在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Asialoglycoprotein receptor 1 (ASGR1), partial

Recombinant Human Asialoglycoprotein receptor 1 (ASGR1), partial

  • 中文名稱：
    Recombinant Human Asialoglycoprotein receptor 1(ASGR1),partial
  • 貨號：
    CSB-YP002207HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human Asialoglycoprotein receptor 1(ASGR1),partial
  • 貨號：
    CSB-EP002207HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human Asialoglycoprotein receptor 1(ASGR1),partial
  • 貨號：
    CSB-BP002207HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human Asialoglycoprotein receptor 1(ASGR1),partial
  • 貨號：
    CSB-MP002207HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    ASGP-R 1; ASGPR 1; ASGPR; ASGPR1; Asgr1; ASGR1_HUMAN; Asialoglycoprotein receptor 1; C type lectin domain family 4 member H1; C-type lectin domain family 4 member H1; CLEC4H1; Hepatic lectin H1; HL-1
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface.
  • 基因功能參考文獻：
    1. Authors report the generation of a human embryonic stem cell line WAe001-A-6 harbouring homozygous ASGR1 mutations using CRISPR/Cas9. The mutation involves a 37bp deletion, resulting in a frame shift. PMID: 28952928
    2. PEGylated lipoplexes were well tolerated by both HEK293 (ASGP-R-negative) and HepG2 (ASGP-R-positive) cell lines and delivered DNA to the hepatoma cell line HepG2 by ASGP-R mediation at levels three-fold greater than nonPEGylated lipoplexes. PMID: 28063265
    3. findings show that the hepatitis E virus (HEV) ORF2 protein interacts directly with the ectodomain of both ASGR1 and ASGR2; ASGPR is involved in and facilitates HEV infection by binding to ORF2 PMID: 27155063
    4. ASGR1 can inhibit the activity of V-ATPase by interacting with LASS2, thereby suppressing the metastatic potential of hepatoma cells. PMID: 27241665
    5. This review will focus on the mechanisms of platelet senescence with specific emphasis on the role of post-translational modifications in platelet life-span and thrombopoietin production downstream of the hepatic Ashwell-Morrell receptor, originally termed asialoglycoprotein receptor (ASGPR). PMID: 27207430
    6. ASGR1 haploinsufficiency was associated with reduced levels of non-HDL cholesterol and a reduced risk of coronary artery disease. PMID: 27192541
    7. Flow cytometric assessment of ASGPR expression may be a useful predictor of liver dysfunction following major hepatectomy for HCC in Chinese patients. PMID: 25404440
    8. Anti-ASGPR antibody could be used for specific and efficient HCC CTC enrichment, and anti-P-CK combined with anti-CPS1 antibodies is superior to identification with one antibody alone in the sensitivity for HCC CTC detection. PMID: 24763545
    9. Endocytic AMR controls TPO expression through Janus kinase 2 (JAK2) and the acute phase response signal transducer and activator of transcription 3 (STAT3) in vivo and in vitro PMID: 25485912
    10. Anti-ASGPR levels correlate with biochemical parameters and with the severity and manifestation autoimmune processes in patients with autoimmune hepatitis. PMID: 24933948
    11. The examined ASGPR1 expression levels by immunohistochemistry in HCC with different grades. Guidance for a targeting delivery strategy for anti-cancer drugs to HCC is suggested in this report. PMID: 23979840
    12. the distribution of ASGR in human testis, was investigated. PMID: 23604802
    13. the cooperative binding mode of Ca(2+) makes it possible for ASGP-R to be more sensitive to Ca(2+) concentrations in early endosomes, and plays an important role in the efficient release of ligand from ASGP-R PMID: 22613667
    14. Constant sH2a levels suggest constitutive secretion from hepatocytes in healthy individuals; therefore, a decrease with cirrhosis suggests a diagnostic potential. PMID: 22219600
    15. found that the asialoglycoprotein receptor (ASGPR) is involved in hepatocyte recognition of cells predestined for killing, including activated autologous T lymphocytes PMID: 21656538
    16. Asialoglycoprotein receptor (ASGPR) interacted specifically and directly with the preS1 domain of HBV in vivo and in vitro. PMID: 21207081
    17. Two naturally occurring ASGPR1 splice variants are produced in human hepatocytes. PMID: 20886072
    18. our findings suggest that both fibronectin and ASGPR mediate HBsAg binding to the cell surface, which provides further evidence for the potential roles of these two proteins in mediating HBV binding to liver cells. PMID: 20364278
    19. The minor subunit splice variants, H2b and H2c, of the human asialoglycoprotein receptor are present with the major subunit H1 in different hetero-oligomeric receptor complexes PMID: 11943787
    20. primary renal proximal tubular epithelial cells have a functional ASGPR, consisting of the H1 and H2 subunits, that is capable of specific ligand binding and uptake PMID: 12119473
    21. Phosphorylation-dependent interaction with molecular chaperones PMID: 12167617
    22. the effects of palmitoylation on ASGP-R activity and function PMID: 12359251
    23. the spacing of a Cys residue relative to the TMD in the primary protein sequence of H1 is the major determinant for successful palmitoylation PMID: 12370180
    24. Exposure of beta-galactose results in the rapid clearance of platelets from the circulation by asialoglycoprotein receptor-expressing liver macrophages and hepatocytes. PMID: 19520807

    顯示更多

    收起更多

  • 亞細胞定位：
    [Isoform H1a]: Membrane; Single-pass type II membrane protein.; [Isoform H1b]: Secreted.
  • 組織特異性：
    Expressed exclusively in hepatic parenchymal cells.
  • 數據庫鏈接：

    HGNC: 742

    OMIM: 108360

    KEGG: hsa:432

    STRING: 9606.ENSP00000269299

    UniGene: Hs.12056



主站蜘蛛池模板： 蜜桃传媒av免费观看麻豆| 久久久综合香蕉尹人综合网 | 精品国产经典三级在线看| 最新69成人精品视频免费 | 狠狠色狠狠色综合| 日韩国产丝袜人妻一二区| 欧美兽交xxxx×视频| 东京热人妻丝袜无码av一二三区观| 日本免费一区二区三区视频观看 | 四虎永久在线精品免费网站 | 四虎一区二区成人免费影院网址| 97se狼狼狼狼狼亚洲网| 精品一区二区三区自拍图片区| 国产精品极品美女自在线观看免费| 无码av最新无码av专区| 精品久久久久久亚洲中文字幕| 青青草免费公开视频| 妺妺窝人体色www聚色窝仙踪| 久久香蕉国产线看观看手机| av人摸人人人澡人人超碰手机版 | 久久人人爽人人爽人人片av高请| 日韩欧无码一二三区免费不卡| 99久久99视频只有精品| 国产精欧美一区二区三区| 男人边做边吃奶头视频| 开心色婷婷色五月激情| 欧美搡bbbbb搡bbbbb| 69久久精品无码一区二区| 色 成人 亚洲| 人妻av乱片av出轨av| 人妻激情偷乱视频一区二区三区| 亚洲影院天堂中文av色| 波多野结衣av高清一区二区三区 | 亚洲丰满熟妇在线播放电影全集| 亚洲 成人 无码 在线观看| 天堂资源中文最新版在线一区| 女上男下啪啪激烈高潮无遮盖 | 免免费国产aaaaa片| 丰满人妻熟妇乱又伦精品视| 无码综合天天久久综合网| 欧美成人午夜免费影院手机在线看 |