在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Aspartoacylase (ASPA)

In Stock
  • 中文名稱:
    Recombinant Human Aspartoacylase(ASPA)
  • 貨號:
    CSB-YP002223HU
  • 規格:
    ¥2208
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產品詳情

  • 純度:
    Greater than 85% as determined by SDS-PAGE.
  • 基因名:
  • Uniprot No.:
  • 別名:
    ACY 2; ACY-2; ACY2; ACY2_HUMAN; Aminoacylase 2; Aminoacylase-2; Aminoacylase2; ASP; ASPA; Aspartoacylase (aminoacylase 2; Canavan disease); Aspartoacylase (Canavan disease); Aspartoacylase; NUR 7; NUR7; OTTMUSP00000006437; RP23-213I10.1; Small lethargic
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Full Length
  • 來源:
    Yeast
  • 分子量:
    39.7 kDa
  • 表達區域:
    1-313aa
  • 氨基酸序列
    MTSCHIAEEHIQKVAIFGGTHGNELTGVFLVKHWLENGAEIQRTGLEVKPFITNPRAVKKCTRYIDCDLNRIFDLENLGKKMSEDLPYEVRRAQEINHLFGPKDSEDSYDIIFDLHNTTSNMGCTLILEDSRNNFLIQMFHYIKTSLAPLPCYVYLIEHPSLKYATTRSIAKYPVGIEVGPQPQGVLRADILDQMRKMIKHALDFIHHFNEGKEFPPCAIEVYKIIEKVDYPRDENGEIAAIIHPNLQDQDWKPLHPGDPMFLTLDGKTIPLGGDCTVYPVFVNEAAYYEKKEAFAKTTKLTLNAKSIRCCLH
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 10xHis-tagged and C-terminal Myc-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Tris-based buffer,50% glycerol
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    3-7 business days
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Catalyzes the deacetylation of N-acetylaspartic acid (NAA) to produce acetate and L-aspartate. NAA occurs in high concentration in brain and its hydrolysis NAA plays a significant part in the maintenance of intact white matter. In other tissues it act as a scavenger of NAA from body fluids.
  • 基因功能參考文獻:
    1. report of 2 Egyptian sibling patients suspected of Canavan disease (CD); study revealed homozygosity for substitution T530C (Ile177Thr) in exon 4 of the ASPA gene in both sibs; substitution T530C (Ile177Thr) results in a novel missense mutation causing a CD phenotype with severe clinical characteristics PMID: 24036223
    2. Four ASPA missense mutations associated with Canavan disease are structurally characterized. PMID: 25003821
    3. Definitive evidence is presented to show that the recombinantly-expressed human aspartoacylase is not a glycoprotein. PMID: 24632142
    4. This is the first case report of ASPA mutation studies in Canavan disease from Indian subcontinent. PMID: 22878930
    5. a novel mutation Y88X within the aspartoacylase gene in a consanguineous family with an affected child diagnosed as Canavan disease. PMID: 22468686
    6. Human aspartoacylase gene expression was high not only in brain and kidney, but also in lung and liver. PMID: 22750302
    7. Gene ASPA (NM_000049) was undertaken to sequence for mutation analysis. PMID: 22219087
    8. We report on an Italian female patient with Canavan disease due to a missense mutation of the aspartoacylase gene and a 17p13.3 chromosomal microdeletion PMID: 22019069
    9. the ASPA gene was analysed in 22 unrelated non-Jewish patients with Canavan disease, and 24 different mutations were found PMID: 12638939
    10. Mild-onset presentation of Canavan's disease associated with novel G212A point mutation in aspartoacylase gene PMID: 16437572
    11. molecular weight of the purified enzyme is higher than predicted, suggesting the presence of post-translational modifications. Deglycosylation of aspartoacylase or mutation at glycosylation site causes decreased enzyme stability and catalytic activity PMID: 16669630
    12. a green fluorescent protein-human ASPA fusion protein larger than the permissible size for the nuclear pore complex was enzymatically active and showed mixed nuclear-cytoplasmic distribution. PMID: 16935940
    13. The finding that wild-type and Glu178Asp have the same K(m) but different k(cat) values confirms the idea that the carboxylate group contributes importantly to the enzymatic activity of aspartoacylase. PMID: 17027983
    14. the N-terminal domain of aspartoacylase adopts a protein fold similar to that of zinc-dependent hydrolases related to carboxypeptidases A PMID: 17194761
    15. These results show that aspartoacylase is a member of the caboxypeptidase A family and offer novel explanations for most loss-of-function aspartoacylase mutations associated with Canavan Disease. PMID: 17391648
    16. New structure of human aspartoacylase complexed with a catalytic intermediate analogue, N-phosphonomethyl- l-aspartate, supports a carboxypeptidase-type mechanism for hydrolysis of the amide bond of the substrate, N-acetyl- l-aspartate. PMID: 18293939

    顯示更多

    收起更多

  • 相關疾病:
    Canavan disease (CAND)
  • 亞細胞定位:
    Cytoplasm. Nucleus.
  • 蛋白家族:
    AspA/AstE family, Aspartoacylase subfamily
  • 組織特異性:
    Brain white matter, skeletal muscle, kidney, adrenal glands, lung and liver.
  • 數據庫鏈接:

    HGNC: 756

    OMIM: 271900

    KEGG: hsa:443

    STRING: 9606.ENSP00000263080

    UniGene: Hs.171142



主站蜘蛛池模板: 久久九九久精品国产| 无码高潮爽到爆的喷水视频| 中文字幕在线亚洲精品| 国产精品有码无码av在线播放 | 无码人妻久久一区二区三区不卡| 人与禽交av在线播放| 免费网站看v片在线18禁无码| 美国人性欧美xxxx| 强奷乱码中文字幕熟女一| 亚洲成在人线av无码| 日本亚洲国产一区二区三区| 永久不封国产av毛片| 中文字幕久久熟女人妻av免费| 色偷偷噜噜噜亚洲男人 | 欧美怡红院免费全部视频| 免费无码成人片| 满春阁精品a∨在线观看| 国内精品久久久久影院亚瑟| 天天做天天摸天天爽天天爱| 亚洲国产精品成人精品无码区在线 | 精品国产一区二区三区四区五区| 亚洲综合色婷婷七月丁香| 制服丝袜亚洲中文欧美在线| 亚洲a∨无码男人的天堂| 少妇愉情理伦片高潮日本| 蜜臀色欲av在线播放国产日韩| 亚洲国产精品隔壁老王| 女人爽到高潮免费看视频| 98视频精品全部国产| 亚洲日本乱码中文在线电影| 国产一精品一av一免费| 少妇又紧又色又爽又刺激视频| 亚洲精品无码久久久久yw| 加勒比东京热无码一区| 999国内精品永久免费视频| 久久综合97丁香色香蕉| 野外做受又硬又粗又大视幕| 中文国产成人精品久久不卡| 97se亚洲国产综合自在线尤物| 亚洲欧美中文高清在线专区| 中文亚洲欧美日韩无线码|