在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

CHAC1 Antibody

  • 中文名稱:
    CHAC1兔多克隆抗體
  • 貨號:
    CSB-PA634200
  • 規格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA634200(CHAC1 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    CHAC1
  • 別名:
    Blocks Notch protein antibody; Botch antibody; Cation transport regulator like protein 1 antibody; Cation transport regulator-like protein 1 antibody; ChaC antibody; ChaC cation transport regulator homolog 1 antibody; ChaC cation transport regulator like 1 antibody; chac1 antibody; CHAC1_HUMAN antibody; Gamma GCT acting on glutathione homolog 1 antibody; Gamma-GCG 1 antibody; Glutathione-specific gamma-glutamylcyclotransferase 1 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Fusion protein of Human CHAC1
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    IHC 1:25-1:100
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides. Glutathione depletion is an important factor for apoptosis initiation and execution. Acts as a pro-apoptotic component of the unfolded protein response pathway by mediating the pro-apoptotic effects of the ATF4-ATF3-DDIT3/CHOP cascade. Negative regulator of Notch signaling pathway involved in embryonic neurogenesis: acts by inhibiting Notch cleavage by furin, maintaining Notch in an immature inactive form, thereby promoting neurogenesis in embryos.
  • 基因功能參考文獻:
    1. The data revealed that CHAC2 prevented CHAC1-mediated GSH degradation, which suggests that CHAC2 competes with CHAC1 to maintain GSH homeostasis. PMID: 29054545
    2. Temozolomide (TMZ)-mediated gene expression profiles and networks are involved in inducing glioblastoma cell death. Increased CHAC1 and reduced Notch3 levels are both also significantly involved in TMZ-mediated cytotoxicity. The TMZ-regulated CHAC1 pathway inhibits Notch3 activation, resulting in attenuation of Notch3-mediated signaling pathways. PMID: 27986595
    3. Human CHAC1 Protein Degrades Glutathione, and mRNA Induction Is Regulated by the Transcription Factors ATF4 and ATF3 and a Bipartite ATF/CRE Regulatory Element. PMID: 25931127
    4. Botch regulates Notch signaling through deglycination and identify a posttranslational modification of Notch that plays an important role in neurogenesis. PMID: 24767995
    5. nisin exerts these effects on HNSCC, in part, through CHAC1, a proapoptotic cation transport regulator, and through a concomitant CHAC1-independent influx of extracellular calcium PMID: 23342279
    6. High CHAC1 mRNA expression could be an independent indicator for elevated risk of cancer recurrence in breast and ovarian cancer PMID: 22108517

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm, cytosol. Golgi apparatus, trans-Golgi network.
  • 蛋白家族:
    Gamma-glutamylcyclotransferase family, ChaC subfamily
  • 數據庫鏈接:

    HGNC: 28680

    OMIM: 614587

    KEGG: hsa:79094

    STRING: 9606.ENSP00000398105

    UniGene: Hs.155569



主站蜘蛛池模板: 丰满人妻熟妇乱又伦精品软件| 亚洲国产欧美国产综合一区| 亚洲精品亚洲人成在线| 国产精品爽爽久久久久久竹菊| 风韵人妻丰满熟妇老熟女| √天堂资源地址中文在线| 大肉大捧一进一出好爽mba| 欧美高清freexxxx性| 国产激情大臿免费视频| 蜜臀精品国产高清在线观看| 色777狠狠狠综合| 国产第一页浮力影院草草| 久久久久免费看黄a片app| 欧美s码亚洲码精品m码| 黑人粗长大战亚洲女| 日韩精品一区二区三区vr| 日日摸日日碰夜夜爽无码| 久久精品手机观看| 成人免费无码大片a毛片| 少妇私密会所按摩到高潮呻吟| 五月天激情电影| 人妻avav中文系列久久| 国产综合一区二区三区黄页秋霞| 特黄三级又爽又粗又大| 麻豆精品久久久久久久99蜜桃| 十八禁啪啪无遮挡网站| 久久久久国色av∨免费看| 99久re热视频这里只有精品6| 草的我好爽视频| 全部孕妇毛片丰满孕妇孕交| 日本簧片在线观看| 精品国产av最大网站| 亚洲爆乳aaa无码专区| 欧美丰满熟妇bbb久久久| 欧美一区二区三区激情| 国产69囗曝吞精在线视频| 国产sm精品调教视频网址| 丰满的少妇愉情hd高清果冻传媒| 无套内谢孕妇毛片免费看| 亚洲精品久久久久久中文字幕| 国产农村乱人伦精品视频|