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  4. Recombinant Human Collagen alpha-1 (IX) chain (COL9A1), partial

Recombinant Human Collagen alpha-1 (IX) chain (COL9A1), partial

  • 中文名稱：
    Recombinant Human Collagen alpha-1(IX) chain(COL9A1) ,partial
  • 貨號(hào)：
    CSB-YP005757HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human Collagen alpha-1(IX) chain(COL9A1) ,partial
  • 貨號(hào)：
    CSB-EP005757HU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human Collagen alpha-1(IX) chain(COL9A1) ,partial
  • 貨號(hào)：
    CSB-EP005757HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human Collagen alpha-1(IX) chain(COL9A1) ,partial
  • 貨號(hào)：
    CSB-BP005757HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human Collagen alpha-1(IX) chain(COL9A1) ,partial
  • 貨號(hào)：
    CSB-MP005757HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    COL9A1Collagen alpha-1(IX) chain
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Structural component of hyaline cartilage and vitreous of the eye.
  • 基因功能參考文獻(xiàn)：
    1. the COL9A1 rs35470562 variant may contribute to congenital talipes equinovarus susceptibility in the Chinese population examined. PMID: 27819742
    2. We observed a significant association between rs6910140 of COL9A1 and KBD, suggesting a role of COL9A1 in the development of KBD. PMID: 25774918
    3. The study demonstrated that hypermethylation is associated with down-regulation of COL9A1 expression in osteoarthritic (OA) cartilage and highlights the pivotal role of epigenetics in OA. PMID: 25048791
    4. The NC2 domain of type IX collagen determines the chain composition but also the chain register of the triple helix. PMID: 23132862
    5. Type IX collagen interacts with fibronectin providing an important molecular bridge in articular cartilage PMID: 21768108
    6. A second, novel mutation was identified in COL9A1, causing autosomal recessive Stickler syndrome together with the previously described nucleotide change in two separate families. PMID: 21421862
    7. COL9A1 protein is highly expressed in patients with idiopathic congenital talipes equinovarus (ICTEV) and rs1135056, which is located in the coding region of COL9A1 gene, may be associated with the pathogenesis of ICTEV. PMID: 21672422
    8. NC2 domain of collagen IX provides chain selection and heterotrimerization PMID: 20507993
    9. This study extends the range of gene-mutations that can cause multiple epiphyseal dysplasia-related myopathy. PMID: 20358595
    10. Data show that the proximal-promoter region of the human COL9A1 gene can drive expression of a reporter gene in chondrocytic RCS cells, but not in nonchondrocytic cell lines. PMID: 12399468
    11. the amino-terminal NC4 domain of human collagen IX interacts with glycosaminoglycans and cartilage oligomeric matrix protein PMID: 15047691
    12. COMP, type IX collagen and MATN3 play important roles in matrix assembly PMID: 15694129
    13. A search of the microRNA database revealed a highly conserved target sequence for miR-9 immediately preceding the overlapping polyadenylation signals in the novel 3' UTR of COL9A1, suggesting its role in posttranscriptional regulation of COL9A1. PMID: 16718610
    14. COL9A1 is the fourth identified gene that can cause Stickler syndrome. PMID: 16909383
    15. analysis of the crystal structure of the N-terminal NC4 domain of collagen IX PMID: 17553797
    16. the matrilin-3 A-domain appears to bind exclusively to the COL3 domain of type IX collagen and this binding is abolished in the presence of a disease causing mutation in type IX collagen PMID: 17881354
    17. mutation causes multiple epiphyseal dysplasia; genetic heterogeneity PMID: 11565064

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  • 相關(guān)疾病：
    Multiple epiphyseal dysplasia 6 (EDM6); Stickler syndrome 4 (STL4)
  • 亞細(xì)胞定位：
    Secreted, extracellular space, extracellular matrix.
  • 蛋白家族：
    Fibril-associated collagens with interrupted helices (FACIT) family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 2217

    OMIM: 120210

    KEGG: hsa:1297

    STRING: 9606.ENSP00000349790

    UniGene: Hs.590892



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