在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Autophagy-related protein 2 homolog B (ATG2B), partial

  • 中文名稱:
    Recombinant Human Autophagy-related protein 2 homolog B(ATG2B) ,partial
  • 貨號:
    CSB-YP822186HU
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    Recombinant Human Autophagy-related protein 2 homolog B(ATG2B) ,partial
  • 貨號:
    CSB-EP822186HU
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    Recombinant Human Autophagy-related protein 2 homolog B(ATG2B) ,partial
  • 貨號:
    CSB-EP822186HU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    Recombinant Human Autophagy-related protein 2 homolog B(ATG2B) ,partial
  • 貨號:
    CSB-BP822186HU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    Recombinant Human Autophagy-related protein 2 homolog B(ATG2B) ,partial
  • 貨號:
    CSB-MP822186HU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    2410024A21Rik; AI047755; AI503411; ATG2 autophagy related 2 homolog B; Atg2b; ATG2B_HUMAN; Autophagy-related protein 2 homolog B; AW558123; C030004M05Rik; C14orf103; C630028L02Rik; FLJ10242; KIAA4067; mKIAA4067
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Partial
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Lipid transfer protein required for both autophagosome formation and regulation of lipid droplet morphology and dispersion. Tethers the edge of the isolation membrane (IM) to the endoplasmic reticulum (ER) and mediates direct lipid transfer from ER to IM for IM expansion. Binds to the ER exit site (ERES), which is the membrane source for autophagosome formation, and extracts phospholipids from the membrane source and transfers them to ATG9 (ATG9A or ATG9B) to the IM for membrane expansion. Lipid transfer activity is enhanced by WDR45/WIPI4, which promotes ATG2B-association with phosphatidylinositol 3-monophosphate (PI3P)-containing membranes.
  • 基因功能參考文獻:
    1. Authors demonstrate that inhibition of autophagosome completion by Atg2A/B deletion accumulates immature autophagosomal membranes that promote non-canonical caspase-8 activation in response to nutrient starvation via an intracellular death-inducing signaling complex (iDISC). PMID: 28800131
    2. This study highlights the transcriptional inactivation mechanisms of ATG2B, ATG4D, ATG9A and ATG9B promoter methylation status and the possible origin of autophagy signal pathway repression in invasive ductal carcinomas. PMID: 27265029
    3. demonstrate that overexpression of ATG2B and GSKIP enhances hematopoietic progenitor differentiation, including of megakaryocytes, by increasing progenitor sensitivity to thrombopoietin PMID: 26280900
    4. miR-143 inhibits cell proliferation by targeting autophagy-related 2B in non-small cell lung cancer H1299 cells. PMID: 25322940
    5. Depletion of both Atg2A and Atg2B causes clustering of enlarged lipid droplets in an autophagy-independent manner. These data suggest that mammalian Atg2 proteins function both in autophagosome formation and regulation of lipid droplet morphology and dispersion. PMID: 22219374
    6. miR-130a inhibited autophagy by reducing autophagosome formation, an effect mediated by downregulation of the genes ATG2B and DICER1. PMID: 22350415

    顯示更多

    收起更多

  • 亞細胞定位:
    Preautophagosomal structure membrane; Peripheral membrane protein. Lipid droplet. Endoplasmic reticulum membrane; Peripheral membrane protein.
  • 蛋白家族:
    ATG2 family
  • 數據庫鏈接:

    HGNC: 20187

    OMIM: 616226

    KEGG: hsa:55102

    STRING: 9606.ENSP00000353010

    UniGene: Hs.168241



主站蜘蛛池模板: xx性欧美肥妇精品久久久久久| 欧美乱妇高清无乱码免费| 少妇熟女视频一区二区三区 | 中文字幕 人妻熟女| 日本中文字幕有码在线视频| 国产久热精品无码激情| 人人爽人人模人人人爽人人爱| 欧美乱大交xxxxx潮喷| 一二三四视频社区3在线高清| 十八禁午夜福利免费网站| 久久精品人人做人人爱爱漫画| 久久国产精品无码网站| 国产精品高清一区二区三区| k频道国产在线观看| 日韩精品一区二区三区vr| 久久er99国产精品免费 | 久久亚洲精品国产精品777777| 亚洲成本人无码薄码区| 久久精品伊人一区二区三区| 亚洲a∨无码男人的天堂| 成年丰满熟妇午夜免费视频| 色一情一乱一伦一区二区三区| 午夜福利无遮挡十八禁视频| 丁香狠狠色婷婷久久综合| 自拍偷在线精品自拍偷免费 | 国产麻豆一精品一av一免费| 激情五月综合色婷婷一区二区| 俄罗斯老熟妇色xxxx| 亚洲欧洲精品成人久久曰影片| 大陆国语对白国产av片| 又紧又大又爽精品一区二区 | 免费h动漫无码网站| 欧美人与动性行为视频| 亚洲色成人www永久在线观看| 久久丫精品久久丫| 色喜国模李晴超大尺度| 日本大片免费观看视频| 国产日韩av在线播放| 中文字幕乱码中文乱码777 | 少妇被躁爽到高潮无码久久| 国产av精国产传媒|