在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

ST8SIA4 Antibody, FITC conjugated

  • 中文名稱:
    ST8SIA4兔多克隆抗體, FITC偶聯
  • 貨號:
    CSB-PA821630LC01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) ST8SIA4 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    ST8SIA4
  • 別名:
    ST8SIA4 antibody; PST antibody; PST1 antibody; SIAT8D antibody; CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase antibody; EC 2.4.99.- antibody; Alpha-2,8-sialyltransferase 8D antibody; Polysialyltransferase-1 antibody; Sialyltransferase 8D antibody; SIAT8-D antibody; Sialyltransferase St8Sia IV antibody; ST8SiaIV antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase protein (21-168AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Catalyzes the polycondensation of alpha-2,8-linked sialic acid required for the synthesis of polysialic acid (PSA), which is present on the embryonic neural cell adhesion molecule (N-CAM), necessary for plasticity of neural cells.
  • 基因功能參考文獻:
    1. Different properties of polysialic acids synthesized by the polysialyltransferases ST8SIA2 and ST8SIA4 have been described. PMID: 28810663
    2. our results demonstrate that miR-146a and miR-146b promote proliferation, migration and invasion of FTC via inhibition of ST8SIA4. PMID: 28427206
    3. Data show that miR-181c was inversely correlated with the levels of ST8SIA4 expression in chronic myelocytic leukemia (CML) cell lines and samples. PMID: 27527856
    4. This is the first report to demonstrate a role for a glycosyltransferase in human pluripotent stem cell lineage specification. PMID: 27074314
    5. changes in the glycosylation patterns and sialylation levels may be useful markers of the progression of breast cancer, as well as miR-26a/26b may be widely involved in the regulation of sialylation machinery by targeting ST8SIA4. PMID: 28032858
    6. The polybasic region of the polysialyltransferase ST8Sia-IV binds directly to NCAM. PMID: 28233978
    7. Sequence Requirements for Neuropilin-2 Recognition by ST8SiaIV and Polysialylation of Its O-Glycans. PMID: 26884342
    8. ST8SIA4 gene is involved in the development of multidrug resistance via PI3K/Akt pathway in chronic myeloid leukemia. PMID: 25855199
    9. this study indicated that sialylation involved in the development of MDR of AML cells probably through ST3GAL5 or ST8SIA4 regulating the activity of PI3K/Akt signaling and the expression of P-gp and MRP1. PMID: 24531716
    10. ST8SiaIV synthesized polySia selectively on a NRP2 glycoform that was characterized by the presence of sialylated core 1 and core 2 O-glycans. PMID: 23801331
    11. The ST8SiaIV/PST polybasic region plays a critical role in substrate recognition. PMID: 22184126
    12. polysialylated NCAM persistence, up-regulated polysialyltransferase-1 mRNA and previously uncovered defective myelin-associated glycoprotein may be early pathogenetic events in adult-onset autosomal-dominant leukodystrophy PMID: 19725832
    13. SIAT8D has a role in neural development and sialic acid synthesis on NCAM PMID: 12138100
    14. Pancreatitis risk was highest in individuals with abnormalities in pancreatic duct(CFTR) and acini (PST1) indicating that PST1 is a modifier gene for CFTR-related idiopathic chronic pancreatitis. PMID: 12227654
    15. The upregulation of ST8SIA4 and the donwregulation of ST8SIA2 by valproic acid in HUVEC and tumor cell lines are reported. PMID: 15710344
    16. polysialyltransferase ST8Sia IV/PST recognizes specific amino acids in the first fibronectin type III repeat of the neural cell adhesion molecule PMID: 16027151
    17. PSA-NCAM and ST8Sia-II/IV Expression Is Increased in Pancreatic Carcinomas PMID: 18384787
    18. Amino acid substitutions in conserved sequences are critical for the protein-specific polysialylation of NCAM. PMID: 19336400

    顯示更多

    收起更多

  • 亞細胞定位:
    Golgi apparatus membrane; Single-pass type II membrane protein.
  • 蛋白家族:
    Glycosyltransferase 29 family
  • 組織特異性:
    Highly expressed in fetal brain, lung and kidney and in adult heart, spleen and thymus. Present to a lesser extent in adult brain, placenta, lung, large and small intestine and peripheral blood leukocytes.
  • 數據庫鏈接:

    HGNC: 10871

    OMIM: 602547

    KEGG: hsa:7903

    STRING: 9606.ENSP00000231461

    UniGene: Hs.308628



主站蜘蛛池模板: 国产乱子伦精品免费无码专区| 国产成人精品999在线观看| 国产日韩欧美亚欧在线观看| 网禁拗女稀缺资源在线观看| 久久99国产综合精品| 国产av寂寞骚妇| 精品国产综合成人亚洲区| 麻豆日产精品卡2卡3卡4卡5卡| 久久人人做人人妻人人玩精品va| 牛牛视频一区二区三区| 国产亚洲精品aaaaaaa片| 久爱www人成免费网站| 亚洲日本一区二区三区在线| 少妇av一区二区三区无码| 亚洲精品久久久无码av片软件| 日99久9在线 | 免费| 国产裸体美女永久免费无遮挡| 一二三四免费观看在线视频中文版| 国产精品国语对白露脸在线播放 | 中文人妻av大区中文不卡| 亚洲国产精品一区二区成人片国内| 亚洲成av人片不卡无码| 日本成熟老妇乱| 中字幕久久久人妻熟女天美传媒| 狠狠色丁香久久综合| 人人妻人人澡人人爽| 成人国产mv免费视频| 亚洲国产成人精品无码区蜜柚| 亚洲精品一区久久久久| 国产亚洲精品久久久久久无几年桃| 国产精品点击进入在线影院高清| av无码av在线a∨天堂毛片| 风韵多水的老熟妇| 免费无遮挡无码视频网站| 少妇人妻中文字幕hd| 久久久久高潮毛片免费全部播放| 尤物av无码色av无码| 果冻传媒mv免费播放在线观看| 久久性色av亚洲电影| 国产精品www夜色视频| 最新网站亚洲人成无码|