在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Cation transport regulator-like protein 1 (CHAC1)

Recombinant Human Cation transport regulator-like protein 1 (CHAC1)

  • 中文名稱：
    Recombinant Human Cation transport regulator-like protein 1(CHAC1)
  • 貨號：
    CSB-YP883606HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human Cation transport regulator-like protein 1(CHAC1)
  • 貨號：
    CSB-EP883606HU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human Cation transport regulator-like protein 1(CHAC1)
  • 貨號：
    CSB-EP883606HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human Cation transport regulator-like protein 1(CHAC1)
  • 貨號：
    CSB-BP883606HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human Cation transport regulator-like protein 1(CHAC1)
  • 貨號：
    CSB-MP883606HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    CHAC1
  • Uniprot No.：
  • 別名：
    Blocks Notch protein; Botch; Cation transport regulator like protein 1; Cation transport regulator-like protein 1; ChaC; ChaC cation transport regulator homolog 1; ChaC cation transport regulator like 1; chac1; CHAC1_HUMAN; Gamma GCT acting on glutathione homolog 1; Gamma-GCG 1; Glutathione-specific gamma-glutamylcyclotransferase 1
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    full length protein
  • 表達區(qū)域：
    1-264
  • 氨基酸序列
    MGGAQLELPS GARPGVCVRR SFRAHAGDQP RRPPGPIPVP GTMKQESAAP NTPPTSQSPT PSAQFPRNDG DPQALWIFGY GSLVWRPDFA YSDSRVGFVR GYSRRFWQGD TFHRGSDKMP GRVVTLLEDH EGCTWGVAYQ VQGEQVSKAL KYLNVREAVL GGYDTKEVTF YPQDAPDQPL KALAYVATPQ NPGYLGPAPE EAIATQILAC RGFSGHNLEY LLRLADFMQL CGPQAQDEHL AAIVDAVGTM LPCFCPTEQA LALV
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides. Glutathione depletion is an important factor for apoptosis initiation and execution. Acts as a pro-apoptotic component of the unfolded protein response pathway by mediating the pro-apoptotic effects of the ATF4-ATF3-DDIT3/CHOP cascade. Negative regulator of Notch signaling pathway involved in embryonic neurogenesis: acts by inhibiting Notch cleavage by furin, maintaining Notch in an immature inactive form, thereby promoting neurogenesis in embryos.
  • 基因功能參考文獻：
    1. The data revealed that CHAC2 prevented CHAC1-mediated GSH degradation, which suggests that CHAC2 competes with CHAC1 to maintain GSH homeostasis. PMID: 29054545
    2. Temozolomide (TMZ)-mediated gene expression profiles and networks are involved in inducing glioblastoma cell death. Increased CHAC1 and reduced Notch3 levels are both also significantly involved in TMZ-mediated cytotoxicity. The TMZ-regulated CHAC1 pathway inhibits Notch3 activation, resulting in attenuation of Notch3-mediated signaling pathways. PMID: 27986595
    3. Human CHAC1 Protein Degrades Glutathione, and mRNA Induction Is Regulated by the Transcription Factors ATF4 and ATF3 and a Bipartite ATF/CRE Regulatory Element. PMID: 25931127
    4. Botch regulates Notch signaling through deglycination and identify a posttranslational modification of Notch that plays an important role in neurogenesis. PMID: 24767995
    5. nisin exerts these effects on HNSCC, in part, through CHAC1, a proapoptotic cation transport regulator, and through a concomitant CHAC1-independent influx of extracellular calcium PMID: 23342279
    6. High CHAC1 mRNA expression could be an independent indicator for elevated risk of cancer recurrence in breast and ovarian cancer PMID: 22108517

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm, cytosol. Golgi apparatus, trans-Golgi network.
  • 蛋白家族：
    Gamma-glutamylcyclotransferase family, ChaC subfamily
  • 數(shù)據(jù)庫鏈接：

    HGNC: 28680

    OMIM: 614587

    KEGG: hsa:79094

    STRING: 9606.ENSP00000398105

    UniGene: Hs.155569



主站蜘蛛池模板： 永久免费看啪啪网址入口| 午夜视频在线在免费| 18禁精品久久久国产精品久久久| 欧美肥老太交性506070| 五十路熟妇高熟无码视频 | 欧洲日韩亚洲无线在码| 久99视频精品免费观看福利| 97热久久免费频精品99| 男女无遮挡xx00动态图120秒| 在线看片人成视频免费无遮挡| 久久久久国产一区二区三区| 亚洲精品无码专区在线观看| 人人澡人人澡人人看添| 欧美日韩精品一区二区三区高清视频| 色综亚洲国产vv在线观看| 色综合久久久久久久久久| 亚洲gv天堂gv无码男同| 久久久噜噜噜久久熟女| 日韩精品成人av在线观看| 日本猛少妇色xxxxx猛叫| 亚洲精品～无码抽插| 亚洲国产精品无码久久久动漫| 国产精品一区二区av交换| 久久亚洲精品成人av| 国产成人无码精品久久久性色| 电影久久久久久| 国产av一区二区精品久久| 久久久久久久久无码精品亚洲日韩| 欧美成人精品手机在线| 国产熟妇午夜精品aaa| 日本乱人伦aⅴ精品| 日韩a∨精品日韩在线观看| 精品久久久久久无码中文字幕一区| 少女高清影视在线观看动漫| 少妇激情作爱视频| 在线成人精品国产区免费| 99精品国产在热久久无码| 香蕉蕉亚亚洲aav综合| 男人狂躁进女人下面免费视频| 人妻少妇中文字幕乱码| 日本特黄特黄刺激大片|