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  4. Human glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2) (GOT2) ELISA kit

Human glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2) (GOT2) ELISA kit

  • 中文名稱：
    人谷氨酸谷草轉氨酶2，線粒體（谷草轉氨酶2）(GOT2)酶聯免疫試劑盒
  • 貨號：
    CSB-E17834h
  • 規格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產品詳情

  • 產品描述：
    人谷氨酸谷草轉氨酶2，線粒體（谷草轉氨酶2）(GOT2)酶聯免疫試劑盒（CSB-E17834h）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的GOT2含量。GOT2即谷草轉氨酶 2，是一種參與細胞代謝的關鍵酶。其背景上，與多種生理過程尤其是氨基酸代謝相關。研究機制方面，它在細胞能量代謝、腫瘤發生發展等進程中發揮重要作用，影響腫瘤細胞增殖和轉移，是潛在的疾病治療靶點。試劑盒檢測范圍為0.156 mU/mL-10 mU/mL，可為科研人員探究肝臟疾病模型、代謝通路調控、藥物作用機制等基礎研究提供可靠工具，尤其適用于動物實驗或體外培養細胞中GOT2活性動態變化的定量分析，為揭示線粒體相關分子機制提供技術支持。本品僅用于科研，不用于臨床診斷，產品具體參數及操作步驟詳見產品說明書。
  • 別名：
    AATM_HUMAN ELISA Kit; AL022787 ELISA Kit; Aspartate aminotransferase 2 ELISA Kit; Aspartate aminotransferase ELISA Kit; Aspartate aminotransferase; mitochondrial ELISA Kit; Aspartate transaminase 2 ELISA Kit; ASPATA ELISA Kit; EC 2.6.1.1 ELISA Kit; FABP 1 ELISA Kit; FABP pm ELISA Kit; FABP-1 ELISA Kit; FABPpm ELISA Kit; Fatty acid binding protein ELISA Kit; Fatty acid-binding protein ELISA Kit; FLJ40994 ELISA Kit; Glutamate oxaloacetate transaminase 2 ELISA Kit; Glutamate oxaloacetate transaminase 2; mitochondrial ELISA Kit; Glutamate oxaloacetate transaminase; mitochondrial ELISA Kit; Glutamic oxaloacetic transaminase 2; mitochondrial (aspartate aminotransferase 2) ELISA Kit; Got 2 ELISA Kit; GOT2 ELISA Kit; KAT4 ELISA Kit; KATIV ELISA Kit; kynurenine aminotransferase 4 ELISA Kit; Kynurenine aminotransferase IV ELISA Kit; kynurenine--oxoglutarate transaminase 4 ELISA Kit; kynurenine--oxoglutarate transaminase IV ELISA Kit; mAspAT ELISA Kit; MGC102129 ELISA Kit; MGC115763 ELISA Kit; mitAAT ELISA Kit; mitochondrial ELISA Kit; Mitochondrial aspartate aminotransferase ELISA Kit; OTTMUSP00000017748 ELISA Kit; Plasma membrane fatty acid binding protein ELISA Kit; Plasma membrane-associated fatty acid-binding protein ELISA Kit; Transaminase A ELISA Kit
  • 縮寫：
    GOT2
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測范圍：
    0.156 mU/mL-10 mU/mL
  • 靈敏度：
    0.039 mU/mL
  • 反應時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領域：
    Signal Transduction
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human GOT2 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　 Sample Serum(n=4)
    1:1 Average % 85
    Range % 80-89
    1:2 Average % 92
    Range % 88-97
    1:4 Average % 96
    Range % 91-100
    1:8 Average % 87
    Range % 82-91
  • 回收率：
    The recovery of human GOT2 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample Type Average % Recovery Range
    Serum (n=5) 103 98-109
    EDTA plasma (n=4) 95 90-100
  • 標準曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    mU/ml OD1 OD2 Average Corrected
    10 2.186 2.268 2.227 2.028
    5 1.765 1.794 1.780 1.581
    2.5 1.391 1.380 1.386 1.187
    1.25 0.928 0.911 0.920 0.721
    0.625 0.654 0.623 0.639 0.440
    0.312 0.439 0.459 0.449 0.250
    0.156 0.327 0.341 0.334 0.135
    0 0.202 0.195 0.199 　
  • 數據處理：
  • 貨期：
    3-5 working days

產品評價

靶點詳情

  • 功能：
    Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). As a member of the malate-aspartate shuttle, it has a key role in the intracellular NAD(H) redox balance. Is important for metabolite exchange between mitochondria and cytosol, and for amino acid metabolism. Facilitates cellular uptake of long-chain free fatty acids.
  • 基因功能參考文獻：
    1. Study utilizing integrative analysis of transcriptomic, metabolomic, and clinical data propose a model of GOT2 transcriptional regulation, in which the cooperative phosphorylation of STAT3 and direct joint binding of STAT3 and p65/NF-kappaB to the proximal GOT2 promoter are important. Furthermore, high aberrant GOT2 expression is prognostic in diffuse large B-cell lymphoma. PMID: 29666362
    2. The results of our study on this larger than 5800-patient cohort suggest beneficial effects of high B12 vitamin level, negative effects of high sodium levels or high AST (aspartate aminotransferase) liver enzyme levels to cognition. PMID: 28918286
    3. Like in adults, FABP seems to be associated with markers of metabolic risk in obese adolescents PMID: 28183455
    4. Data suggest that, in context of abnormal hepatic lipid accumulation in nonalcoholic fatty liver disease, circulating GOT2 rises due to up-regulation of hepatic expression of GOT2 associated with greater gluconeogenesis and insulin resistance. PMID: 26791191
    5. A previously unknown mechanism by which GOT2 acetylation stimulates the malate-aspartate NADH shuttle activity and oxidative protection. PMID: 25755250
    6. High glucose infusion was associated with increased expression of higher plasma membrane-associated fatty acid-binding protein (FABPpm). PMID: 24937540
    7. The lipid binding process in L-FABP is associated with backbone dynamics. PMID: 22713574
    8. Frequency of polymorphism are similar in control groups and schizophrenics. PMID: 17728674

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  • 亞細胞定位：
    Mitochondrion matrix. Cell membrane.
  • 蛋白家族：
    Class-I pyridoxal-phosphate-dependent aminotransferase family
  • 數據庫鏈接：

    HGNC: 4433

    OMIM: 138150

    KEGG: hsa:2806

    STRING: 9606.ENSP00000245206

    UniGene: Hs.599470



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