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  4. Recombinant Human Beta-parvin (PARVB)

Recombinant Human Beta-parvin (PARVB)

  • 中文名稱：
    人PARVB重組蛋白
  • 貨號：
    CSB-YP875712HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人PARVB重組蛋白
  • 貨號：
    CSB-EP875712HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人PARVB重組蛋白
  • 貨號：
    CSB-EP875712HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人PARVB重組蛋白
  • 貨號：
    CSB-BP875712HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人PARVB重組蛋白
  • 貨號：
    CSB-MP875712HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    PARVB; CGI-56; Beta-parvin; Affixin
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    full length protein
  • 表達區域：
    1-364
  • 氨基酸序列
    MSSAPRSPTP RPRRMKKDES FLGKLGGTLA RKRRAREVSD LQEEGKNAIN SPMSPALVDV HPEDTQLEEN EERTMIDPTS KEDPKFKELV KVLLDWINDV LVEERIIVKQ LEEDLYDGQV LQKLLEKLAG CKLNVAEVTQ SEIGQKQKLQ TVLEAVHDLL RPRGWALRWS VDSIHGKNLV AILHLLVSLA MHFRAPIRLP EHVTVQVVVV RKREGLLHSS HISEELTTTT EMMMGRFERD AFDTLFDHAP DKLSVVKKSL ITFVNKHLNK LNLEVTELET QFADGVYLVL LMGLLEDYFV PLHHFYLTPE SFDQKVHNVS FAFELMLDGG LKKPKARPED VVNLDLKSTL RVLYNLFTKY KNVE
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Adapter protein that plays a role in integrin signaling via ILK and in activation of the GTPases CDC42 and RAC1 by guanine exchange factors, such as ARHGEF6. Is involved in the reorganization of the actin cytoskeleton and formation of lamellipodia. Plays a role in cell adhesion, cell spreading, establishment or maintenance of cell polarity, and cell migration.
  • 基因功能參考文獻：
    1. PARVB protein PMID: 25776890
    2. Protein expression of beta-Parvin increases with colorectal cancer progression. PMID: 26115385
    3. Taken together, our results indicate that 24-MCF treatment increases parvin-beta expression, which may inhibit ILK downstream signaling. PMID: 26549231
    4. study found polymorphisms of rs5764455 and rs6006473 in PARVB gene in the Han Chinese population, and these polymorphisms were associated with the occurrence and progression of NAFLD. PMID: 26343796
    5. Our results suggested that variations, including insertion/deletions, in PARVB, as well as those in PNPLA3, are important in the progression of NAFLD. PMID: 24621583
    6. PARVB overexpression is a candidate biomarker for endophytic tumours and metastasis. PMID: 25422907
    7. PARVB plays a potential role in the pathogenesis of coronary restenosis. PMID: 23950981
    8. alpha-parvin, beta-parvin and migfilin were expressed in tumor cells in 53%, 2%, 28% and 53% of effusions and 57%, 20%, 83% and 25% of solid lesions, respectively. PMID: 23099104
    9. proper localization of beta-parvin to focal adhesions requires both the paxillin and integrin-linked kinase binding sites and that paxillin is important for early targeting of beta-parvin. PMID: 22869380
    10. Legionella pneumophila F-box protein Lpp2082 (AnkB) modulates ubiquitination of the host protein parvin B and promotes intracellular replication. PMID: 20345489
    11. downexpression of ParvB level in urothelial cell carcinoma of the upper urinary tract (UUT-UC) correlated with tumour stage, and was an independent unfavourable prognostic factor for disease-specific survival of patients with UUT-UC PMID: 20736946
    12. Data from functional molecular imaging demonstrated that beta-parvin plays a regulatory role in the ILK-mediated Akt (also called protein kinase B) signaling cascades, suggesting that beta-parvin might be a crucial modulator of cell survival. PMID: 20164304
    13. Mammalian parvins are likely to have arisen late in evolution from gene duplication as they share a remarkably similar exon/intron organization. PMID: 11722847
    14. the ILK-affixin complex has a role in integrin-cytoskeleton linkage during platelet aggregation [affixin] PMID: 12372433
    15. affixin provide a novel signalling pathway that links integrin signalling to Cdc42/Rac1 activation. PMID: 15005707
    16. ILK-affixin complex serves as an integrin-anchoring site for alpha-actinin and thereby mediates integrin signaling to alpha-actinin, which has been shown to play a critical role in actin polymerization at focal adhesions. PMID: 15159419
    17. alpha- and beta-parvins play distinct roles in Rac activation or lamellipodium formation and protection of cells from apoptosis. PMID: 15284246
    18. loss of ParvB expression is a novel mechanism for upregulating ILK activity in tumors PMID: 15467740
    19. Data show that affixin is a dysferlin binding protein that colocalizes with dysferlin at the sarcolemma of normal skeletal muscle. PMID: 15835269
    20. Parvin-beta might influence breast cancer progression PMID: 17998334
    21. results suggest that affixin is involved in reorganization of subsarcolemmal cytoskeletal actin by activation of Rac1 through alpha and betaPIXs in skeletal muscle PMID: 18325335

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  • 亞細胞定位：
    Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Cytoplasm, myofibril, sarcomere. Cytoplasm, myofibril, sarcomere, Z line. Note=Constituent of focal adhesions. Detected at the tips of the leading edge of cells. Colocalizes with F-actin at the tips of lamellipodia.
  • 蛋白家族：
    Parvin family
  • 組織特異性：
    Expressed predominantly in heart and skeletal muscle.
  • 數據庫鏈接：

    HGNC: 14653

    OMIM: 608121

    KEGG: hsa:29780

    STRING: 9606.ENSP00000384515

    UniGene: Hs.475074



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