在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Arachidonate 12-lipoxygenase, 12R-type (ALOX12B)

Recombinant Human Arachidonate 12-lipoxygenase, 12R-type (ALOX12B)

  • 中文名稱：
    Recombinant Human Arachidonate 12-lipoxygenase, 12R-type(ALOX12B)
  • 貨號：
    CSB-YP001618HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human Arachidonate 12-lipoxygenase, 12R-type(ALOX12B)
  • 貨號：
    CSB-EP001618HU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human Arachidonate 12-lipoxygenase, 12R-type(ALOX12B)
  • 貨號：
    CSB-EP001618HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human Arachidonate 12-lipoxygenase, 12R-type(ALOX12B)
  • 貨號：
    CSB-BP001618HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human Arachidonate 12-lipoxygenase, 12R-type(ALOX12B)
  • 貨號：
    CSB-MP001618HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    ALOX12B
  • Uniprot No.：
  • 別名：
    ALOX12B; Arachidonate 12-lipoxygenase; 12R-type; 12R-LOX; 12R-lipoxygenase; EC 1.13.11.-; Epidermis-type lipoxygenase 12
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Full length protein
  • 表達區(qū)域：
    1-701
  • 氨基酸序列
    MATYKVRVAT GTDLLSGTRD SISLTIVGTQ GESHKQLLNH FGRDFATGAV GQYTVQCPQD LGELIIIRLH KERYAFFPKD PWYCNYVQIC APNGRIYHFP AYQWMDGYET LALREATGKT TADDSLPVLL EHRKEEIRAK QDFYHWRVFL PGLPSYVHIP SYRPPVRRHR NPNRPEWNGY IPGFPILINF KATKFLNLNL RYSFLKTASF FVRLGPMALA FKVRGLLDCK HSWKRLKDIR KIFPGKKSVV SEYVAEHWAE DTFFGYQYLN GVNPGLIRRC TRIPDKFPVT DDMVAPFLGE GTCLQAELEK GNIYLADYRI MEGIPTVELS GRKQHHCAPL CLLHFGPEGK MMPIAIQLSQ TPGPDCPIFL PSDSEWDWLL AKTWVRYAEF YSHEAIAHLL ETHLIAEAFC LALLRNLPMC HPLYKLLIPH TRYTVQINSI GRAVLLNEGG LSAKGMSLGV EGFAGVMVRA LSELTYDSLY LPNDFVERGV QDLPGYYYRD DSLAVWNALE KYVTEIITYY YPSDAAVEGD PELQSWVQEI FKECLLGRES SGFPRCLRTV PELIRYVTIV IYTCSAKHAA VNTGQMEFTA WMPNFPASMR NPPIQTKGLT TLETFMDTLP DVKTTCITLL VLWTLSREPD DRRPLGHFPD IHFVEEAPRR SIEAFRQRLN QISHDIRQRN KCLPIPYYYL DPVLIENSIS I
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

相關(guān)產(chǎn)品

靶點詳情

  • 功能：
    Catalyzes the regio and stereo-specific incorporation of a single molecule of dioxygen into free and esterified polyunsaturated fatty acids generating lipid hydroperoxides that can be further reduced to the corresponding hydroxy species. In the skin, acts upstream of ALOXE3 on the lineolate moiety of esterified omega-hydroxyacyl-sphingosine (EOS) ceramides to produce an epoxy-ketone derivative, a crucial step in the conjugation of omega-hydroxyceramide to membrane proteins. Therefore plays a crucial role in the synthesis of corneocytes lipid envelope and the establishment of the skin barrier to water loss. May also play a role in the regulation of the expression of airway mucins.
  • 基因功能參考文獻：
    1. The rare homozygous ALOX12B mutation found in Patient 5 causes a change in a conserved residue; Leu315 into a proline in the catalytic domain of 12R-LOX. PMID: 28236338
    2. report adds information on the clinical picture of autosomal recessive congenital ichthyosis caused by ALOX12B mutations PMID: 26575587
    3. We found that the contribution of the ALOX12B gene to the pathogenesis of Autosomal Recessive Congenital Ichthyosis to be as important as that of TGM1 in families of Arab Muslim origin PMID: 23621129
    4. Loss-of-function mutations in the LOX genes ALOX12B and ALOXE3 have been found to represent the second most common cause of autosomal recessive congenital ichthyosis. [review] PMID: 23954555
    5. This review covers the background to discovery of the two key lipoxygenases (LOX) involved in epidermal barrier function, 12R-LOX and eLOX3. [review] PMID: 24021977
    6. Autosomal recessive congenital ichthyosis patients with NIPAL4 mutations and abnormal ichthyin expression showed increased 12R-LOX and eLOX-3 staining and a colocalization signal of these LOXs that was three times the normal intensity. PMID: 22622417
    7. It was shown that 12R-lipoxygenase is involved in MUC5AC expression via ERK- and Sp1-signalling pathways. PMID: 22441738
    8. co-overproduction of the two chaperones with 12R-LOX resulted in increased solubility of 12R-LOX and allowed the purification of milligram amounts of active enzyme for structural studies by X-ray diffraction PMID: 21821891
    9. ALOX12B mutations are the leading cause of self-improving collodion ichthyosis in Scandinavia, followed by ALOXE3 mutations, and TGM1 mutations PMID: 19890349
    10. 12-R-LOX and COX-2 play critical roles in the regulation of growth in epidermoid carcinoma PMID: 19558494
    11. Lipoxygenase-3 (ALOXE3) and 12(R)-lipoxygenase (ALOX12B) are mutated in non-bullous congenital ichthyosiform erythroderma (NCIE) linked to chromosome 17p13.1. PMID: 11773004
    12. 12R-LOX hydrolase functions in the normal process of skin differentiation, and that the loss of function mutations are the basis of the LOX-dependent form of Non-bullous congenital ichthyosiform erythroderma. PMID: 15629692
    13. Our data contribute to an enlargement of the spectrum of mutations for the development of efficient molecular genetic tests for analysis of at risk individuals whose carrier status is unknown. PMID: 17139268
    14. Formation of a ligand for the nuclear receptor PPARalpha may be one possibility by which 12R-LOX and eLOX3 contribute to epidermal differentiation. PMID: 17436029
    15. clinical & molecular features of 2 cases of self-healing collodion phenotype that developed mild ichthyosiform erythroderma; both patients were compound heterozygous for novel ALOX12B mutations PMID: 18347291
    16. mutation hotspots in ALOXE3 and allelic heterogeneity in ALOX12B may have roles in autosomal recessive congenital ichthyosis PMID: 19131948

    顯示更多

    收起更多

  • 相關(guān)疾?。?/div>
    Ichthyosis, congenital, autosomal recessive 2 (ARCI2)
  • 亞細胞定位：
    Cytoplasm. Cytoplasm, perinuclear region.
  • 蛋白家族：
    Lipoxygenase family
  • 組織特異性：
    Expressed in B-cells, hair follicles, foreskin keratinocytes and adult skin. Also expressed in psoriatic tissue.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 430

    OMIM: 242100

    KEGG: hsa:242

    STRING: 9606.ENSP00000315167

    UniGene: Hs.136574



主站蜘蛛池模板： 亚洲一区二区三区波多野结衣| 香港三级韩国三级日本三级| 国产精品亚洲片夜色在线| 中国xxxx做受视频| 亚洲v国产v天堂a无码二区| 在线观看无码av免费不卡软件| 色老板精品视频在线观看| 人妻被按摩师玩弄到潮喷| 极品少妇扒开粉嫩小泬视频| 伊人久久大香线蕉无码不卡| аⅴ资源中文在线天堂| 国产真实伦对白全集| 美女粉嫩饱满的一线天mp4| 又黄又爽的60分钟视频| 色婷婷一区二区三区四区成人网 | 国产精品va在线观看无码不卡 | 久久精品国产福利一区二区| 美女被啪到深处抽搐视频| 久久久久蜜桃精品成人片公司| 久久aaaa片一区二区| 亚洲乱亚洲乱妇中文影视| 无码三级av电影在线观看| 丰满熟妇乱子伦| 欧美成人精品三级网站| 在线人人车操人人看视频| 精品四虎国产在免费观看| 粉嫩小泬无遮挡久久久久久 | 久久99精品九九九久久婷婷| 国产精品久久国产三级国| 国内精品久久久久精免费| 免费网站内射红桃视频| 国产欧美日韩综合精品一区二区| 海角社区在线视频播放观看 | 东京热久久综合久久88| 久久久久久毛片免费播放| 中文字幕人妻被公上司喝醉 | 国产熟女内射oooo| 亚洲国产日韩欧美一区二区三区| 亚洲中文欧美在线视频 | 无码一区二区三区av免费蜜桃| 精品综合久久久久久98|