在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Autophagy-related protein 2 homolog B (ATG2B), partial

  • 中文名稱:
    Recombinant Human Autophagy-related protein 2 homolog B(ATG2B) ,partial
  • 貨號:
    CSB-YP822186HU
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    Recombinant Human Autophagy-related protein 2 homolog B(ATG2B) ,partial
  • 貨號:
    CSB-EP822186HU
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    Recombinant Human Autophagy-related protein 2 homolog B(ATG2B) ,partial
  • 貨號:
    CSB-EP822186HU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    Recombinant Human Autophagy-related protein 2 homolog B(ATG2B) ,partial
  • 貨號:
    CSB-BP822186HU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    Recombinant Human Autophagy-related protein 2 homolog B(ATG2B) ,partial
  • 貨號:
    CSB-MP822186HU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    2410024A21Rik; AI047755; AI503411; ATG2 autophagy related 2 homolog B; Atg2b; ATG2B_HUMAN; Autophagy-related protein 2 homolog B; AW558123; C030004M05Rik; C14orf103; C630028L02Rik; FLJ10242; KIAA4067; mKIAA4067
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Partial
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Lipid transfer protein required for both autophagosome formation and regulation of lipid droplet morphology and dispersion. Tethers the edge of the isolation membrane (IM) to the endoplasmic reticulum (ER) and mediates direct lipid transfer from ER to IM for IM expansion. Binds to the ER exit site (ERES), which is the membrane source for autophagosome formation, and extracts phospholipids from the membrane source and transfers them to ATG9 (ATG9A or ATG9B) to the IM for membrane expansion. Lipid transfer activity is enhanced by WDR45/WIPI4, which promotes ATG2B-association with phosphatidylinositol 3-monophosphate (PI3P)-containing membranes.
  • 基因功能參考文獻:
    1. Authors demonstrate that inhibition of autophagosome completion by Atg2A/B deletion accumulates immature autophagosomal membranes that promote non-canonical caspase-8 activation in response to nutrient starvation via an intracellular death-inducing signaling complex (iDISC). PMID: 28800131
    2. This study highlights the transcriptional inactivation mechanisms of ATG2B, ATG4D, ATG9A and ATG9B promoter methylation status and the possible origin of autophagy signal pathway repression in invasive ductal carcinomas. PMID: 27265029
    3. demonstrate that overexpression of ATG2B and GSKIP enhances hematopoietic progenitor differentiation, including of megakaryocytes, by increasing progenitor sensitivity to thrombopoietin PMID: 26280900
    4. miR-143 inhibits cell proliferation by targeting autophagy-related 2B in non-small cell lung cancer H1299 cells. PMID: 25322940
    5. Depletion of both Atg2A and Atg2B causes clustering of enlarged lipid droplets in an autophagy-independent manner. These data suggest that mammalian Atg2 proteins function both in autophagosome formation and regulation of lipid droplet morphology and dispersion. PMID: 22219374
    6. miR-130a inhibited autophagy by reducing autophagosome formation, an effect mediated by downregulation of the genes ATG2B and DICER1. PMID: 22350415

    顯示更多

    收起更多

  • 亞細胞定位:
    Preautophagosomal structure membrane; Peripheral membrane protein. Lipid droplet. Endoplasmic reticulum membrane; Peripheral membrane protein.
  • 蛋白家族:
    ATG2 family
  • 數據庫鏈接:

    HGNC: 20187

    OMIM: 616226

    KEGG: hsa:55102

    STRING: 9606.ENSP00000353010

    UniGene: Hs.168241



主站蜘蛛池模板: 2024av天堂手机在线观看| 九九久久精品无码专区| 无码av高潮抽搐流白浆| 午夜精品久久久久久久爽| 国产无遮挡a片无码免费| 国产又爽又黄又不遮挡视频| 国产成人综合在线女婷五月99播放 | 无码国产伦一区二区三区视频| 国产亚洲精品久久久ai换| 永久黄网站免费视频性色| 无码任你躁久久久久久老妇蜜桃| 最新国产成人无码久久| 老头把我添高潮了a片| 中文字幕乱码亚洲无线三区 | 波多野结衣av在线观看| 国精产品一二三区精华液| www插插插无码视频网站| 国产一区二区无码蜜芽精品| 精品一卡2卡三卡4卡乱码精品视频| 成人网站国产在线视频内射视频| 特级毛片a片久久久久久| 人妻色综合网站| 国产肉体xxxx裸体137大胆| 欧美人与动人物姣配xxxx| 天堂www中文资源| 中文字幕av免费专区| 2020精品国产自在现线看| 亚洲337少妇裸体艺术| 六十熟妇乱子伦视频| 久久久国产精品麻豆a片| 少妇的肉体aa片免费| 久久久久国产精品人妻| 亚洲欧美日韩中文播放| 2018年秋霞无码片| 在线日韩av免费永久观看| 国产精品自产拍高潮在线观看| 未满十八18禁止免费无码网站| 日本免费一区二区三区日本| 欲女熟妇国产一区二区| 一本大道伊人av久久综合| 久久久性色精品国产免费观看|