在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. ACIN1 Antibody

ACIN1 Antibody

  • 中文名稱：
    ACIN1兔多克隆抗體
  • 貨號：
    CSB-PA964463
  • 規格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using CSB-PA964463(ACIN1 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA964463(ACIN1 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: K562 cells, 231 cells, Primary antibody: CSB-PA964463(ACIN1 Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    ACIN1
  • 別名：
    ACIN 1 antibody; ACIN1 antibody; ACINU_HUMAN antibody; Acinus antibody; ACN antibody; Apoptotic chromatin condensation inducer 1 antibody; Apoptotic chromatin condensation inducer in the nucleus antibody; DKFZp667N107 antibody; fSAP152 antibody; functional spliceosome-associated protein 152 antibody; KIAA0670 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse
  • 免疫原：
    Synthetic peptide of Human ACIN1
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    WB 1:200-1:1000
    IHC 1:25-1:100
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets; ACIN1 confers RNA-binding to the complex. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells.
  • 基因功能參考文獻：
    1. ACIN1 mRNA was highly expressed in platelets of lung cancer patients PMID: 30201066
    2. We conclude that RNPS1 is a key factor for the quality control of mRNAs that is essential for the phenotypes including cell division. PMID: 29366779
    3. Genome-wide identification of RNA targets of Acinus revealed its role in splicing regulation as well as its involvement in other cellular pathways, including cell cycle progression. PMID: 27365209
    4. acinus L was identified as a potential novel mTORC1 target. PMID: 25907765
    5. Differences in the nuclear localization of Acinus-S' and Acinus-L may suggest that these two isoforms have different functional roles. PMID: 25079509
    6. the ligand-dependent splicing activity of Acinus is related to the retinoic acid-activated retinoic acid receptor PMID: 25205379
    7. An electronegative region on acinusS restricts SRPK2 phosphorylation to a single specific site. PMID: 24444330
    8. Chronic low-dose radiation increases the levels of AKT and acinus proteins via NF-kappaB activation PMID: 23205493
    9. Akt phosphorylation of acinus on serine 422 and 573 results in its resistance to caspase cleavage in the nucleus and the inhibition of acinus-dependent chromatin condensation. PMID: 16177823
    10. Acinus is not involved in DNA condensation but rather has a role in internucleosomal DNA cleavage during programmed cell death PMID: 16537548
    11. We found hypermethylation of the ACIN1 gene in early stage lung adenocarcinoma. The role of methylation status in the development and malignant transformation of lung adenocarcinoma requires clarification. PMID: 17409846
    12. identify Acinus-S' as a novel RAR-interacting protein[Acinus-S'] PMID: 18250153
    13. The authors report here that AAC-11, a survival protein whose expression prevents apoptosis that occurs on deprivation of growth factors, physiologically binds to Acinus and prevents Acinus-mediated DNA fragmentation. PMID: 19387494
    14. A critical role for AKT activation in protecting cells from ionizing radiation-induced apoptosis and the regulation of acinus gene expression is reported. PMID: 19615784
    15. Study shows that transcription corepressor CtBP2 directly binds acinus, which is regulated by nerve growth factor (NGF), inhibiting its stimulatory effect on cyclin A1, but not cyclin A2, expression in leukemia. PMID: 19668232

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus. Nucleus speckle. Nucleus, nucleoplasm. Note=Phosphorylation on Ser-1180 by SRPK2 redistributes it from the nuclear speckles to the nucleoplasm.
  • 組織特異性：
    Ubiquitous. The Ser-1180 phosphorylated form (by SRPK2) is highly expressed and phosphorylated in patients with myeloid hematologic malignancies.
  • 數據庫鏈接：

    HGNC: 17066

    OMIM: 604562

    KEGG: hsa:22985

    STRING: 9606.ENSP00000262710

    UniGene: Hs.124490



主站蜘蛛池模板： 法国伦理少妇愉情| 亚洲精品一线二线三线区别大吗| 日韩人妻无码精品一专区| 中文字幕在线精品视频入口一区 | 少妇被粗大的猛烈进出动视频| 无码高潮少妇毛多水多水| 亚洲aⅴ天堂av天堂无码麻豆| 婷婷色中文字幕综合在线| 亚洲欧美日本中文字不卡| 久久久中日ab精品综合| 强开小婷嫩苞又嫩又紧视频| 成人网站免费大全日韩国产| 欧美性生交活xxxxxdddd| 无码国产一区二区免费| 99视频偷窥在线精品国自产拍| 不卡无码av一区二区三区| 999久久久无码国产精品| 在线视频观看免费视频18| 天天色影网| 日韩精品无码免费一区二区三区| 秋霞午夜一区二区三区黄瓜视频| 国产成人精品无码播放| 好紧好爽好湿别拔出来视频男男| 吃奶摸下高潮60分钟免费视频| 中文字字幕在线成人av电影| 在线视频免费观看爽爽爽| 香蕉欧美成人精品a∨在线观看 | 日韩不卡1卡2卡三卡网站| 黑人巨茎美女高潮视频| 久久国产成人免费网站| 亚洲欧美不卡高清在线观看| 日本特黄特色aaa大片免费| 色欲av永久无码精品无码蜜桃| 永久黄网站免费视频性色| 国产成人精品一区二区秒播| 少妇仑乱a毛片| 国产婷婷成人久久av免费高清| 国产亚洲熟妇在线视频| 人妻熟女一区二区三区app下载| 国产av无码专区国产乱码| 麻豆视传媒精品av|