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  4. Recombinant Human CST complex subunit CTC1 (CTC1), partial

Recombinant Human CST complex subunit CTC1 (CTC1), partial

  • 中文名稱：
    Recombinant Human CST complex subunit CTC1(CTC1) ,partial
  • 貨號：
    CSB-YP648341HU
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human CST complex subunit CTC1(CTC1) ,partial
  • 貨號：
    CSB-EP648341HU
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human CST complex subunit CTC1(CTC1) ,partial
  • 貨號：
    CSB-EP648341HU-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human CST complex subunit CTC1(CTC1) ,partial
  • 貨號：
    CSB-BP648341HU
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human CST complex subunit CTC1(CTC1) ,partial
  • 貨號：
    CSB-MP648341HU
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    CTC1
  • Uniprot No.：
  • 別名：
    CTC1; C17orf68; Conserved telomere maintenance component 1; CST complex subunit CTC1; CTC1; CTC1_HUMAN; HBV DNAPTP1-transactivated protein B
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. The CST complex inhibits telomerase and is involved in telomere length homeostasis; it is proposed to bind to newly telomerase-synthesized 3' overhangs and to terminate telomerase action implicating the association with the ACD:POT1 complex thus interfering with its telomerase stimulation activity. The CST complex is also proposed to be involved in fill-in synthesis of the telomeric C-strand probably implicating recruitment and activation of DNA polymerase alpha. The CST complex facilitates recovery from many forms of exogenous DNA damage; seems to be involved in the re-initiation of DNA replication at repaired forks and/or dormant origins. Involved in telomere maintenance. Involved in genome stability. May be in involved in telomeric C-strand fill-in during late S/G2 phase.
  • 基因功能參考文獻：
    1. HBV DNAPTP1 downregulated the expression of SWI5 and CTC1 at translation level. PMID: 27265469
    2. Coats plus syndrome also known as cerebroretinal microangiopathy with calcifications and cysts, is an autosomal recessive pleomorphic disorder caused by the CTS telomere maintenance complex component 1 gene. PMID: 25906927
    3. CTC1 gene screening confirmed the diagnosis of cerebro-retinal microangiopathy with calcifications and cysts with the identification of heterozygous deleterious mutations PMID: 25843205
    4. an Indian family links Coats plus syndrome and dextrocardia with a homozygous novel CTC1 and a rare HES7 variation PMID: 25928698
    5. The mammalian CST (CTC1-STN1-TEN1) complex is directly involved at several stages of telomere end formation and CST seems to play critical roles in coordinating telomerase elongation and fill-in synthesis to complete telomere replication. PMID: 23851344
    6. CTC1 mutations promote telomere dysfunction by decreasing the stability of STN1 to reduce its ability to interact with DNA Polalpha, thus highlighting a previously unknown mechanism to induce telomere dysfunction. PMID: 23869908
    7. identify CTC1 disease mutations that disrupt CST complex formation, the physical interaction with DNA polymerase alpha-primase (polalpha-primase), telomeric ssDNA binding in vitro, accumulation in the nucleus, and/or telomere association in vivo PMID: 24115768
    8. Genome-wide meta-analysis points to CTC1 and ZNF676 as genes regulating telomere homeostasis in humans. PMID: 23001564
    9. CTC1 Mutations are associated with dyskeratosis congenita. PMID: 22532422
    10. Observed four recessively inherited compound heterozygous mutations in CTC1, which encodes the CTS telomere maintenance complex component 1. PMID: 22387016
    11. Mutations in CTC1, encoding conserved telomere maintenance component 1, cause Coats plus. PMID: 22267198
    12. CTC1 participates in telomere maintenance in diverse species and that a CST-like complex is required for telomere integrity in multicellular organisms. PMID: 19854131

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  • 相關疾病：
    Cerebroretinal microangiopathy with calcifications and cysts 1 (CRMCC1)
  • 亞細胞定位：
    Nucleus. Chromosome, telomere.
  • 蛋白家族：
    CTC1 family
  • 數據庫鏈接：

    HGNC: 26169

    OMIM: 612199

    KEGG: hsa:80169

    STRING: 9606.ENSP00000313759

    UniGene: Hs.156055



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