在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

MTHFD2 Antibody

  • 中文名稱:
    MTHFD2兔多克隆抗體
  • 貨號:
    CSB-PA015156ESR2HU
  • 規格:
    ¥440
  • 圖片:
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA015156ESR2HU at dilution of 1:100
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) MTHFD2 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    MTHFD2
  • 別名:
    Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase; mitochondrial antibody; Descriptions antibody; Methenyltetrahydrofolate cyclohydrolase antibody; methylene tetrahydrofolate dehydrogenase (NAD+ dependent) antibody; methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 antibody; methylenetetrahydrofolate dehydrogenase (NADP+ dependent) antibody; methylenetetrahydrofolate dehydrogenase 2 antibody; MGC82516 antibody; MTDC_HUMAN antibody; MTHFD2 antibody; mthfd2 methylene tetrahydrofolate dehydrogenase (NAD+ dependent) antibody; NAD-dependent methylene tetrahydrofolate dehydrogenase antibody; NAD-dependent methylenetetrahydrofolate dehydrogenase antibody; NMDMC antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial protein (40-250AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Although its dehydrogenase activity is NAD-specific, it can also utilize NADP at a reduced efficiency.
  • 基因功能參考文獻:
    1. endothelial cells undergo MTHFD2-mediated reprogramming toward serine-glycine and mitochondrial one-carbon metabolism to compensate for the loss of ATP in response to oxidized phospholipids during atherosclerosis PMID: 29895827
    2. Knocking down MTHFD2 expression in renal cell carcinoma cells, decreased cell proliferation, migration, and invasion were observed and accompanied by the reduced expression of vimentin. PMID: 30466107
    3. miR-92a inhibits proliferation and induces apoptosis by directly regulating MTHFD2 expression in AML. PMID: 28059050
    4. metabolic alterations in MCF7 cells observed as a consequence of MTHFD2 suppression PMID: 27315223
    5. crystal structure of MTHFD2 in complex with a substrate-based inhibitor and the enzyme cofactors NAD(+) and inorganic phosphate. PMID: 27899380
    6. Mechanistically, MYC regulates the expression of MTHFD2, and MTHFD2 knockdown suppresses the TCA cycle. PMID: 27325891
    7. siRNA-mediated silencing of MTHFD2 inhibited migration, invasion and epithelial-mesenchymal transition progression in hepatocellular carcinoma (HCC) cell lines, but no obvious effects on cell proliferation, apoptosis or cell cycle distribution were detected. MTHFD2 is overexpressed in HCC, and is associated with poor prognosis and cellular features connected to metastatic disease. PMID: 27257051
    8. These findings suggest a previously unknown role for MTHFD2 in cancer cell proliferation, adding to its known function in mitochondrial folate metabolism. PMID: 26461067
    9. The highest scoring pathway is mitochondrial one-carbon metabolism and is centred on MTHFD2. PMID: 24451681
    10. Data indicate that methylenetetrahydrofolate dehydrogenase (NADP + -dependent) 2 (MTHFD2)was differentially expressed in breast cancer tissue, suggesting as a prognostic factor and a potential therapeutic target for future breast cancer treatments. PMID: 24870594
    11. Data indicate that the reduced vimentin expression in response to EPHB4, WIPF2 and MTHFD2 silencing was observed at mRNA and protein levels. PMID: 23295955

    顯示更多

    收起更多

  • 亞細胞定位:
    Mitochondrion.
  • 蛋白家族:
    Tetrahydrofolate dehydrogenase/cyclohydrolase family
  • 數據庫鏈接:

    HGNC: 7434

    OMIM: 604887

    KEGG: hsa:10797

    STRING: 9606.ENSP00000377617

    UniGene: Hs.469030



主站蜘蛛池模板: 无码综合天天久久综合网色吧影院| 亚洲精品永久在线观看| 男女做爰猛烈叫床视频免费| 国模大胆一区二区三区| 日韩精品无码一本二本三本色| 国产人妻久久精品二区三区| 日本免费高清一本视频| 狠狠色噜噜狠狠狠7777奇米| 日本不卡三区| 国产精品69人妻无码久久| 国产欧美在线亚洲一区| 久久久久免费精品国产| 久久婷婷五月综合色中文字幕| 精品无人区一区二区三区| 饥渴少妇做私密保健视频| 色五月丁香五月综合五月| 亚洲最大成人网站| 四虎精品成人免费视频| 最新高清中文字幕免费mv| 日本19禁啪啪吃奶大尺度| 色香欲综合成人免费视频| 久久精品aⅴ无码中文字字幕重口| 无码专区天天躁天天躁在线| 色舞月亚洲综合一区二区| 久久精品国产免费播| 黄页网址大全免费观看| 乱码人妻一区二区三区| 狠狠躁夜夜躁无码中文字幕| 亚洲欧美日韩另类丝袜一区| 内射人妻少妇无码一本一道| 日本乱妇乱子视频网站-百度| 亚洲国产综合av在线观看| 国产一区丝袜高跟鞋| 亚洲 日本 欧美 中文幕| 亚洲性无码av在线欣赏网| 国产午夜无码片免费| 中文字幕av无码免费一区| 无码无套少妇毛多69xxx| 国产产无码乱码精品久久鸭 | 人妻夜夜爽天天爽三区麻豆av网站 | 无码人妻精品一区二|