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  4. Recombinant Human Apoptotic chromatin condensation inducer in the nucleus (ACIN1), partial

Recombinant Human Apoptotic chromatin condensation inducer in the nucleus (ACIN1), partial

  • 中文名稱：
    Recombinant Human Apoptotic chromatin condensation inducer in the nucleus(ACIN1) ,partial
  • 貨號：
    CSB-YP890923HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human Apoptotic chromatin condensation inducer in the nucleus(ACIN1) ,partial
  • 貨號：
    CSB-EP890923HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human Apoptotic chromatin condensation inducer in the nucleus(ACIN1) ,partial
  • 貨號：
    CSB-EP890923HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human Apoptotic chromatin condensation inducer in the nucleus(ACIN1) ,partial
  • 貨號：
    CSB-BP890923HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human Apoptotic chromatin condensation inducer in the nucleus(ACIN1) ,partial
  • 貨號：
    CSB-MP890923HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    ACIN1
  • Uniprot No.：
  • 別名：
    ACIN 1; ACIN1; ACINU_HUMAN; Acinus; ACN; Apoptotic chromatin condensation inducer 1; Apoptotic chromatin condensation inducer in the nucleus; DKFZp667N107; fSAP152; functional spliceosome-associated protein 152; KIAA0670
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets; ACIN1 confers RNA-binding to the complex. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells.
  • 基因功能參考文獻：
    1. ACIN1 mRNA was highly expressed in platelets of lung cancer patients PMID: 30201066
    2. We conclude that RNPS1 is a key factor for the quality control of mRNAs that is essential for the phenotypes including cell division. PMID: 29366779
    3. Genome-wide identification of RNA targets of Acinus revealed its role in splicing regulation as well as its involvement in other cellular pathways, including cell cycle progression. PMID: 27365209
    4. acinus L was identified as a potential novel mTORC1 target. PMID: 25907765
    5. Differences in the nuclear localization of Acinus-S' and Acinus-L may suggest that these two isoforms have different functional roles. PMID: 25079509
    6. the ligand-dependent splicing activity of Acinus is related to the retinoic acid-activated retinoic acid receptor PMID: 25205379
    7. An electronegative region on acinusS restricts SRPK2 phosphorylation to a single specific site. PMID: 24444330
    8. Chronic low-dose radiation increases the levels of AKT and acinus proteins via NF-kappaB activation PMID: 23205493
    9. Akt phosphorylation of acinus on serine 422 and 573 results in its resistance to caspase cleavage in the nucleus and the inhibition of acinus-dependent chromatin condensation. PMID: 16177823
    10. Acinus is not involved in DNA condensation but rather has a role in internucleosomal DNA cleavage during programmed cell death PMID: 16537548
    11. We found hypermethylation of the ACIN1 gene in early stage lung adenocarcinoma. The role of methylation status in the development and malignant transformation of lung adenocarcinoma requires clarification. PMID: 17409846
    12. identify Acinus-S' as a novel RAR-interacting protein[Acinus-S'] PMID: 18250153
    13. The authors report here that AAC-11, a survival protein whose expression prevents apoptosis that occurs on deprivation of growth factors, physiologically binds to Acinus and prevents Acinus-mediated DNA fragmentation. PMID: 19387494
    14. A critical role for AKT activation in protecting cells from ionizing radiation-induced apoptosis and the regulation of acinus gene expression is reported. PMID: 19615784
    15. Study shows that transcription corepressor CtBP2 directly binds acinus, which is regulated by nerve growth factor (NGF), inhibiting its stimulatory effect on cyclin A1, but not cyclin A2, expression in leukemia. PMID: 19668232

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  • 亞細胞定位：
    Nucleus. Nucleus speckle. Nucleus, nucleoplasm. Note=Phosphorylation on Ser-1180 by SRPK2 redistributes it from the nuclear speckles to the nucleoplasm.
  • 組織特異性：
    Ubiquitous. The Ser-1180 phosphorylated form (by SRPK2) is highly expressed and phosphorylated in patients with myeloid hematologic malignancies.
  • 數據庫鏈接：

    HGNC: 17066

    OMIM: 604562

    KEGG: hsa:22985

    STRING: 9606.ENSP00000262710

    UniGene: Hs.124490



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