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  4. Recombinant Human C-type lectin domain family 4 member K (CD207), partial

Recombinant Human C-type lectin domain family 4 member K (CD207), partial

  • 中文名稱：
    Recombinant Human C-type lectin domain family 4 member K(CD207),partial
  • 貨號：
    CSB-YP892321HU
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human C-type lectin domain family 4 member K(CD207),partial
  • 貨號：
    CSB-EP892321HU
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human C-type lectin domain family 4 member K(CD207),partial
  • 貨號：
    CSB-EP892321HU-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human C-type lectin domain family 4 member K(CD207),partial
  • 貨號：
    CSB-BP892321HU
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human C-type lectin domain family 4 member K(CD207),partial
  • 貨號：
    CSB-MP892321HU
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    CD207
  • Uniprot No.：
  • 別名：
    C type lectin domain family 4 member K; C-type lectin domain family 4 member K; CD 207; CD207; CD207 antigen; CD207 antigen; langerin; CD207 molecule; CLC4K_HUMAN; CLEC 4K; CLEC4K; Langerhans cell specific c type lectin; Langerin; RGD1565913
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules (BGs); is a potent regulator of membrane superimposition and zippering. Binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. Facilitates uptake of antigens and is involved in the routing and/or processing of antigen for presentation to T cells. Major receptor on primary Langerhans cells for Candida species, Saccharomyces species, and Malassezia furfur. Protects against human immunodeficiency virus-1 (HIV-1) infection. Binds to high-mannose structures present on the envelope glycoprotein which is followed by subsequent targeting of the virus to the Birbeck granules leading to its rapid degradation.
  • 基因功能參考文獻：
    1. Binding analysis between purified long and short forms of langerin and a series of keratin sulfate disaccharide components shows that the binding critically requires the 6-sulfation of Gal and that the long form of langerin displays higher affinity than the short form. PMID: 29631057
    2. CD207(+)CD1a(+) cells are circulating in patients with active Langerhans cell histiocytosis, and TSLP and TGF-beta are potential drivers of Langerhans-like cells in vivo. PMID: 28847997
    3. the data provide evidence that human Langerhans cells are able to cross-present antigens after langerin-mediated internalization. PMID: 26456691
    4. Calcium-independent activation of an allosteric network in langerin by heparin oligosaccharides has been reported. PMID: 28198086
    5. Bacterial Polysaccharide Specificity of the Pattern Recognition Receptor Langerin Is Highly Species-dependent PMID: 27903635
    6. Kinetic and Structural Studies of Interactions between Glycosaminoglycans and Langerin PMID: 27447199
    7. We suggest that CD207 gene polymorphisms rs13421115 and rs17718987 increase the risk of development of end-stage renal disease. PMID: 27234728
    8. This study shows that mutations in the Langerin gene are present in the analysed populations at different genotypic and allelic frequencies and further studies should be conducted to verify the role of these mutations in HIV-1 susceptibility. PMID: 24676666
    9. This study is the first to demonstrate that langerin represents an authentic receptor that binds and internalizes influenza A virus to facilitate infection. PMID: 26468543
    10. Data suggest that Langerin (CD207)-mediated binding of Yersinia pestis to antigen-presenting cells (APCs) may promote its dissemination and infection. PMID: 25829141
    11. Langerin binds heparin (HEP)-like oligosaccharides in two different binding sites depending on the ligand size. PMID: 25747117
    12. The authors not only show that langerin and caveolin-1 co-localize at the cell membrane and in vesicles but that caveolin-1 mediated HIV-1 uptake is an intrinsic restriction mechanism present in human Langerhans cells that prevents HIV-1 infection. PMID: 25551286
    13. The impact of two carbohydrate recognition domains mutations, W264R and F241L, on langerin structure, function, and Birbeck granules assembly. PMID: 25650933
    14. Langerin is not expressed by freshly isolated CD1c(+) blood DCs but is rapidly induced on CD1c(+) DCs by serum or TGF-beta via an ALK-3-dependent pathway. PMID: 25516751
    15. Cell-sorting experiments demonstrated that IDO1 expression is found in a subset of CD1a(+)CD14(-)langerin(+) cells, expressing CD103 PMID: 25584868
    16. However, the superoxide dismutase C (SodC) protein of the Mycobacterium leprae cell wall was identified as a langerin-reactive ligand. PMID: 25422308
    17. Both phases of HIV transfer from eLCs to T cells were inhibited when eLCs were pretreated with a mAb to langerin CRD or when HIV was pretreated with a soluble langerin trimeric extracellular domain or by a CRD homolog. PMID: 25070850
    18. Altered langerin function in individuals with the linked N288D and K313I polymorphisms may affect susceptibility to infection by microorganisms. PMID: 24217250
    19. binding properties of langerin PMID: 23226363
    20. A langerin-cre recombinase transgenic knockin mouse strain is generated that efficiently targets Langerhans cells and other langerin-positive dendritic cells, in particular, in the dermis and the lung. PMID: 21998450
    21. measles virus receptor on Langergans cells PMID: 21739428
    22. Unlike selective Langerhans cell deficiency, ablation of all langerin-positive dendritic cells abrogates activation of IFN-gamma-producing and cytolytic CD8-positive T cells following gene gun vaccination. PMID: 21187444
    23. Crystal structures of the carbohydrate-recognition domain from langerin bound to oligomannoses, blood group B antigen, and a fragment of beta-glucan reveal binding to mannose, fucose, and glucose by Ca(2+) coordination of hydroxyl groups. PMID: 21112338
    24. Activation of CD8-positive T cells following intradermal plasmid DNA immunization depends on directly transfected langerin-positive dermal dendritic cells and dermal DCs. PMID: 20713888
    25. Trimeric structure of langerin. PMID: 20181944
    26. Langerin mediates diverse functions on Langerhans cells through dual recognition of sulfated as well as mannosylated glycans by its uniquely evolved C-type carbohydrate-recognition domain PMID: 20026605
    27. Langerin is the major fungal pathogen receptor on human Langerhans cells that recognizes pathogenic and commensal fungi. PMID: 20097424
    28. Data show that the expression of CD1a and CD207 is markedly down-regulated in CA epidermis. PMID: 19426597
    29. In a transgenic mouse model, the langerin-expressing subset of CD8alpha-positive dendritic cells is crucially involved in priming and differentiation of responses to cross-presented antigen. PMID: 19923446
    30. langerin was expressed by Langerhans cells PMID: 12352970
    31. Langerin is a potent langerhans cells -specific regulator of membrane superimposition and zippering, representing a key molecule to trace Langerhans cells [Review]. PMID: 14610287
    32. CD1a and langerin have roles in antigen presentation to T cells PMID: 14991068
    33. The Langerin-positive cells strictly colonized the epidermis and no cells were found in the dermis. PMID: 15222130
    34. Expression of mutated Langerin in human fibroblasts induces tubular-like structures that are negative for Birbeck granules-specific antibodies and do not resemble the characteristic structural features of Birbeck granules. PMID: 15816828
    35. Electron microscopy analysis demonstrated a colocalization of human papillomavirus 16 virus-like particles and langerin, which is expressed only by Langerhans cells PMID: 15831940
    36. The effects of the amino acid changes on the activity of langerin were examined by expressing each of the polymorphic forms. PMID: 16567809
    37. Langerin prevents HIV-1 transmission by Langernhans cells. PMID: 17334373
    38. Langerin transgenic mice have substantially reduced numbers of epidermal langerhans cells, demonstrating that TGFbeta1 acts directly on these cells. PMID: 17938236
    39. The carbohydrate-recognition domain of human Langerin was crystallized followed by X-ray analyses to resolutions of 2.5A for apo-Langerin and to 1.6A and 2.1A for the complexes with mannose and maltose, respectively. PMID: 18061677
    40. overproduction, purification and crystallization of the langerin carbohydrate binding domain is reported PMID: 18259063
    41. Immunohistochemical evaluation of langerin expression may have utility in substantiating a diagnosis of Langerhans cell histiocytosis and separating this disorder from other non-Langerhans cell histiocytic proliferations. PMID: 18277880
    42. Transgenic langerin effectively mediates antigen presentation in vivo by targeting its receptor in appropriate mouse dendritic cell subsets of draining lymph nodes and spleen; peptide major histocompatibility I and II complexes persist for days. PMID: 18322168

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  • 相關疾病：
    Birbeck granule deficiency (BIRGD)
  • 亞細胞定位：
    Membrane; Single-pass type II membrane protein. Note=Found in Birbeck granules (BGs), which are organelles consisting of superimposed and zippered membranes.
  • 組織特異性：
    Exclusively expressed by Langerhans cells. Expressed in astrocytoma and malignant ependymoma, but not in normal brain tissues.
  • 數據庫鏈接：

    HGNC: 17935

    OMIM: 604862

    KEGG: hsa:50489

    STRING: 9606.ENSP00000386378

    UniGene: Hs.199731



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