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  4. Recombinant Human Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 (ARAP3), partial

Recombinant Human Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 (ARAP3), partial

  • 中文名稱：
    Recombinant Human Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3(ARAP3) ,partial
  • 貨號：
    CSB-YP819904HU
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3(ARAP3) ,partial
  • 貨號：
    CSB-EP819904HU
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3(ARAP3) ,partial
  • 貨號：
    CSB-EP819904HU-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3(ARAP3) ,partial
  • 貨號：
    CSB-BP819904HU
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3(ARAP3) ,partial
  • 貨號：
    CSB-MP819904HU
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    ARAP3; CENTD3; Arf-GAP with Rho-GAP domain; ANK repeat and PH domain-containing protein 3; Centaurin-delta-3; Cnt-d3
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Acts on ARF6, RAC1, RHOA and CDC42. Plays a role in the internalization of anthrax toxin.
  • 基因功能參考文獻：
    1. Structural Basis for the Specific Recognition of RhoA by the Dual GTPase-activating Protein ARAP3. PMID: 27311713
    2. structural and binding affinity between odin and arap3 PMID: 23239578
    3. Phosphoinositide 3-OH kinase (PI3K) is input into the regulation of beta2 integrin activity, and processes dependent on its responses, by signaling through its effector ARAP3. PMID: 23180820
    4. The structural basis for the interaction between Arap3 and Vav2, hydrophobic pockets and binding specificity. PMID: 22750419
    5. ARAP3 is a unique Src substrate that suppresses peritoneal dissemination of scirrhous gastric carcinoma cells. PMID: 21076469
    6. None of the individual PH domains can bind to PtdIns(3,4,5)P3; rather, a fragment comprising two PH domains and an N-terminal linker is minimally required for binding. PMID: 19786092
    7. The catalytic domain of ARF-GAP alone is sufficient to initiate uncoating of liposome-derived COPI-coated vesicles. ARF-GAP activity is not required for COPI coat assembly & does not seem to be an essential coat component of COPI vesicles. PMID: 12832619
    8. ARAP3 has a role in integrin-mediated tyrosine kinase signalling pathways controlling Rho GTPases and cell spreading PMID: 15546919
    9. ARAP3 deficiency produced by antisense expression of an ARAP3 EST impaired entry of anthrax PA and its bound toxigenic moieties into both human and mouse cells, resulting in reduced toxin sensitivity PMID: 15569923
    10. In a yeast two-hybrid screen for new interaction partners of Arap3, the PI 5'-phosphatase SHIP2 was identified as an interaction partner of Arap3. PMID: 17314030

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  • 亞細胞定位：
    Cytoplasm. Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein. Cell projection, lamellipodium. Cell projection, ruffle.
  • 數據庫鏈接：

    HGNC: 24097

    OMIM: 606647

    KEGG: hsa:64411

    STRING: 9606.ENSP00000239440

    UniGene: Hs.726187



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