在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

ASGR1 Antibody, FITC conjugated

  • 中文名稱:
    ASGR1兔多克隆抗體, FITC偶聯(lián)
  • 貨號:
    CSB-PA17469C0Rb
  • 規(guī)格:
    ¥880
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) ASGR1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    ASGP-R 1 antibody; ASGPR 1 antibody; ASGPR antibody; ASGPR1 antibody; Asgr1 antibody; ASGR1_HUMAN antibody; Asialoglycoprotein receptor 1 antibody; C type lectin domain family 4 member H1 antibody; C-type lectin domain family 4 member H1 antibody; CLEC4H1 antibody; Hepatic lectin H1 antibody; HL-1 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Asialoglycoprotein receptor 1 protein (68-291AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface.
  • 基因功能參考文獻:
    1. Authors report the generation of a human embryonic stem cell line WAe001-A-6 harbouring homozygous ASGR1 mutations using CRISPR/Cas9. The mutation involves a 37bp deletion, resulting in a frame shift. PMID: 28952928
    2. PEGylated lipoplexes were well tolerated by both HEK293 (ASGP-R-negative) and HepG2 (ASGP-R-positive) cell lines and delivered DNA to the hepatoma cell line HepG2 by ASGP-R mediation at levels three-fold greater than nonPEGylated lipoplexes. PMID: 28063265
    3. findings show that the hepatitis E virus (HEV) ORF2 protein interacts directly with the ectodomain of both ASGR1 and ASGR2; ASGPR is involved in and facilitates HEV infection by binding to ORF2 PMID: 27155063
    4. ASGR1 can inhibit the activity of V-ATPase by interacting with LASS2, thereby suppressing the metastatic potential of hepatoma cells. PMID: 27241665
    5. This review will focus on the mechanisms of platelet senescence with specific emphasis on the role of post-translational modifications in platelet life-span and thrombopoietin production downstream of the hepatic Ashwell-Morrell receptor, originally termed asialoglycoprotein receptor (ASGPR). PMID: 27207430
    6. ASGR1 haploinsufficiency was associated with reduced levels of non-HDL cholesterol and a reduced risk of coronary artery disease. PMID: 27192541
    7. Flow cytometric assessment of ASGPR expression may be a useful predictor of liver dysfunction following major hepatectomy for HCC in Chinese patients. PMID: 25404440
    8. Anti-ASGPR antibody could be used for specific and efficient HCC CTC enrichment, and anti-P-CK combined with anti-CPS1 antibodies is superior to identification with one antibody alone in the sensitivity for HCC CTC detection. PMID: 24763545
    9. Endocytic AMR controls TPO expression through Janus kinase 2 (JAK2) and the acute phase response signal transducer and activator of transcription 3 (STAT3) in vivo and in vitro PMID: 25485912
    10. Anti-ASGPR levels correlate with biochemical parameters and with the severity and manifestation autoimmune processes in patients with autoimmune hepatitis. PMID: 24933948
    11. The examined ASGPR1 expression levels by immunohistochemistry in HCC with different grades. Guidance for a targeting delivery strategy for anti-cancer drugs to HCC is suggested in this report. PMID: 23979840
    12. the distribution of ASGR in human testis, was investigated. PMID: 23604802
    13. the cooperative binding mode of Ca(2+) makes it possible for ASGP-R to be more sensitive to Ca(2+) concentrations in early endosomes, and plays an important role in the efficient release of ligand from ASGP-R PMID: 22613667
    14. Constant sH2a levels suggest constitutive secretion from hepatocytes in healthy individuals; therefore, a decrease with cirrhosis suggests a diagnostic potential. PMID: 22219600
    15. found that the asialoglycoprotein receptor (ASGPR) is involved in hepatocyte recognition of cells predestined for killing, including activated autologous T lymphocytes PMID: 21656538
    16. Asialoglycoprotein receptor (ASGPR) interacted specifically and directly with the preS1 domain of HBV in vivo and in vitro. PMID: 21207081
    17. Two naturally occurring ASGPR1 splice variants are produced in human hepatocytes. PMID: 20886072
    18. our findings suggest that both fibronectin and ASGPR mediate HBsAg binding to the cell surface, which provides further evidence for the potential roles of these two proteins in mediating HBV binding to liver cells. PMID: 20364278
    19. The minor subunit splice variants, H2b and H2c, of the human asialoglycoprotein receptor are present with the major subunit H1 in different hetero-oligomeric receptor complexes PMID: 11943787
    20. primary renal proximal tubular epithelial cells have a functional ASGPR, consisting of the H1 and H2 subunits, that is capable of specific ligand binding and uptake PMID: 12119473
    21. Phosphorylation-dependent interaction with molecular chaperones PMID: 12167617
    22. the effects of palmitoylation on ASGP-R activity and function PMID: 12359251
    23. the spacing of a Cys residue relative to the TMD in the primary protein sequence of H1 is the major determinant for successful palmitoylation PMID: 12370180
    24. Exposure of beta-galactose results in the rapid clearance of platelets from the circulation by asialoglycoprotein receptor-expressing liver macrophages and hepatocytes. PMID: 19520807

    顯示更多

    收起更多

  • 亞細胞定位:
    [Isoform H1a]: Membrane; Single-pass type II membrane protein.; [Isoform H1b]: Secreted.
  • 組織特異性:
    Expressed exclusively in hepatic parenchymal cells.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 742

    OMIM: 108360

    KEGG: hsa:432

    STRING: 9606.ENSP00000269299

    UniGene: Hs.12056



主站蜘蛛池模板: 久久久精品2020免费观看| 久久人人爽人人爽人人片av不 | 免费精品国产人妻国语| 欧美色欧美亚洲另类二区| 无码精品国产dvd在线观看9久| 亚洲国产激情一区二区三区| 日本老熟妇乱子伦视频| 超清无码波多野吉衣中文| 国产一线二线三线女| 亚洲人成网站在线播放2019| 亚洲免费综合色在线视频| 色屁屁www影院免费观看 | 亚洲国产色播av在线| 夫妇交换性三中文字幕| 在线日韩日本国产亚洲| 欧洲精品一卡2卡三卡4卡影视| 久9热视频这里只精品18| 国产一精品一av一免费| 精品国产午夜肉伦伦影院| 久久九九有精品国产23百花影院| 男女免费观看在线爽爽爽视频| 精品国精品国产自在久国产应用| 国产大屁股视频免费区| 欧美精品1卡二卡三卡四卡| 99精品国产综合久久久久五月天| 亚洲乱码国产一区三区| 日韩av无码国产精品| 乱人伦视频中文字幕| 免费国产黄线在线观看| 青青草国产成人99久久| 国产99视频精品免视看9| 亚洲 一区二区 在线| 亚洲国产欧美在线人成app| 精品国产美女福到在线不卡| 亚洲在av人极品无码| 爆乳喷奶水无码正在播放 | 亚洲欧美日韩国产成人精品影院 | 少妇高潮毛片色欲ava片| 亚洲欧美日韩视频高清专区| 日韩精品 中文字幕 视频在线| 亚洲精品无码永久在线观看性色|