在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Cohesin subunit SA-1 (STAG1), partial

  • 中文名稱:
    人STAG1重組蛋白
  • 貨號:
    CSB-YP855483HU
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    人STAG1重組蛋白
  • 貨號:
    CSB-EP855483HU
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    人STAG1重組蛋白
  • 貨號:
    CSB-EP855483HU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人STAG1重組蛋白
  • 貨號:
    CSB-BP855483HU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人STAG1重組蛋白
  • 貨號:
    CSB-MP855483HU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    Cohesin subunit SA 1; Cohesin subunit SA-1; Cohesin Subunit SA1; Nuclear protein stromal antigen 1; SA 1; SCC 3 homolog 1; Scc3; SCC3 homolog 1; STAG 1; stag1; STAG1_HUMAN; Stromal antigen 1
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Partial
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis.
  • 基因功能參考文獻:
    1. The SNP but not wild-type had profound alterations in SA-1 expression with miR-29b inhibitor. PMID: 29471289
    2. Here the authors demonstrate that the most frequently mutated subunit of the cohesin complex, STAG2, displays a strong synthetic lethal interaction with its paralog STAG1. Mechanistically, STAG1 loss abrogates sister chromatid cohesion in STAG2 mutated but not in wild-type cells leading to mitotic catastrophe, defective cell division and apoptosis. PMID: 28691904
    3. This first series reporting the phenotype ascribed to mutation in STAG1 highlights the importance of data sharing in the field of rare disorders. PMID: 28119487
    4. Data indicate that cohesin subunit SA-1 (STAG1) is a promising therapeutic target in cancers with inactivating alterations of cohesin subunit SA-2 (STAG2). PMID: 28430577
    5. There is LOH at STAG1 and STAG2 loci in oral squamous cell carcinoma (OSCC), but OSCC and NM showed similar transcriptional levels of STAG1, STAG2, and PDS5B. PMID: 27341316
    6. Data support the hypothesis that CTCF and cohesin SA-1 have multiple roles in the regulation of gene expression during erythropoiesis. PMID: 27219007
    7. TRF1 tethers SA1 within telomeric regions that SA1 transiently interacts with. SA1 and TRF1 together form longer DNA-DNA pairing tracts than with TRF1 alone, as revealed by atomic force microscopy imaging PMID: 27298259
    8. Nuclear import and export signals of human cohesins SA1/STAG1 and SA2/STAG2 expressed in Saccharomyces cerevisiae. PMID: 22715410
    9. Mutations in STAG1 is associated with acute myeloid leukemia. PMID: 24335498
    10. cohesin-SA1 and cohesin-SA2 participate in the DNA damage response PMID: 24324008
    11. Rad21 binds to SA proteins through two SA-binding motifs on Rad21. PMID: 23874961
    12. STAG1, a novel transcriptional target for p53, mediates p53-dependent apoptosis, and might be a good candidate for next-generation gene therapy in cancer. PMID: 15361841
    13. STAG1 (Scc3/SA1) subunit of cohesin interacts with the CCTC-binding factor CTCF bound to the c-myc insulator element. PMID: 18550811
    14. cohesin(SA1) and cohesin(SA2) are differentially required for telomere and centromere cohesion, respectively. PMID: 19822671

    顯示更多

    收起更多

  • 相關疾病:
    Mental retardation, autosomal dominant 47 (MRD47)
  • 亞細胞定位:
    Nucleus. Chromosome. Chromosome, centromere. Note=Associates with chromatin. Before prophase it is scattered along chromosome arms. During prophase, most of cohesin complexes dissociate from chromatin probably because of phosphorylation by PLK1, except at centromeres, where cohesin complexes remain. At anaphase, the RAD21 subunit of cohesin is cleaved, leading to the dissociation of the complex from chromosomes, allowing chromosome separation.
  • 蛋白家族:
    SCC3 family
  • 數據庫鏈接:

    HGNC: 11354

    OMIM: 604358

    KEGG: hsa:10274

    STRING: 9606.ENSP00000372689

    UniGene: Hs.412586



主站蜘蛛池模板: 亚洲人成人网站色www| 熟妇人妻无码中文字幕| 乱色精品无码一区二区国产盗| 天天做天天躁天天躁| 成人亚洲欧美久久久久| 亚洲乱码在线卡一卡二卡新区| 欧美肥老太交性506070| 6080yyy午夜理论片中无码| 国产免费一区二区三区免费视频| 久久久国产99久久国产久麻豆 | 无码国产午夜福利片在线观看 | 亚洲成av人片不卡无码| 成人3d动漫一区二区三区| 久久综合a∨色老头免费观看| 亚洲v天堂v手机在线| 亚洲精品国产精品国自产| 亚洲大乳高潮日本专区| 欧美自拍亚洲综合丝袜| 精品卡一卡二卡3卡高清乱码 | 亚洲成av人影院| 无码人妻精品一区二区三区久久久| 久草热8精品视频在线观看| 天天摸天天做天天添欧美| 艳妇荡女欲乱双飞两中年熟妇| 乱色精品无码一区二区国产盗| 久久精品农村毛片| 丰满的少妇邻居中文bd | 国产成人精品一区二区秒播| 久久综合九色综合久99| 国产极品美女到高潮| 最近高清中文在线字幕在线观看1| 大伊香蕉精品视频在线| 一本一道波多野结衣av黑人| 青青青草国产线观| 免费1级做爰片在线观看爱| 啦啦啦www播放日本观看| 日韩欧美一中文字暮专区| 美女粉嫩饱满的一线天mp4| 好爽又高潮了毛片免费下载| 国产精品美女一区二区视频| 久久国产精品萌白酱免费|