在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Cation transport regulator-like protein 1 (CHAC1)

  • 中文名稱:
    Recombinant Human Cation transport regulator-like protein 1(CHAC1)
  • 貨號:
    CSB-YP883606HU
  • 規(guī)格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    Recombinant Human Cation transport regulator-like protein 1(CHAC1)
  • 貨號:
    CSB-EP883606HU
  • 規(guī)格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    Recombinant Human Cation transport regulator-like protein 1(CHAC1)
  • 貨號:
    CSB-EP883606HU-B
  • 規(guī)格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    Recombinant Human Cation transport regulator-like protein 1(CHAC1)
  • 貨號:
    CSB-BP883606HU
  • 規(guī)格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    Recombinant Human Cation transport regulator-like protein 1(CHAC1)
  • 貨號:
    CSB-MP883606HU
  • 規(guī)格:
  • 來源:
    Mammalian cell
  • 其他:

產(chǎn)品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    CHAC1
  • Uniprot No.:
  • 別名:
    Blocks Notch protein; Botch; Cation transport regulator like protein 1; Cation transport regulator-like protein 1; ChaC; ChaC cation transport regulator homolog 1; ChaC cation transport regulator like 1; chac1; CHAC1_HUMAN; Gamma GCT acting on glutathione homolog 1; Gamma-GCG 1; Glutathione-specific gamma-glutamylcyclotransferase 1
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    full length protein
  • 表達區(qū)域:
    1-264
  • 氨基酸序列
    MGGAQLELPS GARPGVCVRR SFRAHAGDQP RRPPGPIPVP GTMKQESAAP NTPPTSQSPT PSAQFPRNDG DPQALWIFGY GSLVWRPDFA YSDSRVGFVR GYSRRFWQGD TFHRGSDKMP GRVVTLLEDH EGCTWGVAYQ VQGEQVSKAL KYLNVREAVL GGYDTKEVTF YPQDAPDQPL KALAYVATPQ NPGYLGPAPE EAIATQILAC RGFSGHNLEY LLRLADFMQL CGPQAQDEHL AAIVDAVGTM LPCFCPTEQA LALV
  • 蛋白標(biāo)簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能:
    Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides. Glutathione depletion is an important factor for apoptosis initiation and execution. Acts as a pro-apoptotic component of the unfolded protein response pathway by mediating the pro-apoptotic effects of the ATF4-ATF3-DDIT3/CHOP cascade. Negative regulator of Notch signaling pathway involved in embryonic neurogenesis: acts by inhibiting Notch cleavage by furin, maintaining Notch in an immature inactive form, thereby promoting neurogenesis in embryos.
  • 基因功能參考文獻:
    1. The data revealed that CHAC2 prevented CHAC1-mediated GSH degradation, which suggests that CHAC2 competes with CHAC1 to maintain GSH homeostasis. PMID: 29054545
    2. Temozolomide (TMZ)-mediated gene expression profiles and networks are involved in inducing glioblastoma cell death. Increased CHAC1 and reduced Notch3 levels are both also significantly involved in TMZ-mediated cytotoxicity. The TMZ-regulated CHAC1 pathway inhibits Notch3 activation, resulting in attenuation of Notch3-mediated signaling pathways. PMID: 27986595
    3. Human CHAC1 Protein Degrades Glutathione, and mRNA Induction Is Regulated by the Transcription Factors ATF4 and ATF3 and a Bipartite ATF/CRE Regulatory Element. PMID: 25931127
    4. Botch regulates Notch signaling through deglycination and identify a posttranslational modification of Notch that plays an important role in neurogenesis. PMID: 24767995
    5. nisin exerts these effects on HNSCC, in part, through CHAC1, a proapoptotic cation transport regulator, and through a concomitant CHAC1-independent influx of extracellular calcium PMID: 23342279
    6. High CHAC1 mRNA expression could be an independent indicator for elevated risk of cancer recurrence in breast and ovarian cancer PMID: 22108517

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm, cytosol. Golgi apparatus, trans-Golgi network.
  • 蛋白家族:
    Gamma-glutamylcyclotransferase family, ChaC subfamily
  • 數(shù)據(jù)庫鏈接:

    HGNC: 28680

    OMIM: 614587

    KEGG: hsa:79094

    STRING: 9606.ENSP00000398105

    UniGene: Hs.155569



主站蜘蛛池模板: 欧美精品久久久久久久自慰| 成人免费的视频| 中文字幕欧美人妻精品一区| 麻豆tv入口在线看| 久久久久日韩精品免费观看| 中文字幕日本特黄aa毛片| 人妻巨大乳挤奶水hd免费看| 天天躁久久躁日日躁| 久久国产精品老女人| 亚洲人成图片小说网站| 欧美性色19p| 日本人妻丰满熟妇久久久久久 | 奶真大水真多小荡货av| 亚洲人成电影免费观看在线看| 8x国产精品视频| 精品熟女少妇av免费久久| 欧美日韩精品人妻狠狠躁免费视频 | 一区二区视频传媒有限公司 | 成人午夜高潮免费视频在线观看| 久久国产色欲av38| 免费国产线观看免费观看| 亚洲情综合五月天| 色翁荡熄又大又硬又粗又视频图片 | 在线精品自偷自拍无码| 亚洲人成无码网站久久99热国产| 西西人体44www大胆无码| 国模无码人体一区二区| 国产精品天干天干在线综合| 噜噜久久噜噜久久鬼88| 18禁裸体动漫美女无遮挡网站| 成人综合网站| 国产一卡三卡四卡无卡精品| 中文av伊人av无码av狼人| 国产精品va在线播放| 777久久精品一区二区三区无码| 亚洲国产精品久久亚洲精品| 国产 高清 无码 在线播放| 久久国产精品人妻丝袜| 嫩草伊人久久精品少妇av| 国内少妇毛片视频| 精产国品一二三产区蘑菇视频|