在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Cartilage intermediate layer protein 1 (CILP), partial

In Stock
  • 中文名稱:
    Recombinant Human Cartilage intermediate layer protein 1(CILP),partial
  • 品名簡稱:
    Recombinant Human CILP protein, partial
  • 貨號:
    CSB-BP005437HUb1
  • 說明書:
  • 規(guī)格:
    ¥3168
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產(chǎn)品詳情

  • 純度:
    Greater than 85% as determined by SDS-PAGE.
  • 基因名:
    CILP
  • Uniprot No.:
  • 別名:
    Cartilage intermediate layer protein 1; Cartilage intermediate layer protein 1 C1; Cartilage intermediate layer protein 1 C2; cartilage intermediate layer protein; cartilage intermediate layer protein; nucleotide pyrophosphohydrolase; Cartilage intermediate-layer protein; CILP 1; CILP; CILP-1; CILP1_HUMAN; HGNC:1980; HsT18872
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Partial
  • 來源:
    Baculovirus
  • 分子量:
    55.7 kDa
  • 表達區(qū)域:
    725-1184aa
  • 氨基酸序列
    EDRTFLVGNLEIRERRLFNLDVPESRRCFVKVRAYRSERFLPSEQIQGVVISVINLEPRTGFLSNPRAWGRFDSVITGPNGACVPAFCDDQSPDAYSAYVLASLAGEELQAVESSPKFNPNAIGVPQPYLNKLNYRRTDHEDPRVKKTAFQISMAKPRPNSAEESNGPIYAFENLRACEEAPPSAAHFRFYQIEGDRYDYNTVPFNEDDPMSWTEDYLAWWPKPMEFRACYIKVKIVGPLEVNVRSRNMGGTHRQTVGKLYGIRDVRSTRDRDQPNVSAACLEFKCSGMLYDQDRVDRTLVKVIPQGSCRRASVNPMLHEYLVNHLPLAVNNDTSEYTMLAPLDPLGHNYGIYTVTDQDPRTAKEIALGRCFDGTSDGSSRIMKSNVGVALTFNCVERQVGRQSAFQYLQSTPAQSPAAGTVQGRVPSRRQQRASRGGQRQGGVVASLRFPRVAQQPLIN
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 10xHis-tagged and C-terminal Myc-tagged
  • 產(chǎn)品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Tris-based buffer,50% glycerol
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    3-7 business days
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能:
    Probably plays a role in cartilage scaffolding. May act by antagonizing TGF-beta1 (TGFB1) and IGF1 functions. Has the ability to suppress IGF1-induced proliferation and sulfated proteoglycan synthesis, and inhibits ligand-induced IGF1R autophosphorylation. May inhibit TGFB1-mediated induction of cartilage matrix genes via its interaction with TGFB1. Overexpression may lead to impair chondrocyte growth and matrix repair and indirectly promote inorganic pyrophosphate (PPi) supersaturation in aging and osteoarthritis cartilage.
  • 基因功能參考文獻:
    1. CILP rs2073711 TT is associated with increased risk of symmetrical hand osteoarthritis particularly in individuals with low variation in work tasks. PMID: 29233086
    2. Meta-analysis. Our results confirm the positive association between CILP and intervertebral disc degeneration, providing novel clues for clarifying the role of CILP in the development of IVD. PMID: 27359356
    3. CILP is involved in the etiology of intervertebral disc degeneration among young adults. PMID: 22107760
    4. The researchers found that the single nucleotide polymorphism (1184T/C) of the CILP gene is associated an increased risk of lumbar disc degeneration in male athletes. PMID: 20724643
    5. CILP regulates TGF-beta signaling and that this regulation has a crucial role in the etiology and pathogenesis of LDD. PMID: 15864306
    6. These observations, together with the finding that CILP protein binds and inhibits TGF-beta1, suggest that CILP and TGF-beta1 may form a functional feedback loop that controls chondrocyte metabolism. PMID: 16413503
    7. SNP analysis suggested that the CILP gene is not a major risk factor for symptoms of lumbar disc disease in Finnish or Chinese populations. PMID: 17220213
    8. the CILP gene 1184T/C polymorphism is a significant risk factor for lumbar disc degeneration occurrence in Japanese collegiate judo athletes PMID: 19569011

    顯示更多

    收起更多

  • 相關(guān)疾病:
    Intervertebral disc disease (IDD)
  • 亞細胞定位:
    Secreted, extracellular space, extracellular matrix.
  • 組織特異性:
    Specifically expressed in cartilage. Localizes in the intermediates layer of articular cartilage but neither in the superficial nor in the deepest regions. Specifically and highly expressed in intervertebral disk tissue. Expression increases with aging in
  • 數(shù)據(jù)庫鏈接:

    HGNC: 1980

    OMIM: 603489

    KEGG: hsa:8483

    STRING: 9606.ENSP00000261883

    UniGene: Hs.442180



主站蜘蛛池模板: 蜜桃av亚洲精品一区二区| 人妻一本久道久久综合久久鬼色| 中文有码亚洲制服av片| 午夜三级a三级三点窝| 亚洲一区二区三区高清av| 青草内射中出高潮| 麻花传媒剧国产mv高清播放| 亚洲乱码日产精品bd在| 国产乱人伦av在线麻豆a| 亚洲第一无码av无码专区| 无码爆乳护士让我爽| 日本熟妇大屁股人妻| 亚洲性无码av在线欣赏网| 久久久无码精品午夜| 久久人妻国产精品| 亚洲欧洲日产国码无码网站| 精品无码国产自产拍在线观看| 国产精品成人99一区无码 | 亚洲精品一区中文字幕乱码| 久久综合伊人九色综合| 久久精品国产欧美日韩99热 | 久久人妻少妇嫩草av无码专区| 艳妇乳肉豪妇荡乳| 国产69精品久久久久乱码免费| 蜜臀色欲av在线播放国产日韩| 秋霞午夜一区二区三区黄瓜视频| 日本乱偷人妻中文字幕| 国产成人av在线影院| 国产gv在线观看受被做哭| 国产偷窥熟精品视频| 亚洲中文精品久久久久久| 手机在线看永久av片免费 | 在线观看国产午夜福利片| 麻豆国产精成人品观看免费| 日韩精品成人一区二区三区| 国产精品爽爽久久久久久| 放荡的美妇在线播放| 麻豆果冻精东九一传媒mv| 久久精品九九亚洲精品天堂| 国产精品日韩欧美一区二区三区| 国内精品国产三级国产av|