在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Aspartate aminotransferase, mitochondrial (GOT2)

In Stock
  • 中文名稱:
    人GOT2重組蛋白
  • 貨號:
    CSB-EP009681HU
  • 規格:
    ¥1536
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產品詳情

  • 純度:
    Greater than 85% as determined by SDS-PAGE.
  • 基因名:
    GOT2
  • Uniprot No.:
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Full Length of Mature Protein
  • 來源:
    E.coli
  • 分子量:
    52.2 kDa
  • 表達區域:
    30-430aa
  • 氨基酸序列
    SSWWTHVEMGPPDPILGVTEAFKRDTNSKKMNLGVGAYRDDNGKPYVLPSVRKAEAQIAAKNLDKEYLPIGGLAEFCKASAELALGENSEVLKSGRFVTVQTISGTGALRIGASFLQRFFKFSRDVFLPKPTWGNHTPIFRDAGMQLQGYRYYDPKTCGFDFTGAVEDISKIPEQSVLLLHACAHNPTGVDPRPEQWKEIATVVKKRNLFAFFDMAYQGFASGDGDKDAWAVRHFIEQGINVCLCQSYAKNMGLYGERVGAFTMVCKDADEAKRVESQLKILIRPMYSNPPLNGARIAAAILNTPDLRKQWLQEVKVMADRIIGMRTQLVSNLKKEGSTHNWQHITDQIGMFCFTGLKPEQVERLIKEFSIYMTKDGRISVAGVTSSNVGYLAHAIHQVTK
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 10xHis-tagged and C-terminal Myc-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    3-7 business days
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). As a member of the malate-aspartate shuttle, it has a key role in the intracellular NAD(H) redox balance. Is important for metabolite exchange between mitochondria and cytosol, and for amino acid metabolism. Facilitates cellular uptake of long-chain free fatty acids.
  • 基因功能參考文獻:
    1. Study utilizing integrative analysis of transcriptomic, metabolomic, and clinical data propose a model of GOT2 transcriptional regulation, in which the cooperative phosphorylation of STAT3 and direct joint binding of STAT3 and p65/NF-kappaB to the proximal GOT2 promoter are important. Furthermore, high aberrant GOT2 expression is prognostic in diffuse large B-cell lymphoma. PMID: 29666362
    2. The results of our study on this larger than 5800-patient cohort suggest beneficial effects of high B12 vitamin level, negative effects of high sodium levels or high AST (aspartate aminotransferase) liver enzyme levels to cognition. PMID: 28918286
    3. Like in adults, FABP seems to be associated with markers of metabolic risk in obese adolescents PMID: 28183455
    4. Data suggest that, in context of abnormal hepatic lipid accumulation in nonalcoholic fatty liver disease, circulating GOT2 rises due to up-regulation of hepatic expression of GOT2 associated with greater gluconeogenesis and insulin resistance. PMID: 26791191
    5. A previously unknown mechanism by which GOT2 acetylation stimulates the malate-aspartate NADH shuttle activity and oxidative protection. PMID: 25755250
    6. High glucose infusion was associated with increased expression of higher plasma membrane-associated fatty acid-binding protein (FABPpm). PMID: 24937540
    7. The lipid binding process in L-FABP is associated with backbone dynamics. PMID: 22713574
    8. Frequency of polymorphism are similar in control groups and schizophrenics. PMID: 17728674

    顯示更多

    收起更多

  • 亞細胞定位:
    Mitochondrion matrix. Cell membrane.
  • 蛋白家族:
    Class-I pyridoxal-phosphate-dependent aminotransferase family
  • 數據庫鏈接:

    HGNC: 4433

    OMIM: 138150

    KEGG: hsa:2806

    STRING: 9606.ENSP00000245206

    UniGene: Hs.599470



主站蜘蛛池模板: 国产福利精品一区二区| 天堂在线www中文| 伊人久久大香线蕉av网站| 国产亚洲精品合集久久久久| 69国产精品成人aaaaa片| 国产性色播播毛片| 国产农村老太xxxxhdxx| 国产乱人伦app精品久久| 亚洲熟妇无码八av在线播放| 午夜亚洲www湿好大| 亚洲乱码av中文一区二区软件| 国产日本精品视频在线观看| 日本三级欧美三级人妇视频 | 无线乱码一二三区免费看| 亚洲人色婷婷成人网站在线观看 | 亚洲成av人片无码bt种子下载| 日韩精品亚洲色大成网站| 综合自拍亚洲综合图区高清| 裸身美女无遮挡永久免费视频| 精品国产精品三级精品av网址| 久久国产主播福利在线| 亚洲国产一区二区精品无码| 无码播放一区二区三区| 99久久精品无码一区二区三区| 国产亚洲色婷婷久久99精品| 亚洲精品国产品国语原创| 中文字幕亚洲综合久久蜜桃| 免费毛片全部不收费的| 成人区精品一区二区婷婷 | 又大又粗又长的高潮视频| 国产精品福利一区二区| 亚洲国产成人久久精品大牛影视| 中文字幕人妻熟女av| 国产下药迷倒白嫩美女网站| 同性男男黄g片免费网站| 欧美高清性色生活片免费观看| 亚洲中文字幕无码卡通动漫野外| 亚洲国产精品尤物yw在线观看| 中国大陆高清aⅴ毛片| 欧洲熟妇色xxxxx视频| 日韩中文亚洲欧美视频二|