在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Alpha-N-acetylglucosaminidase (NAGLU)

Recombinant Human Alpha-N-acetylglucosaminidase (NAGLU)

  • 中文名稱：
    人NAGLU重組蛋白
  • 貨號：
    CSB-YP015416HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人NAGLU重組蛋白
  • 貨號：
    CSB-EP015416HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人NAGLU重組蛋白
  • 貨號：
    CSB-EP015416HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人NAGLU重組蛋白
  • 貨號：
    CSB-BP015416HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人NAGLU重組蛋白
  • 貨號：
    CSB-MP015416HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    NAGLU
  • Uniprot No.：
  • 別名：
    Alpha N acetylglucosaminidase; alpha N acetylglucosaminidase; lysosomal; Alpha-N-acetylglucosaminidase 77 kDa form; ANAG; ANAG_HUMAN; CMT2V; MPS IIIB; MPS3B; N acetyl alpha glucosaminidase; N acetylglucosaminidase; alpha; N-acetyl-alpha-glucosaminidase; NAG; NAGLU; UFHSD 1; UFHSD; UFHSD1
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區域：
    24-743
  • 氨基酸序列
    DEAREAA AVRALVARLL GPGPAADFSV SVERALAAKP GLDTYSLGGG GAARVRVRGS TGVAAAAGLH RYLRDFCGCH VAWSGSQLRL PRPLPAVPGE LTEATPNRYR YYQNVCTQSY SFVWWDWARW EREIDWMALN GINLALAWSG QEAIWQRVYL ALGLTQAEIN EFFTGPAFLA WGRMGNLHTW DGPLPPSWHI KQLYLQHRVL DQMRSFGMTP VLPAFAGHVP EAVTRVFPQV NVTKMGSWGH FNCSYSCSFL LAPEDPIFPI IGSLFLRELI KEFGTDHIYG ADTFNEMQPP SSEPSYLAAA TTAVYEAMTA VDTEAVWLLQ GWLFQHQPQF WGPAQIRAVL GAVPRGRLLV LDLFAESQPV YTRTASFQGQ PFIWCMLHNF GGNHGLFGAL EAVNGGPEAA RLFPNSTMVG TGMAPEGISQ NEVVYSLMAE LGWRKDPVPD LAAWVTSFAA RRYGVSHPDA GAAWRLLLRS VYNCSGEACR GHNRSPLVRR PSLQMNTSIW YNRSDVFEAW RLLLTSAPSL ATSPAFRYDL LDLTRQAVQE LVSLYYEEAR SAYLSKELAS LLRAGGVLAY ELLPALDEVL ASDSRFLLGS WLEQARAAAV SEAEADFYEQ NSRYQLTLWG PEGNILDYAN KQLAGLVANY YTPRWRLFLE ALVDSVAQGI PFQQHQFDKN VFQLEQAFVL SKQRYPSQPR GDTVDLAKKI FLKYYPRWVA GSW
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Involved in the degradation of heparan sulfate.
  • 基因功能參考文獻：
    1. findings show that the NAGLU protein consists of a precursor and a mature form and that in slowly progressing mucopolysaccharidosis type IIIB patients' fibroblasts only the precursor protein is present at 37 degrees ; culturing at lower temperatures resulted in the formation of the mature, enzymatically active form, due to higher mRNA levels and improved processing PMID: 28751108
    2. CSF enzyme activity levels for either SGSH (in MPS IIIA subjects) or NAGLU (in MPS IIIB) significantly differed from normal controls. Several other behavioral or functional measures were found to be uninformative in this population, including timed functional motor tests. PMID: 27590925
    3. Mutation in NAGLU gene is associated with atypical mucopolysaccharidosis IIIB. PMID: 28306536
    4. in the current meta-analysis, based on ten prospective studies involving 29366 participants, we evaluated the role of urinary tubular injury markers (NGAL, KIM-1 and NAG) in predicting clinical outcomes including CKD stage 3, end stage renal disease and mortality. PMID: 27907168
    5. Mutations in NAGLU gene is associated with idiopathic progressive cognitive decline. PMID: 25466957
    6. Plasma NAG correlates with gastrointestinal cancer outcomes. PMID: 25040106
    7. study reports that carriers from two families of a severe pathogenic mutation in NAGLU develop a late dominant painful axonal sensory neuropathy. PMID: 25818867
    8. A modified recombinant NAGLU fused to the receptor-binding motif of insulin-like growth factor (IGF)-II enhances its ability to enter cells using the mannose 6-phosphate receptor, which is the receptor for IGF-II at a different binding site. PMID: 24266751
    9. The research may enrich the mutation spectrum of the NAGLU gene in the Chinese population and help us further in understanding the pathogenesis of MPS IIIB. PMID: 23380547
    10. Urinary NAG/Cr may be a useful surrogate marker for renal function in ADPKD patients. PMID: 22935351
    11. This study suggests a possible role of NAGLU in susceptibility to PD while extending evidence for alpha-synuclein aggregation in the brain in lysosomal storage disorders. PMID: 22102531
    12. We have identified an 1146 bp intragenic deletion of the NAGLU gene within consanguineous parents having two children affected with Sanfilippo syndrome type B. PMID: 20138557
    13. Molecular genetics of mucopolysaccharidosis type IIIA and IIIB: Diagnostic, clinical, and biological implications PMID: 11668611
    14. Sanfilippo syndrome (subtypes A and B) in Turkey: identification of novel mutations in SGSH and NAGLU PMID: 11793481
    15. The NAGLU gene in 11 Mucopolysaccharidosis type IIIB Portuguese patients, was examined, having identified five novel (M1K, W147X, G304V, S522P, and R533X) and four previously reported mutations (W168X, R234C, R565W and R643C). PMID: 18218046

    顯示更多

    收起更多

  • 相關疾病：
    Mucopolysaccharidosis 3B (MPS3B); Charcot-Marie-Tooth disease 2V (CMT2V)
  • 亞細胞定位：
    Lysosome.
  • 蛋白家族：
    Glycosyl hydrolase 89 family
  • 組織特異性：
    Liver, ovary, peripheral blood leukocytes, testis, prostate, spleen, colon, lung, placenta and kidney.
  • 數據庫鏈接：

    HGNC: 7632

    OMIM: 252920

    KEGG: hsa:4669

    STRING: 9606.ENSP00000225927

    UniGene: Hs.50727



主站蜘蛛池模板： 久久99精品久久久久久2021| 免费看国产曰批40分钟| 亚洲精品v天堂中文字幕 | 137裸交肉体摄影| 无码人妻久久一区二区三区app| 国语自产精品视频在线看| 好吊视频一区二区三区| 免费裸体黄网站18禁免费| 国产精品麻豆aⅴ人妻| 熟妇高潮精品一区二区三区| 国产情侣久久久久aⅴ免费| 狠狠躁夜夜躁人人爽天天| 日韩a人毛片精品无人区乱码| 欧美日本精品一区二区三区| 女人张开腿让男人桶个爽| 99久久国产精品免费高潮| 久久婷婷五月综合色俺也想去| 少妇人妻无码专区视频| 10000部拍拍拍免费视频| 少妇白浆呻吟爽| 99大香伊乱码一区二区| 少妇被爽到高潮喷水久久欧美精品| 小sao货水好多真紧h无码视频| 亚洲国产精品嫩草影院永久| 99热在线精品国产观看| 成人免费视频一区二区三区| 四虎影视国产精品久久| 无码人妻久久1区2区3区| 精品国产一区二区三区四区| 国产人妻丰满熟妇嗷嗷叫| 特黄做受又粗又长又大又硬| 日本日本乱码伦专区| 午夜精品久久久久久久| 日韩人妻无码制服丝袜视频| 欧美日本日韩aⅴ在线视频| 一二三四区无产乱码1000集| 欧美亚洲国产成人一区二区三区| 久久天天躁狠狠躁夜夜夜| 欧美性潮喷xxxxx免费视频看 | 国产 成人 综合 亚洲 网站| 国产精品久久久久久人妻精品动漫|