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  4. Recombinant Human CXADR-like membrane protein (CLMP), partial

Recombinant Human CXADR-like membrane protein (CLMP), partial

  • 中文名稱：
    Recombinant Human CXADR-like membrane protein(CLMP),partial
  • 貨號：
    CSB-YP862026HU
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human CXADR-like membrane protein(CLMP),partial
  • 貨號：
    CSB-EP862026HU
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human CXADR-like membrane protein(CLMP),partial
  • 貨號：
    CSB-EP862026HU-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human CXADR-like membrane protein(CLMP),partial
  • 貨號：
    CSB-BP862026HU
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human CXADR-like membrane protein(CLMP),partial
  • 貨號：
    CSB-MP862026HU
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    CLMP
  • Uniprot No.：
  • 別名：
    CLMP; ACAM; ASAM; UNQ318/PRO363CXADR-like membrane protein; Adipocyte adhesion molecule; Coxsackie- and adenovirus receptor-like membrane protein; CAR-like membrane protein
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    May be involved in the cell-cell adhesion. May play a role in adipocyte differentiation and development of obesity. Is required for normal small intestine development.
  • 基因功能參考文獻：
    1. We describe a newborn presenting CSBS intestinal malrotation and chronic intestinal pseudo-obstruction syndrome (CIPS), compound heterozygous for two previously unreported heterozygous mutations in Coxsackie and adenovirus receptor-like membrane protein (CLMP) gene. We identified two heterozygous mutations in CLMP, one in intron 1 (c.28+1G>C) from the father, the other on exon 4 (c502C>T, p.R168X) from the mother. PMID: 27720179
    2. Inhibition of CFTR or histone deacetylase (HDAC) enhanced CAR expression while CFTR overexpression or restoration of the diminished HDAC activity in cystic fibrosis cells reduced CAR expression. PMID: 27527752
    3. Novel inherited variants in CLMP were identified in three congenital short bowel syndrome patients derived from two unrelated families. PMID: 27352967
    4. The key processes involved in intestinal epithelial development appear to be unaffected by wild type-CLMP or mutant-CLMP. PMID: 23460781
    5. Coxsackievirus and adenovirus receptor gene expression is induced in esophageal cancer cells by the HDAC inhibitor trichostatin A. PMID: 22992863
    6. The PDZ1 and PDZ3 domains of MAGI-1 regulate the eight-exon isoform of the CXADR-like membrane protein. PMID: 22718816
    7. Loss-of-function mutations in CLMP cause congenital short bowel syndrome in human beings, likely by interfering with tight-junction formation, which disrupts intestinal development. PMID: 22155368
    8. CLMP is a novel cell-cell adhesion molecule and a new component of epithelial tight junctions. PMID: 14573622
    9. We identified ACAM (adipocyte adhesion molecule), a novel homologue of the CTX (cortical thymocyte marker in Xenopus) gene family, which may be the critical adhesion molecule in adipocyte differentiation and development of obesity. PMID: 15563274
    10. ASAM, IGSF11, CXADR and ESAM are type I transmembrane proteins and members of the same IGSF superfamily. PMID: 12851705

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  • 相關疾病：
    Congenital short bowel syndrome (CSBS)
  • 亞細胞定位：
    Cell junction, tight junction. Cell membrane; Single-pass type I membrane protein.
  • 組織特異性：
    Predominantly expressed in epithelial cells within different tissues and in the white adipose tissue. Expressed at high levels in small intestine and placenta, at intermediate levels in the heart, skeletal muscle, colon, spleen, kidney and lung and at low
  • 數據庫鏈接：

    HGNC: 24039

    OMIM: 611693

    KEGG: hsa:79827

    STRING: 9606.ENSP00000405577

    UniGene: Hs.591949



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