在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Biogenesis of lysosome-related organelles complex 1 subunit 1 (BLOC1S1)

  • 中文名稱:
    Recombinant Human Biogenesis of lysosome-related organelles complex 1 subunit 1(BLOC1S1)
  • 貨號:
    CSB-YP002718HU
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    Recombinant Human Biogenesis of lysosome-related organelles complex 1 subunit 1(BLOC1S1)
  • 貨號:
    CSB-EP002718HU
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    Recombinant Human Biogenesis of lysosome-related organelles complex 1 subunit 1(BLOC1S1)
  • 貨號:
    CSB-EP002718HU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    Recombinant Human Biogenesis of lysosome-related organelles complex 1 subunit 1(BLOC1S1)
  • 貨號:
    CSB-BP002718HU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    Recombinant Human Biogenesis of lysosome-related organelles complex 1 subunit 1(BLOC1S1)
  • 貨號:
    CSB-MP002718HU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    BLOC1S1
  • Uniprot No.:
  • 別名:
    BLOC1S1; BLOS1; GCN5L1; RT14Biogenesis of lysosome-related organelles complex 1 subunit 1; BLOC-1 subunit 1; GCN5-like protein 1; Protein RT14
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Full length protein
  • 表達區域:
    1-153
  • 氨基酸序列
    MAPGSRGERS SFRSRRGPGV PSPQPDVTML SRLLKEHQAK QNERKELQEK RRREAITAAT CLTEALVDHL NVGVAQAYMN QRKLDHEVKT LQVQAAQFAK QTGQWIGMVE NFNQALKEIG DVENWARSIE LDMRTIATAL EYVYKGQLQS APS
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor.; May negatively regulate aerobic respiration through mitochondrial protein lysine-acetylation. May counteract the action of the deacetylase SIRT3 by acetylating and regulating proteins of the mitochondrial respiratory chain including ATP5F1A and NDUFA9.
  • 基因功能參考文獻:
    1. The Hermansky-Pudlak syndrome complex BLOC-1 and its cargo PI4KIIalpha interact with regulators of the actin cytoskeleton. PMID: 23676666
    2. BLOS1 interacts with KXD1. PMID: 22554196
    3. GCN5L1 interacts with and promotes acetylation of SIRT3 respiratory chain targets and reverses global SIRT3 effects on mitochondrial protein acetylation, respiration and bioenergetics PMID: 22309213
    4. Quantitative proteomic studies expand the functional repertoire of the BLOC-1 complex and provide insight into putative molecular pathways of schizophrenia susceptibility. PMID: 22423091
    5. GCN5L1/BLOC1S1 regulates lysine acetylation in mitochondria. PMID: 22309213
    6. Together this study data provide evidence for the involvement of the BLOC-1 protein complex in SZ pathogenesis. PMID: 17618940
    7. Experimental investigation of five specific genes, AP3B1, ATP6AP1, BLOC1S1, LAMP2, and RAB11A, has confirmed novel roles for these proteins in the proper initiation of macroautophagy in amino acid-starved fibroblasts. PMID: 19246570
    8. Biogenesis of Lysosome-related Organelles complex-1 (BLOC-1) subunit 1 (BLOS1). PMID: 15102850

    顯示更多

    收起更多

  • 亞細胞定位:
    Mitochondrion intermembrane space. Mitochondrion matrix. Cytoplasm, cytosol. Lysosome membrane.
  • 蛋白家族:
    BLOC1S1 family
  • 數據庫鏈接:

    HGNC: 4200

    OMIM: 601444

    KEGG: hsa:2647

    STRING: 9606.ENSP00000447537

    UniGene: Hs.600940



主站蜘蛛池模板: 一区二区三区无码按摩精油| 亚洲日韩片无码中文字幕| 久久亚洲精品成人无码网站夜色 | 欧美亚洲精品中文字幕乱码| 亚洲伊人久久大香线蕉综合图片| 天堂va欧美va亚洲va好看va| 精品成人毛片一区二区| 色综合久久久无码网中文| 亚洲欧美国产精品久久久久久久 | 一道精品视频一区二区三区 | 国产午夜高潮熟女精品av软件 | 亚洲国产成人精品无码区99| 少妇的肉体k8经典| 欧洲女人牲交性开放视频| 最新在线精品国自产拍视频| 国产精品美女久久久网站| 无码精品人妻一区二区三区漫画| 午夜福利国产成人无码gif动图| 免费女人裸体视频无遮挡免费网站 | 国产精品第12页| 婷婷开心激情综合五月天| 97se狠狠狠狠狼鲁亚洲综合色| 牛和人交videos欧美| 亚洲夂夂婷婷色拍ww47| 中文字幕亚洲色妞精品天堂| 欧美又粗又大又黄的片| 欧洲免费一区二区三区视频| 丰满人妻中伦妇伦精品app| 国产精品无码久久久久| 亚洲综合色婷婷六月丁香宅男大增| 免费视频好湿好紧好大好爽| 一个人在线观看免费视频www| 狠狠色丁香婷婷综合潮喷| 久久久久久人妻毛片a片| 中国大陆精品视频xxxx| 婷婷四房播播| 免费国产在线一区二区| 日本一卡二卡3卡四卡网站精品| 国产露脸无套对白在线播放| 天天做天天躁天天躁| 国产乱人伦偷精品视频免|