在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

COLEC11 Antibody

  • 中文名稱:
    COLEC11兔多克隆抗體
  • 貨號:
    CSB-PA861154ESR2HU
  • 規格:
    ¥3900
  • 圖片:
    • Western blot
      All lanes: COLEC11 antibody at 4μg/ml + Rat liver tissue
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 29, 27, 22, 30, 25, 24, 31 kDa
      Observed band size: 29 kDa
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA861154ESR2HU at dilution of 1:100
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) COLEC11 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    COLEC11
  • 別名:
    CL K1 antibody; CL K1 I antibody; CL K1 II antibody; CL K1 IIa antibody; CL K1 IIb antibody; CL-K1 antibody; CLK1 antibody; COL11_HUMAN antibody; COLEC 11 antibody; COLEC11 antibody; Collectin 11 antibody; Collectin kidney I antibody; Collectin kidney protein 1 antibody; Collectin sub family member 11 antibody; Collectin-11 antibody; Collectin11 antibody; DKFZp686N1868 antibody; MGC129470 antibody; MGC129471 antibody; MGC3279 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human, Rat
  • 免疫原:
    Recombinant Human Collectin-11 protein (26-271AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, WB, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Lectin that plays a role in innate immunity, apoptosis and embryogenesis. Calcium-dependent lectin that binds self and non-self glycoproteins presenting high mannose oligosaccharides with at least one terminal alpha-1,2-linked mannose epitope. Primarily recognizes the terminal disaccharide of the glycan. Also recognizes a subset of fucosylated glycans and lipopolysaccharides. Plays a role in innate immunity through its ability to bind non-self sugars presented by microorganisms and to activate the complement through the recruitment of MAPS1. Also plays a role in apoptosis through its ability to bind in a calcium-independent manner the DNA present at the surface of apoptotic cells and to activate the complement in response to this binding. Finally, plays a role in development, probably serving as a guidance cue during the migration of neural crest cells and other cell types during embryogenesis.
  • 基因功能參考文獻:
    1. this study demonstrates the role of CL-11 and the molecular mechanisms involved in modulating retinal pigment epithelial cell phagocytosis and cytokine production PMID: 28772263
    2. High CLK1 expression is associated with cardiovascular disease. PMID: 27341702
    3. The exclusion of the MASP1 and COLEC11 Loci in two individuals from different consanguineous families and the absence of mutations in four further individuals sequenced for both genes raises the possibility that that there is further genetic heterogeneity of 3MC syndrome PMID: 26789649
    4. identify collectin CL-LK as a novel soluble C-type lectin able to bind M. tuberculosis, and characterize mycobacterial mannose-capped lipoarabinomannan as a primary ligand for CL-LK PMID: 26173080
    5. Data indicate differences in the plasma concentrations of collectin liver 1 and collectin kidney 1, M-ficolin and H-ficol in systemic lupus erythematosus (SLE) patients compared to a group of healthy controls. PMID: 26154564
    6. promoter polymorphism COLEC11-9570C>T (rs3820897) was associated with decreased levels of CL-K1. PMID: 25710878
    7. the sugar specificity of CL-K1 was established. PMID: 25912189
    8. These results suggest that specific diseases may affect CL-K1 synthesis in an organ dependent manner and that elevated plasma CL-K1 levels are associated with the presence of DIC. PMID: 24474086
    9. Most plasma CL-K1 was found in complex with CL-L1 in a ratio suggesting a heteromeric subunit of 1 CL-L1 & 2 CL-K1 polypeptides. It associated with MASPs 1, 2 & 3. On binding mannan or DNA in the presence of MASP-2, the complex deposited C4b. PMID: 24174618
    10. Data suggest that collectin 11 (CL-11), e.g. via complement, may play a role in response to particles and surfaces presenting extracellular DNA, such as apopototic cells. PMID: 23954398
    11. collectin-11 associates with all the known MBL-associated serine proteases (MASP-1, MASP-2 and MASP-3) as well as the lectin complement pathway regulator MAP-1. PMID: 23220946
    12. Data show that the concentration of collectin kidney 1 (CL-K1, COLEC11) in plasma was 0.34 +/- 0.13 microg/ml and that in mannan-binding lectin (MBL) was 1.72 +/- 1.51 microg/ml. PMID: 21893516
    13. these findings demonstrate a role for complement pathway factors in fundamental developmental processes and in the etiology of 3MC syndrome. PMID: 21258343
    14. CL-11 plays a role in activation of the complement system and in the defense against invading microorganisms PMID: 20956340

    顯示更多

    收起更多

  • 相關疾病:
    3MC syndrome 2 (3MC2)
  • 亞細胞定位:
    Secreted.
  • 蛋白家族:
    COLEC10/COLEC11 family
  • 組織特異性:
    Ubiquitous. Detected in adrenal gland, kidney, liver, ovaries and testis (at protein level).
  • 數據庫鏈接:

    HGNC: 17213

    OMIM: 265050

    KEGG: hsa:78989

    STRING: 9606.ENSP00000339168

    UniGene: Hs.32603



主站蜘蛛池模板: 国产+成+人+亚洲欧洲自线| 亚洲精品国产嫩草在线观看东京热 | 国产精品女同一区二区在线| 国产精品高潮呻吟av久久黄| 精品少妇爆乳无码av无码专区| 少女韩国电视剧在线观看完整| 51社区精品视频| 无码人妻丝袜视频在线播免费| 内射人妻无码色ab麻豆| 国产亚洲精品aaaa片app| 日韩a无v码在线播放| 国产欧美一区二区精品仙草咪| 亚洲蜜桃v妇女| 国产精品久久毛片av大全日韩| 永久黄网站免费视频性色| 99热网址最新获取域名| 欧美xxxxx精品| 人妻少妇被猛烈进入中文字幕| 国产福利姬喷水福利在线观看| 动漫精品中文无码卡通动漫| 国产一线二线三线女| 一本一道精品欧美中文字幕| 亚洲熟妇av一区二区三区宅男| 国产精品免费看久久久无码 | 99精品国产在热久久无码| 蜜臀色欲av在线播放国产日韩 | 美女视频黄频a美女大全| 久久久久久a亚洲欧洲av| 国内无遮挡18禁无码网站免费| 97av麻豆蜜桃一区二区| 成人天堂婷婷青青视频在线观看 | 香蕉人妻av久久久久天天| 中国农村妇女真实bbwbbwbbw| 国产又黄又刺激又高潮的网站| 黑人大群体交免费视频| 波多野结衣av一区二区全免费观看| 日本国产成人国产在线播放| 国产精品亚洲专区无码破解版| 无码人妻精品一区二区在线视频| 精品日产卡一卡二卡麻豆| 久久www免费人成看片入口|