在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Collectin-11 (COLEC11)

Recombinant Human Collectin-11 (COLEC11)

  • 中文名稱：
    Recombinant Human Collectin-11(COLEC11)
  • 貨號：
    CSB-YP861154HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human Collectin-11(COLEC11)
  • 貨號：
    CSB-EP861154HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human Collectin-11(COLEC11)
  • 貨號：
    CSB-EP861154HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human Collectin-11(COLEC11)
  • 貨號：
    CSB-BP861154HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    COLEC11
  • Uniprot No.：
  • 別名：
    CL K1; CL K1 I; CL K1 II; CL K1 IIa; CL K1 IIb; CL-K1; CLK1; COL11_HUMAN; COLEC 11; COLEC11; Collectin 11; Collectin kidney I; Collectin kidney protein 1; Collectin sub family member 11; Collectin-11; Collectin11; DKFZp686N1868; MGC129470; MGC129471; MGC3279
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區域：
    26-271
  • 氨基酸序列
    QPAGD DACSVQILVP GLKGDAGEKG DKGAPGRPGR VGPTGEKGDM GDKGQKGSVG RHGKIGPIGS KGEKGDSGDI GPPGPNGEPG LPCECSQLRK AIGEMDNQVS QLTSELKFIK NAVAGVRETE SKIYLLVKEE KRYADAQLSC QGRGGTLSMP KDEAANGLMA AYLAQAGLAR VFIGINDLEK EGAFVYSDHS PMRTFNKWRS GEPNNAYDEE DCVEMVASGG WNDVACHTTM YFMCEFDKEN M
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Lectin that plays a role in innate immunity, apoptosis and embryogenesis. Calcium-dependent lectin that binds self and non-self glycoproteins presenting high mannose oligosaccharides with at least one terminal alpha-1,2-linked mannose epitope. Primarily recognizes the terminal disaccharide of the glycan. Also recognizes a subset of fucosylated glycans and lipopolysaccharides. Plays a role in innate immunity through its ability to bind non-self sugars presented by microorganisms and to activate the complement through the recruitment of MAPS1. Also plays a role in apoptosis through its ability to bind in a calcium-independent manner the DNA present at the surface of apoptotic cells and to activate the complement in response to this binding. Finally, plays a role in development, probably serving as a guidance cue during the migration of neural crest cells and other cell types during embryogenesis.
  • 基因功能參考文獻：
    1. this study demonstrates the role of CL-11 and the molecular mechanisms involved in modulating retinal pigment epithelial cell phagocytosis and cytokine production PMID: 28772263
    2. High CLK1 expression is associated with cardiovascular disease. PMID: 27341702
    3. The exclusion of the MASP1 and COLEC11 Loci in two individuals from different consanguineous families and the absence of mutations in four further individuals sequenced for both genes raises the possibility that that there is further genetic heterogeneity of 3MC syndrome PMID: 26789649
    4. identify collectin CL-LK as a novel soluble C-type lectin able to bind M. tuberculosis, and characterize mycobacterial mannose-capped lipoarabinomannan as a primary ligand for CL-LK PMID: 26173080
    5. Data indicate differences in the plasma concentrations of collectin liver 1 and collectin kidney 1, M-ficolin and H-ficol in systemic lupus erythematosus (SLE) patients compared to a group of healthy controls. PMID: 26154564
    6. promoter polymorphism COLEC11-9570C>T (rs3820897) was associated with decreased levels of CL-K1. PMID: 25710878
    7. the sugar specificity of CL-K1 was established. PMID: 25912189
    8. These results suggest that specific diseases may affect CL-K1 synthesis in an organ dependent manner and that elevated plasma CL-K1 levels are associated with the presence of DIC. PMID: 24474086
    9. Most plasma CL-K1 was found in complex with CL-L1 in a ratio suggesting a heteromeric subunit of 1 CL-L1 & 2 CL-K1 polypeptides. It associated with MASPs 1, 2 & 3. On binding mannan or DNA in the presence of MASP-2, the complex deposited C4b. PMID: 24174618
    10. Data suggest that collectin 11 (CL-11), e.g. via complement, may play a role in response to particles and surfaces presenting extracellular DNA, such as apopototic cells. PMID: 23954398
    11. collectin-11 associates with all the known MBL-associated serine proteases (MASP-1, MASP-2 and MASP-3) as well as the lectin complement pathway regulator MAP-1. PMID: 23220946
    12. Data show that the concentration of collectin kidney 1 (CL-K1, COLEC11) in plasma was 0.34 +/- 0.13 microg/ml and that in mannan-binding lectin (MBL) was 1.72 +/- 1.51 microg/ml. PMID: 21893516
    13. these findings demonstrate a role for complement pathway factors in fundamental developmental processes and in the etiology of 3MC syndrome. PMID: 21258343
    14. CL-11 plays a role in activation of the complement system and in the defense against invading microorganisms PMID: 20956340

    顯示更多

    收起更多

  • 相關疾病：
    3MC syndrome 2 (3MC2)
  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    COLEC10/COLEC11 family
  • 組織特異性：
    Ubiquitous. Detected in adrenal gland, kidney, liver, ovaries and testis (at protein level).
  • 數據庫鏈接：

    HGNC: 17213

    OMIM: 265050

    KEGG: hsa:78989

    STRING: 9606.ENSP00000339168

    UniGene: Hs.32603



主站蜘蛛池模板： 午夜男女无遮掩免费视频| 香蕉免费一区二区三区在| 99热成人精品热久久6网站| 亚洲视频高清不卡在线观看| 午夜dj在线观看高清在线视频完整版| 国产一性一交一伦一a片| 国产98在线 | 日韩| 国产美女a做受大片观看| 国产在线乱子伦一区二区| 免费裸体美女网站| 国产婷婷一区二区三区| 成年网站未满十八禁视频天堂| 亚洲精品色情app在线下载观看| 午夜视频体内射.com.com| 久久精品中文无码资源站| 9l国产精品久久久久麻豆| 日韩欧美亚洲综合久久影院| 野外做受又硬又粗又大视频| 亚洲国产精品久久久天堂麻豆宅男| 亚洲国产精品久久久久网站| 国产日韩av免费无码一区二区三区| 国内精品国产三级国产av| 电影内射视频免费观看| 日本一卡二卡3卡四卡网站精品| 精品香蕉一区二区三区| 日韩av无码久久一区二区| 亚洲欧美v国产一区二区| 免费无码一区二区三区蜜桃| 久久久亚洲欧洲日产国产成人无码| 亚洲国产成人精品福利| 成人国产一区二区精品小说| 国产精品久久久久久久久ktv| 四虎国产精品永久在线国在线| 四虎国产精品永久在线无码| 中国6一12呦女精品| 国产人妻人伦精品1国产 | 欧美综合自拍亚洲图久青草| 久9热视频这里只精品18| 国产精品免费一区二区三区四区 | 永久免费无码av网站在线观看| 成人精品视频一区二区三区|