在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Butyrophilin subfamily 3 member A1 (BTN3A1), partial

  • 中文名稱:
    Recombinant Human Butyrophilin subfamily 3 member A1(BTN3A1),partial
  • 貨號:
    CSB-BP002873HU
  • 規(guī)格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    Recombinant Human Butyrophilin subfamily 3 member A1(BTN3A1),partial
  • 貨號:
    CSB-EP002873HU-B
  • 規(guī)格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    Recombinant Human Butyrophilin subfamily 3 member A1(BTN3A1),partial
  • 貨號:
    CSB-MP002873HU
  • 規(guī)格:
  • 來源:
    Mammalian cell
  • 其他:

產(chǎn)品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    Name:BTN3A1 Synonyms:BTF5
  • Uniprot No.:
  • 別名:
    BT3A1_HUMAN; BTN3A1; Butyrophilin subfamily 3 member A1; CD277
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Partial
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能:
    Plays a role in T-cell activation and in the adaptive immune response. Regulates the proliferation of activated T-cells. Regulates the release of cytokines and IFNG by activated T-cells. Mediates the response of T-cells toward infected and transformed cells that are characterized by high levels of phosphorylated metabolites, such as isopentenyl pyrophosphate.
  • 基因功能參考文獻:
    1. Microtubule-associated protein 4 (MAP4) controls the dynein-dependent transport of BTN3A1 in response to nucleic acid stimulation, thereby identifying MAP4 as an upstream regulator of BTN3A1. Thus, the depletion of either MAP4 or BTN3A1 impairs cytosolic DNA- or RNA-mediated type I IFN responses. PMID: 27911820
    2. results show that ligand binding to BTN3A1 induces a conformational change within the intracellular domain that involves the JM region and is required for full activation. PMID: 28705810
    3. findings show that changes in the juxtamembrane domain of BTN3A1, but not its transmembrane domain, induce a markedly enhanced or reduced gammadelta T cell reactivity PMID: 28461569
    4. These findings support intracellular sensing of prenyl pyrophosphates by BTN3A1 rather than extracellular presentation. PMID: 26475929
    5. Human gamma-delta T cells are activated by cytosolic interactions of BTN3A1 with soluble phosphoantigens and the cytoskeletal adaptor periplakin. PMID: 25637025
    6. evidence that gene(s) on Chr6 in addition to BTN3A1 are mandatory for PAg-mediated activation of Vgamma9Vdelta2 T cells. PMID: 24890657
    7. Ligand binding to the BTN3A1 B30.2 domain affects residues in the juxtamembrane region, suggesting ligand-induced conformational change. PMID: 25065532
    8. These studies demonstrate that internal sensing of changes in pAg metabolite concentrations by BTN3A1 molecules is a critical step in Vgamma9Vdelta2 T cell detection of infection and tumorigenesis. PMID: 24703779
    9. BTN3A1 represents an antigen-presenting molecule required for the activation of Vgamma9Vdelta2 T cells. PMID: 23872678
    10. investigation of role of CD277 in activation/inactivation of T-lymphocytes: Data indicate that modulation of CD277 interaction (with agonists or blocking antibodies) with T-cell antigen receptor can modulate activation/inactivation of T-lymphocytes. PMID: 22767497
    11. BTN3A1 is necessary for Vgamma9Vdelta2 activation and begin to unravel the extracellular events that occur during stimulation through the Vgamma9Vdelta2 T cell receptor. PMID: 22846996
    12. CD277 triggering is not involved in CD16- or NKp46-induced NK cell activation. PMID: 21918970
    13. Results point to a role for CD277 up-regulated by microenvironmental signals in the acquisition of a regulatory phenotype by ovarian tumor-associated myeloid cells. PMID: 21113407

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Single-pass type I membrane protein.
  • 蛋白家族:
    Immunoglobulin superfamily, BTN/MOG family
  • 組織特異性:
    Detected on T-cells, natural killer cells, dendritic cells and macrophages (at protein level). Ubiquitous. Highly expressed in heart, pancreas and lung, Moderately expressed in placenta, liver and muscle.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 1138

    OMIM: 613593

    KEGG: hsa:11119

    STRING: 9606.ENSP00000289361

    UniGene: Hs.191510



主站蜘蛛池模板: 先锋影音最新色资源站| 欧美搡bbbbb搡bbbbb| 宅男色影视亚洲人在线| 国产九九九九九九九a片| 麻豆精品导航| 中年人妻丰满av无码久久不卡| 国产萌白酱喷水视频在线播放| 人妻中文乱码在线网站| 国产丝袜美女一区二区三区| 亚洲人成小说网站色在线| 国精品午夜福利视频| 国产交换配偶在线视频| 国产成人久久婷婷精品流白浆| 中文幕无线码中文字夫妻| 丝袜老师高潮呻吟高潮| av天堂亚洲区无码先锋影音| 无码毛片视频一区二区本码 | 亚洲人成在线观看影院牛大爷| 亚洲精品国产av成拍色拍婷婷 | 国产成 人 综合 亚洲专区| 亚洲欧美国产制服图片区| 国产福利视频在线观看| 久久国产avjust麻豆| 国产99青草视频在线播放视| 三级做爰高清视频| 97久久精品无码一区二区天美| 中文精品久久久久人妻| 亚洲欧美偷拍另类a∨| 欧洲精品免费一区二区三区| 亚洲精品92内射| 一本大道久久东京热av| 中文字幕亚洲码在线| 欧洲乱码伦视频免费| 亚洲日韩精品一区二区三区无码 | 亚洲日韩欧洲无码av夜夜摸| 天下第一社区视频www日本| 欧美人妻精品一区二区三区| 婷婷久久综合九色综合| 国产按头口爆吞精在线视频| 色 综合 欧美 亚洲 国产| 无码av中文字幕久久专区|