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  4. Recombinant Human Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial (MTHFD2)

Recombinant Human Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial (MTHFD2)

  • 中文名稱：
    人MTHFD2重組蛋白
  • 貨號(hào)：
    CSB-YP015156HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人MTHFD2重組蛋白
  • 貨號(hào)：
    CSB-EP015156HU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人MTHFD2重組蛋白
  • 貨號(hào)：
    CSB-EP015156HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人MTHFD2重組蛋白
  • 貨號(hào)：
    CSB-BP015156HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人MTHFD2重組蛋白
  • 貨號(hào)：
    CSB-MP015156HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    MTHFD2
  • Uniprot No.：
  • 別名：
    Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase; mitochondrial; Descriptions; Methenyltetrahydrofolate cyclohydrolase; methylene tetrahydrofolate dehydrogenase (NAD+ dependent); methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2; methylenetetrahydrofolate dehydrogenase (NADP+ dependent); methylenetetrahydrofolate dehydrogenase 2; MGC82516; MTDC_HUMAN; MTHFD2; mthfd2 methylene tetrahydrofolate dehydrogenase (NAD+ dependent); NAD-dependent methylene tetrahydrofolate dehydrogenase; NAD-dependent methylenetetrahydrofolate dehydrogenase; NMDMC
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達(dá)區(qū)域：
    36-350
  • 氨基酸序列
    EAVVI SGRKLAQQIK QEVRQEVEEW VASGNKRPHL SVILVGENPA SHSYVLNKTR AAAVVGINSE TIMKPASISE EELLNLINKL NNDDNVDGLL VQLPLPEHID ERRICNAVSP DKDVDGFHVI NVGRMCLDQY SMLPATPWGV WEIIKRTGIP TLGKNVVVAG RSKNVGMPIA MLLHTDGAHE RPGGDATVTI SHRYTPKEQL KKHTILADIV ISAAGIPNLI TADMIKEGAA VIDVGINRVH DPVTAKPKLV GDVDFEGVRQ KAGYITPVPG GVGPMTVAML MKNTIIAAKK VLRLEEREVL KSKELGVATN
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Although its dehydrogenase activity is NAD-specific, it can also utilize NADP at a reduced efficiency.
  • 基因功能參考文獻(xiàn)：
    1. endothelial cells undergo MTHFD2-mediated reprogramming toward serine-glycine and mitochondrial one-carbon metabolism to compensate for the loss of ATP in response to oxidized phospholipids during atherosclerosis PMID: 29895827
    2. Knocking down MTHFD2 expression in renal cell carcinoma cells, decreased cell proliferation, migration, and invasion were observed and accompanied by the reduced expression of vimentin. PMID: 30466107
    3. miR-92a inhibits proliferation and induces apoptosis by directly regulating MTHFD2 expression in AML. PMID: 28059050
    4. metabolic alterations in MCF7 cells observed as a consequence of MTHFD2 suppression PMID: 27315223
    5. crystal structure of MTHFD2 in complex with a substrate-based inhibitor and the enzyme cofactors NAD(+) and inorganic phosphate. PMID: 27899380
    6. Mechanistically, MYC regulates the expression of MTHFD2, and MTHFD2 knockdown suppresses the TCA cycle. PMID: 27325891
    7. siRNA-mediated silencing of MTHFD2 inhibited migration, invasion and epithelial-mesenchymal transition progression in hepatocellular carcinoma (HCC) cell lines, but no obvious effects on cell proliferation, apoptosis or cell cycle distribution were detected. MTHFD2 is overexpressed in HCC, and is associated with poor prognosis and cellular features connected to metastatic disease. PMID: 27257051
    8. These findings suggest a previously unknown role for MTHFD2 in cancer cell proliferation, adding to its known function in mitochondrial folate metabolism. PMID: 26461067
    9. The highest scoring pathway is mitochondrial one-carbon metabolism and is centred on MTHFD2. PMID: 24451681
    10. Data indicate that methylenetetrahydrofolate dehydrogenase (NADP + -dependent) 2 (MTHFD2)was differentially expressed in breast cancer tissue, suggesting as a prognostic factor and a potential therapeutic target for future breast cancer treatments. PMID: 24870594
    11. Data indicate that the reduced vimentin expression in response to EPHB4, WIPF2 and MTHFD2 silencing was observed at mRNA and protein levels. PMID: 23295955

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  • 亞細(xì)胞定位：
    Mitochondrion.
  • 蛋白家族：
    Tetrahydrofolate dehydrogenase/cyclohydrolase family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 7434

    OMIM: 604887

    KEGG: hsa:10797

    STRING: 9606.ENSP00000377617

    UniGene: Hs.469030



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