在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Phospho-CAD (T456) Antibody

  • 中文名稱:
    磷酸化-CAD (T456)兔多克隆抗體
  • 貨號:
    CSB-PA060131
  • 規格:
    ¥1090
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    CAD
  • 別名:
    CAD antibody; CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase antibody; EC 6.3.5.5); Aspartate carbamoyltransferase antibody; EC 2.1.3.2); Dihydroorotase antibody; EC 3.5.2.3)] antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse
  • 免疫原:
    Synthesized peptide derived from Human CAD around the phosphorylation site of T456.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    IHC, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:100-1:300
    ELISA 1:5000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    This protein is a 'fusion' protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase).
  • 基因功能參考文獻:
    1. CAD dihydroorotase and aspartate transcarbamoylase domains self-assembles into dimers and trimers. PMID: 28552578
    2. Detection of the CAD-ALK gene fusion in urine tr-DNA anticipated radiological confirmation of disease progression. Analysis of plasma ctDNA identified ALK kinase mutations that emerged during treatment with the ALK inhibitor entrectinib PMID: 28368455
    3. Charge neutralization in the active site of the catalytic trimer of aspartate transcarbamoylase promotes diverse structural changes. PMID: 28833948
    4. This study showed that CAD deficiency co-occurrence of anaemia, anisopoikilocytosis, global developmental delay, and seizures. PMID: 28007989
    5. Previous study found three metal ions in huDHOase active site; in the present study, the putative third metal binding site in type II enzymes, such as StDHOase and ScDHOase, was created and identified. PMID: 26446564
    6. Changes in glycosylation in caused by mutations in CAD. PMID: 25678555
    7. These results establish CAD as a downstream effector of Rheb and suggest a possible role of Rheb in regulating de novo pyrimidine nucleotide synthesis PMID: 25422319
    8. Recombinant aspartate carbamoyltransferase domain from the CAD enzyme complex forms homotrimers in solution. PMID: 24316846
    9. The results obtained indicate that mLST8 bridges between CAD and mTOR, and plays a role in the signaling mechanism where CAD is regulated in the mTOR pathway through the association with mLST8 PMID: 23594158
    10. preliminary X-ray diffraction analysis of the dihydroorotase domain of human CAD PMID: 23143245
    11. findings show that in prostate tumor cells, CAD fosters androgen receptor translocation into the nucleus and stimulates its transcriptional activity; in radical prostatectomy specimens, CAD expression was not correlated with proliferation markers, but a higher CAD mRNA level was associated with local tumor extension and cancer relapse PMID: 21982950
    12. the cad gene is regulated by a nonclassical ERalpha/Sp1-mediated pathway. PMID: 12746293
    13. Data show that PRMT5 can be found in association with hSWI/SNF complexes and is involved in regulating the expression of carbamoyl-phosphate synthase-aspartate carbamoyltransferase-dihydroorotase. PMID: 14559996
    14. the nuclear import of CAD appears to promote optimal cell growth PMID: 15890648
    15. cad gene expression is repressed by hypoxia-inducible factor-1alpha, which represents a functional link between hypoxia and cell-cycle arrest. PMID: 16155188
    16. hCPS_DeltaA was not able to fully assume the catalytically competent conformation, with specific activity of CP formation decreased 700-fold. PMID: 18679823

    顯示更多

    收起更多

  • 相關疾病:
    Epileptic encephalopathy, early infantile, 50 (EIEE50)
  • 亞細胞定位:
    Cytoplasm. Nucleus. Note=Cytosolic and unphosphorylated in resting cells, translocates to the nucleus in response to EGF stimulation, nuclear import promotes optimal cell growth.
  • 蛋白家族:
    Metallo-dependent hydrolases superfamily, DHOase family, CAD subfamily
  • 數據庫鏈接:

    HGNC: 1424

    OMIM: 114010

    KEGG: hsa:790

    STRING: 9606.ENSP00000264705

    UniGene: Hs.377010



主站蜘蛛池模板: 亚洲熟妇av一区二区三区浪潮| 中国美女牲交视频| 嫩草国产福利视频一区二区| 亚洲六月丁香六月婷婷| 精品无人国产偷自产在线| 久久精品国产色蜜蜜麻豆 | 亚洲色无码播放| 欧美日韩一区二区综合| 少妇无码一区二区三区| 无码午夜成人1000部免费视频| 国产成人92精品午夜福利| 日本免费一本一二区三区| 99国产精品欧美一区二区三区| 国产三级在线观看完整版| 欧美激情一区二区三区在线| 激情五月色综合国产精品| 国产精品内射视频免费| 秋霞午夜鲁丝片午夜精品| 性色香蕉av久久久天天网| 凹凸在线无码免费视频| 丁香五月亚洲综合在线| 在线亚洲视频网站www色| 超碰97人人做人人爱亚洲尤物| 亚洲欧美日产综合在线| 亚洲日韩一区精品射精| 久久欧美与黑人双交男男| 国产美女无遮挡裸色视频| 少妇人妻中文字幕hd| 人妻无码中字在线a| 俺去俺来也在线www色官网| 亚洲中文字幕无码av| 国产成人8x人在线视频软件| 日本乱码一区二区三区不卡| 国产精品久久久久影院老司| 久久亚洲私人国产精品| 亚洲精品国产精品制服丝袜 | 婷婷色婷婷开心五月四房播播久久 | 中文字幕无码乱码人妻系列蜜桃| 寂寞少妇做spa按摩无码| 免费无码成人av在线播| 久久久精品中文字幕乱码18|