在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

CNKSR1 Antibody

  • 中文名稱:
    CNKSR1兔多克隆抗體
  • 貨號:
    CSB-PA005652GA01HU
  • 規(guī)格:
    ¥3,900
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
    CNKSR1
  • 別名:
    CNK antibody; CNK homolog protein 1 antibody; CNK1 antibody; CNKR1_HUMAN antibody; CNKSR1 antibody; Connector enhancer of kinase suppressor of ras 1 antibody; Connector enhancer of KSR 1 antibody; Connector enhancer of KSR like antibody; Connector enhancer of KSR-like antibody; Connector enhancer of KSR1 antibody; hCNK1 antibody; KSR antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human CNKSR1
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA,WB,IHC
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能:
    May function as an adapter protein or regulator of Ras signaling pathways.
  • 基因功能參考文獻(xiàn):
    1. CNKSR1 expression is increased in pancreatic cancer specimens and was found to be an independent prognostic marker of overall survival. PMID: 28732488
    2. Data indicate connector enhancer of kinase suppressor of Ras 1 protein (CNK1) as a molecular platform that controls c-raf protein (RAF) and c-akt protein (AKT) signalling and determines cell fate decisions in a cell type- and cell stage-dependent manner. PMID: 27901111
    3. The findings reveal SAM domain-dependent oligomerization by AKT as a switch for CNK1 activation. PMID: 27769899
    4. tyrosine phosphorylation is an important mechanism to control the subcellular localization of CNK1 and its distinct biological functions. PMID: 26319181
    5. CNK1 mediates ephrinB1 signaling that promotes cell migration through RhoA and JNK activity. PMID: 24825906
    6. Studies indicate that CNK1-driven proliferation relies on Akt-dependent phosphorylation and inactivation of FoxO proteins. PMID: 21320536
    7. These findings identify CNK1 as a new positive regulator of insulin signaling. PMID: 20634316
    8. Thus, CNK1 is an essential mediator of an oncogenic pathway involved in invasion of breast and cervical cancer cells and is therefore a putative target for cancer therapy. PMID: 20197385
    9. CNK1 promotes oncogenic signalling through Akt in breast cancer cell lines and tumours. PMID: 20383191
    10. hCNK1 associates with Rhophilin and RalGDS, Rho and Ras effector molecules, respectively, suggesting that it acts as a scaffold protein to mediate cross talk between the two pathways PMID: 14749388
    11. Data show that the connector enhancer of KSR 1 scaffold protein, through its binding of a RASSF1A/MST1 complex, participates in the proapoptotic signaling initiated by active Ras. PMID: 15075335
    12. CNK1 couples a subset of Rho exchange factors to activation of the JNK MAP kinase pathway and that signaling specificity is achieved through complexes containing both upstream activators and downstream targets of Rho. PMID: 15753034
    13. CNK1 allows cross-talk between Src and Raf-1 and is essential for the full activation of Raf-1 PMID: 15845549
    14. CNK1 binds through the sterile alpha motif (SAM) and the conserved region in CNK (CRIC) to the AT2 receptor. CNK1 may play a role in the AT2 receptor-mediated signaling pathways. PMID: 16289034
    15. DC-SIGN was constitutively associated with a signalosome complex consisting of the scaffold proteins LSP1, KSR1 and CNK and the kinase Raf-1. PMID: 19718030

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Cytoplasm. Membrane; Peripheral membrane protein.
  • 蛋白家族:
    CNKSR family
  • 數(shù)據(jù)庫鏈接:

    HGNC: 19700

    OMIM: 603272

    KEGG: hsa:10256

    STRING: 9606.ENSP00000354609

    UniGene: Hs.16232



主站蜘蛛池模板: 强伦姧人妻免费无码电影| 无码国产伦一区二区三区视频| 无码av波多野结衣| 国产精品久久久久久麻豆一区| 亚洲中文字幕伊人久久无码| 99热在线精品国产观看| 在线亚洲人成电影网站色www| 久久精品久久电影免费理论片 | 久久久久77777人人人人人| 人妻老妇乱子伦精品无码专区| 欧美精品色婷婷五月综合| 午夜久久久久久禁播电影| 亚洲人成无码网www电影麻豆| 欧美变态另类牲交| 欧美精品色婷婷五月综合| 欧洲成人一区二区三区| 国产精品人妻久久毛片| 在线精品视频一区二区三四| 漂亮人妻被中出中文字幕| 加勒比一本heyzo高清视频| 一本一本久久a久久综合精品蜜桃 国产精品人妻久久毛片高清无卡 成视频年人黄网站视频福利 | 亚洲精品无码精品mv在线观看| 精品人妻少妇一区二区| 97se亚洲国产综合自在线观看| 日本久久高清一区二区三区毛片| 精品国产电影久久九九| 国产精品激情av久久久青桔| 国产亚洲日韩在线三区| 无码中文字幕免费一区二区三区| 亚洲成a人无码| 久久精品国产99久久久古代| 亚洲亚洲熟妇色l图片20p| 亚洲熟女av乱码在线观看漫画| 亚洲日韩欧美国产高清αv| 国产无遮挡又黄又爽又色| 国产精品久久久久7777按摩| 小草社区视频在线观看| 国产亚洲成av人片在线观黄桃 | 永久免费的av在线电影网 | 亚洲国产av一区二区三区四区| 国产午夜福利在线播放|