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  4. Recombinant Human Condensin-2 complex subunit D3 (NCAPD3), partial

Recombinant Human Condensin-2 complex subunit D3 (NCAPD3), partial

  • 中文名稱：
    人NCAPD3重組蛋白
  • 貨號：
    CSB-YP015515HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人NCAPD3重組蛋白
  • 貨號：
    CSB-EP015515HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人NCAPD3重組蛋白
  • 貨號：
    CSB-EP015515HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人NCAPD3重組蛋白
  • 貨號：
    CSB-BP015515HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人NCAPD3重組蛋白
  • 貨號：
    CSB-MP015515HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    NCAPD3
  • Uniprot No.：
  • 別名：
    CAP D3; CAPD 3; CAPD3; CNDD3_HUMAN; Condensin II complex subunit D3; Condensin-2 complex subunit D3; FLJ42888; hCAP-D3; Hcp 6; Hcp6; hHCP 6; hHCP6; KIAA0056; MGC104671; NCAPD 3; Ncapd3; Non SMC condensin II complex subunit D3; Non-SMC condensin II complex subunit D3; OTTHUMP00000235403; OTTHUMP00000235404
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis. May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Specifically required for decatenation of centromeric ultrafine DNA bridges during anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size.
  • 基因功能參考文獻：
    1. Condensin II(CAP-D3 and CAP-H2) and GAIT subunits associate with L1 RNA in a co-dependent manner, independent of IFN-gamma. These findings suggest that cooperation between the Condensin II and GAIT complexes may facilitate a novel mechanism of L1 repression, thus contributing to the maintenance of genome stability in somatic cells PMID: 29028794
    2. CAP-D3 down-regulates transcription of genes that encode amino acid transporters (SLC7A5 and SLC3A2) to promote bacterial autophagy by colon epithelial cells. PMID: 25701737
    3. The initial phase of chromosome condensation requires Cdk1-mediated phosphorylation of the CAP-D3 subunit of condensin II. PMID: 21498573
    4. hCAP-D3 is a new biomarker for subtype-1 prostate tumors that improves prognostication. PMID: 18223322
    5. We show here that protein phosphatase 2A (PP2A), which interacts with condensin II but not condensin I, plays an essential role in targeting condensin II to chromosomes. PMID: 19915589
    6. The CAP-D3 subunit of the condensin II complex implicated in chromosome assembly and segeregation PMID: 14532007

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  • 亞細胞定位：
    Nucleus.
  • 數據庫鏈接：

    HGNC: 28952

    OMIM: 609276

    KEGG: hsa:23310

    STRING: 9606.ENSP00000433681

    UniGene: Hs.438550



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