在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase (ST8SIA4)

  • 中文名稱:
    人ST8SIA4重組蛋白
  • 貨號:
    CSB-EP821630HU
  • 規格:
    ¥1344
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產品詳情

  • 純度:
    Greater than 90% as determined by SDS-PAGE.
  • 基因名:
    ST8SIA4
  • Uniprot No.:
  • 別名:
    ST8SIA4; PST; PST1; SIAT8D; CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase; EC 2.4.99.-; Alpha-2,8-sialyltransferase 8D; Polysialyltransferase-1; Sialyltransferase 8D; SIAT8-D; Sialyltransferase St8Sia IV; ST8SiaIV
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Full Length of Isoform 2
  • 來源:
    E.coli
  • 分子量:
    32.8kDa
  • 表達區域:
    21-168aa
  • 氨基酸序列
    KTKEIARTEEHQETQLIGDGELSLSRSLVNSSDKIIRKAGSSIFQHNVEGWKINSSLVLEIRKNILRFLDAERDVSVVKSSFKPGDVIHYVLDRRRTLNISHDLHSLLPEVSPMKNRRFKTCAVVGNSGILLDSECGKEIDSHNFVIR
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 6xHis-SUMO-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
    Note: If you have any special requirement for the glycerol content, please remark when you place the order.
    If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Catalyzes the polycondensation of alpha-2,8-linked sialic acid required for the synthesis of polysialic acid (PSA), which is present on the embryonic neural cell adhesion molecule (N-CAM), necessary for plasticity of neural cells.
  • 基因功能參考文獻:
    1. Different properties of polysialic acids synthesized by the polysialyltransferases ST8SIA2 and ST8SIA4 have been described. PMID: 28810663
    2. our results demonstrate that miR-146a and miR-146b promote proliferation, migration and invasion of FTC via inhibition of ST8SIA4. PMID: 28427206
    3. Data show that miR-181c was inversely correlated with the levels of ST8SIA4 expression in chronic myelocytic leukemia (CML) cell lines and samples. PMID: 27527856
    4. This is the first report to demonstrate a role for a glycosyltransferase in human pluripotent stem cell lineage specification. PMID: 27074314
    5. changes in the glycosylation patterns and sialylation levels may be useful markers of the progression of breast cancer, as well as miR-26a/26b may be widely involved in the regulation of sialylation machinery by targeting ST8SIA4. PMID: 28032858
    6. The polybasic region of the polysialyltransferase ST8Sia-IV binds directly to NCAM. PMID: 28233978
    7. Sequence Requirements for Neuropilin-2 Recognition by ST8SiaIV and Polysialylation of Its O-Glycans. PMID: 26884342
    8. ST8SIA4 gene is involved in the development of multidrug resistance via PI3K/Akt pathway in chronic myeloid leukemia. PMID: 25855199
    9. this study indicated that sialylation involved in the development of MDR of AML cells probably through ST3GAL5 or ST8SIA4 regulating the activity of PI3K/Akt signaling and the expression of P-gp and MRP1. PMID: 24531716
    10. ST8SiaIV synthesized polySia selectively on a NRP2 glycoform that was characterized by the presence of sialylated core 1 and core 2 O-glycans. PMID: 23801331
    11. The ST8SiaIV/PST polybasic region plays a critical role in substrate recognition. PMID: 22184126
    12. polysialylated NCAM persistence, up-regulated polysialyltransferase-1 mRNA and previously uncovered defective myelin-associated glycoprotein may be early pathogenetic events in adult-onset autosomal-dominant leukodystrophy PMID: 19725832
    13. SIAT8D has a role in neural development and sialic acid synthesis on NCAM PMID: 12138100
    14. Pancreatitis risk was highest in individuals with abnormalities in pancreatic duct(CFTR) and acini (PST1) indicating that PST1 is a modifier gene for CFTR-related idiopathic chronic pancreatitis. PMID: 12227654
    15. The upregulation of ST8SIA4 and the donwregulation of ST8SIA2 by valproic acid in HUVEC and tumor cell lines are reported. PMID: 15710344
    16. polysialyltransferase ST8Sia IV/PST recognizes specific amino acids in the first fibronectin type III repeat of the neural cell adhesion molecule PMID: 16027151
    17. PSA-NCAM and ST8Sia-II/IV Expression Is Increased in Pancreatic Carcinomas PMID: 18384787
    18. Amino acid substitutions in conserved sequences are critical for the protein-specific polysialylation of NCAM. PMID: 19336400

    顯示更多

    收起更多

  • 亞細胞定位:
    Golgi apparatus membrane; Single-pass type II membrane protein.
  • 蛋白家族:
    Glycosyltransferase 29 family
  • 組織特異性:
    Highly expressed in fetal brain, lung and kidney and in adult heart, spleen and thymus. Present to a lesser extent in adult brain, placenta, lung, large and small intestine and peripheral blood leukocytes.
  • 數據庫鏈接:

    HGNC: 10871

    OMIM: 602547

    KEGG: hsa:7903

    STRING: 9606.ENSP00000231461

    UniGene: Hs.308628



主站蜘蛛池模板: 日日碰狠狠添天天爽超碰97| 国产女人的高潮国语对白| 99久久婷婷国产综合精品青草免费 | 国产三级在线观看完整版| 亚洲自偷自拍另类11p| 无码国产一区二区三区四区| 波多野结衣一区二区三区高清av| 精品国产日韩亚洲一区| 国产日产欧产美韩系列麻豆| 欧美性猛交xxxx乱大交极品| 国产亚洲精品成人aa片| 日本熟妇美熟bbw| 好了av在线第四综合网站| 久久午夜夜伦鲁鲁片免费无码| 亚洲综合久久一本伊一区| 久久/这里只精品99re66| 成人综合网站| 亚洲综合色成在线播放| 无码av高潮喷水无码专区线| 在线麻豆精东9制片厂av影现网| 99久久婷婷国产综合精品电影| 巨大欧美黑人xxxxbbbb| 欧美激性欧美激情在线| 亚洲va天堂va欧美片a在线| 寂寞少妇做spa按摩无码| 狂野欧美激情性xxxx| 一区二区三区国产精华液| 亚洲乱码日产一区三区| 男女性爽大片视频| 久久好在线视频| 美女视频黄又黄又免费| 国产精品高清不卡在线播放| 男人av无码天堂| 国产午夜亚洲精品不卡在线观看| 国产又爽又粗又猛的视频| 色夜码无码av网站| 97se亚洲国产综合自在线| 久久成人影院精品99| 女人爽得直叫免费视频| 性欧美丰满熟妇xxxx性仙踪林| 国产在线观看www污污污|