNKSR1)
  • 貨號(hào)：
    CSB-YP005652HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human Connector enhancer of kinase suppressor of ras 1(CNKSR1)
  • 貨號(hào)：
    CSB-EP005652HU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human Connector enhancer of kinase suppressor of ras 1(CNKSR1)
  • 貨號(hào)：
    CSB-EP005652HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human Connector enhancer of kinase suppressor of ras 1(CNKSR1)
  • 貨號(hào)：
    CSB-BP005652HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    CNKSR1
  • Uniprot No.：
  • 別名：
    CNK; CNK homolog protein 1; CNK1; CNKR1_HUMAN; CNKSR1; Connector enhancer of kinase suppressor of ras 1; Connector enhancer of KSR 1; Connector enhancer of KSR like; Connector enhancer of KSR-like; Connector enhancer of KSR1; hCNK1; KSR
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    full length protein
  • 表達(dá)區(qū)域：
    1-720
  • 氨基酸序列
    MEPVETWTPG KVATWLRGLD DSLQDYPFED WQLPGKNLLQ LCPQSLEALA VRSLGHQELI LGGVEQLQAL SSRLQTENLQ SLTEGLLGAT HDFQSIVQGC LGDCAKTPID VLCAAVELLH EADALLFWLS RYLFSHLNDF SACQEIRDLL EELSQVLHED GPAAEKEGTV LRICSHVAGI CHNILVCCPK ELLEQKAVLE QVQLDSPLGL EIHTTSNCQH FVSQVDTQVP TDSRLQIQPG DEVVQINEQV VVREERDMVG WPRKNMVREL LREPAGLSLV LKKIPIPETP PQTPPQVLDS PHQRSPSLSL APLSPRAPSE DVFAFDLSSN PSPGPSPAWT DSASLGPEPL PIPPEPPAIL PAGVAGTPGL PESPDKSPVG RKKSKGLATR LSRRRVSCRE LGRPDCDGWL LLRKAPGGFM GPRWRRRWFV LKGHTLYWYR QPQDEKAEGL INVSNYSLES GHDQKKKYVF QLTHDVYKPF IFAADTLTDL SMWVRHLITC ISKYQSPGRA PPPREEDCYS ETEAEDPDDE AGSHSASPSP AQAGSPLHGD TSPAATPTQR SPRTSFGSLT DSSEEALEGM VRGLRQGGVS LLGQPQPLTQ EQWRSSFMRR NRDPQLNERV HRVRALQSTL KAKLQELQVL EEVLGDPELT GEKFRQWKEQ NRELYSEGLG AWGVAQAEGS SHILTSDSTE QSPHSLPSDP EEHSHLCPLT SESSLRPPDL
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    May function as an adapter protein or regulator of Ras signaling pathways.
  • 基因功能參考文獻(xiàn)：
    1. CNKSR1 expression is increased in pancreatic cancer specimens and was found to be an independent prognostic marker of overall survival. PMID: 28732488
    2. Data indicate connector enhancer of kinase suppressor of Ras 1 protein (CNK1) as a molecular platform that controls c-raf protein (RAF) and c-akt protein (AKT) signalling and determines cell fate decisions in a cell type- and cell stage-dependent manner. PMID: 27901111
    3. The findings reveal SAM domain-dependent oligomerization by AKT as a switch for CNK1 activation. PMID: 27769899
    4. tyrosine phosphorylation is an important mechanism to control the subcellular localization of CNK1 and its distinct biological functions. PMID: 26319181
    5. CNK1 mediates ephrinB1 signaling that promotes cell migration through RhoA and JNK activity. PMID: 24825906
    6. Studies indicate that CNK1-driven proliferation relies on Akt-dependent phosphorylation and inactivation of FoxO proteins. PMID: 21320536
    7. These findings identify CNK1 as a new positive regulator of insulin signaling. PMID: 20634316
    8. Thus, CNK1 is an essential mediator of an oncogenic pathway involved in invasion of breast and cervical cancer cells and is therefore a putative target for cancer therapy. PMID: 20197385
    9. CNK1 promotes oncogenic signalling through Akt in breast cancer cell lines and tumours. PMID: 20383191
    10. hCNK1 associates with Rhophilin and RalGDS, Rho and Ras effector molecules, respectively, suggesting that it acts as a scaffold protein to mediate cross talk between the two pathways PMID: 14749388
    11. Data show that the connector enhancer of KSR 1 scaffold protein, through its binding of a RASSF1A/MST1 complex, participates in the proapoptotic signaling initiated by active Ras. PMID: 15075335
    12. CNK1 couples a subset of Rho exchange factors to activation of the JNK MAP kinase pathway and that signaling specificity is achieved through complexes containing both upstream activators and downstream targets of Rho. PMID: 15753034
    13. CNK1 allows cross-talk between Src and Raf-1 and is essential for the full activation of Raf-1 PMID: 15845549
    14. CNK1 binds through the sterile alpha motif (SAM) and the conserved region in CNK (CRIC) to the AT2 receptor. CNK1 may play a role in the AT2 receptor-mediated signaling pathways. PMID: 16289034
    15. DC-SIGN was constitutively associated with a signalosome complex consisting of the scaffold proteins LSP1, KSR1 and CNK and the kinase Raf-1. PMID: 19718030

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Cytoplasm. Membrane; Peripheral membrane protein.
  • 蛋白家族：
    CNKSR family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 19700

    OMIM: 603272

    KEGG: hsa:10256

    STRING: 9606.ENSP00000354609

    UniGene: Hs.16232



主站蜘蛛池模板： 99精品视频在线观看免费| 麻花传媒剧国产mv高清播放| 久久久久四虎精品免费入口| 无码精品人妻一区二区三区98| 把插八插露脸对白内射| 日韩激情无码不卡码| 国产精品视频白浆免费视频| 国产日产欧产精品精品ai| 国产精品美女久久久久久福利| 2021亚洲国产成a在线| 夜夜高潮夜夜爽国产伦精品 | 成人国产精品一区二区免费看| 中文无码乱人伦中文视频在线v| 快好爽射给我视频| 92午夜少妇极品福利无码电影| 暴力强奷在线播放无码| 性xxxx18免费观看视频| 性欧美丰满熟妇xxxx性久久久 | 亚洲人成人无码网www国产| 天堂网www在线资源最新版| 午夜无码国产理论在线| 国产乱子夫妻xx黑人xyx真爽| _97夜夜澡人人爽人人喊_欧美| 99久久精品国产一区二区| 亚洲欧美成aⅴ人在线观看| 国语对白做受xxxxx在线中国 | 欧美性大战久久久久久久| 日韩人妻无码免费视频一二区| 免费很黄无遮挡的视频| 男女作爱免费网站| 国产96在线 | 韩国| 亚洲日韩国产精品无码av| 国产一区二区三区在线观看| 国产精品卡一卡二卡三| 天天躁日日躁aaaxxⅹ| 人人人妻人人人妻人人人| 鲁大师影院在线观看| 中国女人大白屁股ass| 潮喷失禁大喷水av无码| 最新av偷拍av偷窥av网站| 大战熟女丰满人妻av|