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  4. Recombinant Human CUB and zona pellucida-like domain-containing protein 1 (CUZD1), partial

Recombinant Human CUB and zona pellucida-like domain-containing protein 1 (CUZD1), partial

  • 中文名稱：
    Recombinant Human CUB and zona pellucida-like domain-containing protein 1(CUZD1),partial
  • 貨號：
    CSB-YP774806HU
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human CUB and zona pellucida-like domain-containing protein 1(CUZD1),partial
  • 貨號：
    CSB-EP774806HU
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human CUB and zona pellucida-like domain-containing protein 1(CUZD1),partial
  • 貨號：
    CSB-EP774806HU-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human CUB and zona pellucida-like domain-containing protein 1(CUZD1),partial
  • 貨號：
    CSB-BP774806HU
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human CUB and zona pellucida-like domain-containing protein 1(CUZD1),partial
  • 貨號：
    CSB-MP774806HU
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    CUZD1
  • Uniprot No.：
  • 別名：
    CUB and zona pellucida-like domain-containing protein 1; CUB and ZP domain-containing protein 1; CUZD1; CUZD1_HUMAN; Transmembrane protein UO-44
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Localized to zymogen granules, where it functions in trypsinogen activation. May indirectly regulate cell motility, cell-cell and cell/extracellular matrix interactions.
  • 基因功能參考文獻：
    1. Data suggest that overexpression of CUZD1, regulator of growth factor signaling pathways controlled by PRLR and STAT5, promotes tumorigenesis in mammary epithelial cells. (CUZD1 = CUB and zona pellucida-like domain-containing protein-1; PRLR = prolactin receptor; STAT5 = signal transducer and activator of transcription-5) PMID: 29321207
    2. This study describes the development of tools targeting CUZD1 protein, its tissue expression pattern and levels in several biological fluids. These new tools will facilitate future investigations aiming to delineate the role of CUZD1 in physiology and pathobiology. PMID: 28746862
    3. Totals of 12.4% and 20.8% of Crohn's disease patients were positive for IgA/IgG type of anti-GP2 and anti-CUZD1, respectively. Positivity for anti-pancreatic autoantibodies predicted a faster progression towards complicated disease course. PMID: 25968583
    4. CUZD1 appears to be one of the relatively few biomarkers that serve as both cancer biomarker and autoantigen of autoantibodies in an autoimmune disease unrelated to cancerous organs. (Review) PMID: 23710207
    5. CUZD1 appears to be a highly promising novel serum biomarker for ovarian cancer diagnosis. PMID: 22985796
    6. human UO-44 gene expression may prove to be valuable pretreatment targets for antitumor therapy PMID: 16862170

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  • 亞細胞定位：
    Zymogen granule membrane; Single-pass type I membrane protein.
  • 組織特異性：
    Detected in pancreas and epithelium of ovary. Expressed at higher levels in ovarian tumors than in normal tissue.
  • 數據庫鏈接：

    HGNC: 17937

    OMIM: 616644

    KEGG: hsa:50624

    UniGene: Hs.647182



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