在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human CAD protein (CAD), partial

In Stock
  • 貨號:
    CSB-EP326741HUa0
  • 規(guī)格:
    ¥1344
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產品詳情

  • 純度:
    Greater than 90% as determined by SDS-PAGE.
  • 基因名:
    CAD
  • Uniprot No.:
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Partial
  • 來源:
    E.coli
  • 分子量:
    46.7 kDa
  • 表達區(qū)域:
    1456-1846aa
  • 氨基酸序列
    MTSQKLVRLPGLIDVHVHLREPGGTHKEDFASGTAAALAGGITMVCAMPNTRPPIIDAPALALAQKLAEAGARCDFALFLGASSENAGTLGTVAGSAAGLKLYLNETFSELRLDSVVQWMEHFETWPSHLPIVAHAEQQTVAAVLMVAQLTQRSVHICHVARKEEILLIKAAKARGLPVTCEVAPHHLFLSHDDLERLGPGKGEVRPELGSRQDVEALWENMAVIDCFASDHAPHTLEEKCGSRPPPGFPGLETMLPLLLTAVSEGRLSLDDLLQRLHHNPRRIFHLPPQEDTYVEVDLEHEWTIPSHMPFSKAHWTPFEGQKVKGTVRRVVLRGEVAYIDGQVLVPPGYGQDVRKWPQGAVPQLPPSAPATSEMTTTPERPRRGIPGLPD
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 6xHis-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    3-7 business days
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    This protein is a 'fusion' protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase).
  • 基因功能參考文獻:
    1. CAD dihydroorotase and aspartate transcarbamoylase domains self-assembles into dimers and trimers. PMID: 28552578
    2. Detection of the CAD-ALK gene fusion in urine tr-DNA anticipated radiological confirmation of disease progression. Analysis of plasma ctDNA identified ALK kinase mutations that emerged during treatment with the ALK inhibitor entrectinib PMID: 28368455
    3. Charge neutralization in the active site of the catalytic trimer of aspartate transcarbamoylase promotes diverse structural changes. PMID: 28833948
    4. This study showed that CAD deficiency co-occurrence of anaemia, anisopoikilocytosis, global developmental delay, and seizures. PMID: 28007989
    5. Previous study found three metal ions in huDHOase active site; in the present study, the putative third metal binding site in type II enzymes, such as StDHOase and ScDHOase, was created and identified. PMID: 26446564
    6. Changes in glycosylation in caused by mutations in CAD. PMID: 25678555
    7. These results establish CAD as a downstream effector of Rheb and suggest a possible role of Rheb in regulating de novo pyrimidine nucleotide synthesis PMID: 25422319
    8. Recombinant aspartate carbamoyltransferase domain from the CAD enzyme complex forms homotrimers in solution. PMID: 24316846
    9. The results obtained indicate that mLST8 bridges between CAD and mTOR, and plays a role in the signaling mechanism where CAD is regulated in the mTOR pathway through the association with mLST8 PMID: 23594158
    10. preliminary X-ray diffraction analysis of the dihydroorotase domain of human CAD PMID: 23143245
    11. findings show that in prostate tumor cells, CAD fosters androgen receptor translocation into the nucleus and stimulates its transcriptional activity; in radical prostatectomy specimens, CAD expression was not correlated with proliferation markers, but a higher CAD mRNA level was associated with local tumor extension and cancer relapse PMID: 21982950
    12. the cad gene is regulated by a nonclassical ERalpha/Sp1-mediated pathway. PMID: 12746293
    13. Data show that PRMT5 can be found in association with hSWI/SNF complexes and is involved in regulating the expression of carbamoyl-phosphate synthase-aspartate carbamoyltransferase-dihydroorotase. PMID: 14559996
    14. the nuclear import of CAD appears to promote optimal cell growth PMID: 15890648
    15. cad gene expression is repressed by hypoxia-inducible factor-1alpha, which represents a functional link between hypoxia and cell-cycle arrest. PMID: 16155188
    16. hCPS_DeltaA was not able to fully assume the catalytically competent conformation, with specific activity of CP formation decreased 700-fold. PMID: 18679823

    顯示更多

    收起更多

  • 相關疾病:
    Epileptic encephalopathy, early infantile, 50 (EIEE50)
  • 亞細胞定位:
    Cytoplasm. Nucleus. Note=Cytosolic and unphosphorylated in resting cells, translocates to the nucleus in response to EGF stimulation, nuclear import promotes optimal cell growth.
  • 蛋白家族:
    Metallo-dependent hydrolases superfamily, DHOase family, CAD subfamily
  • 數(shù)據(jù)庫鏈接:

    HGNC: 1424

    OMIM: 114010

    KEGG: hsa:790

    STRING: 9606.ENSP00000264705

    UniGene: Hs.377010



主站蜘蛛池模板: 伊人久久无码中文字幕| 午夜爽爽爽男女免费观看影院| 久久国产乱子伦精品免费女人| 国产一卡2卡3卡4卡精品| 影视av久久久噜噜噜噜噜三级 | 国产专区国产av| 欧美性猛交xxxx黑人| 欧美性色黄大片www喷水| 日本一卡2卡3卡4卡免费精品| 色欲网天天无码av| 在线亚洲人成电影网站色www| 精久国产av一区二区三区孕妇| 亚洲精品v天堂中文字幕| 在线观看成人年视频免费| 亚洲天天做日日做天天欢毛片 | 艳妇乳肉豪妇荡乳av无码福利| 成人伊人亚洲人综合网站| 亚洲精品拍拍央视网出文| 99久久国产综合精品五月天喷水| 丰满熟妇被猛烈进入高清片| 日本免费一区二区三区四区五六区 | 夜夜高潮夜夜爽夜夜爱爱一区| 无码人妻aⅴ一区二区三区| 日本japanese丰满白浆| 亚洲香蕉aⅴ视频在线播放| 久久精品中文字幕第一页| 人人人妻人人澡人人爽欧美一区| 日本精品久久久久中文字幕 | 青青草原精品99久久精品66| 人妻夜夜爽天天爽三区丁香花| 最近免费中文字幕大全免费版视频| 国产av一区二区精品凹凸| 无码乱肉视频免费大全合集| 国产精品偷伦视频免费观看了| 国产内射合集颜射| 国产成人国拍亚洲精品| 亚洲精品鲁一鲁一区二区三区| 综合人妻久久一区二区精品| 国产性猛交普通话对白| 亚洲精品午夜理伦不卡在线观看 | 毛茸茸的中国女bbw|