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  4. Recombinant Human Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 (CTDSP1)

Recombinant Human Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 (CTDSP1)

  • 中文名稱：
    Recombinant Human Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1(CTDSP1)
  • 貨號：
    CSB-YP880927HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1(CTDSP1)
  • 貨號：
    CSB-EP880927HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1(CTDSP1)
  • 貨號：
    CSB-EP880927HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1(CTDSP1)
  • 貨號：
    CSB-BP880927HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1(CTDSP1)
  • 貨號：
    CSB-MP880927HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    CTDSP1
  • Uniprot No.：
  • 別名：
    Carboxy terminal domain RNA polymerase II polypeptide A small phosphatase 1; Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1; CTD (carboxy terminal domain RNA polymerase II polypeptide A) small phosphatase 1; CTD small phosphatase 1; CTDS1_HUMAN; CTDSP1; NIF3; NLI IF ; NLI interacting factor 3; NLI-IF; NLI-interacting factor 3; NLIIF ; Nuclear LIM interactor interacting factor 3; Nuclear LIM interactor-interacting factor 3; SCP1; Small C-terminal domain phosphatase 1; Small CTD phosphatase 1
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    full length protein
  • 表達區域：
    1-261
  • 氨基酸序列
    MDSSAVITQI SKEEARGPLR GKGDQKSAAS QKPRSRGILH SLFCCVCRDD GEALPAHSGA PLLVEENGAI PKQTPVQYLL PEAKAQDSDK ICVVIDLDET LVHSSFKPVN NADFIIPVEI DGVVHQVYVL KRPHVDEFLQ RMGELFECVL FTASLAKYAD PVADLLDKWG AFRARLFRES CVFHRGNYVK DLSRLGRDLR RVLILDNSPA SYVFHPDNAV PVASWFDNMS DTELHDLLPF FEQLSRVDDV YSVLRQPRPG S
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells.
  • 基因功能參考文獻：
    1. SCP1 is the phosphatase that counterregulates the MAPK-mediated phosphorylation of Ser(68)-Twist1. PMID: 26975371
    2. SCP1 regulates c-Myc stability and functions through dephosphorylating c-Myc Serine-62. PMID: 25893300
    3. hSCP1 may be an beta-O-linked N-acetylglucosamine modified protein in vivo. PMID: 25081999
    4. CTDSP1 activity stabilizes REST in stem cells and ERK-dependent phosphorylation combined with Pin1 activity promotes REST degradation in neural progenitors. PMID: 25197063
    5. SCP1 phosphatase substrate specificity: CdcA3 could be an enzymatic substrate for SCP1. PMID: 24769477
    6. Captured the phosphoryl-aspartate intermediate in the crystal structure of a Scp1D206A mutant soaked with para-nitrophenyl phosphate (pNPP), providing strong evidence for the proposed mechanism. PMID: 20222012
    7. Polymorphisms vary significantly between races; Not associated with TB susceptibility in Caucasians. PMID: 11950066
    8. SCP1 may play a role in the regulation of gene expression, possibly by controlling the transition from initiation/capping to processive transcript elongation PMID: 12721286
    9. results show that REST/NRSF recruits SCPs to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells PMID: 15681389
    10. SCP1 acts as a phosphatase for regulatory phosphorylations in the linker region of Smad1 and Smad2. PMID: 17085434

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  • 亞細胞定位：
    Nucleus. Note=Colocalizes with RNA polymerase II.
  • 組織特異性：
    Expression is restricted to non-neuronal tissues. Highest expression in skeletal muscle, spleen, lung and placenta.
  • 數據庫鏈接：

    HGNC: 21614

    OMIM: 605323

    KEGG: hsa:58190

    STRING: 9606.ENSP00000273062

    UniGene: Hs.444468



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