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  4. Recombinant Human Alpha-2,8-sialyltransferase 8B (ST8SIA2), partial

Recombinant Human Alpha-2,8-sialyltransferase 8B (ST8SIA2), partial

  • 中文名稱：
    人ST8SIA2重組蛋白
  • 貨號：
    CSB-YP852840HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人ST8SIA2重組蛋白
  • 貨號：
    CSB-EP852840HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人ST8SIA2重組蛋白
  • 貨號：
    CSB-EP852840HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人ST8SIA2重組蛋白
  • 貨號：
    CSB-BP852840HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人ST8SIA2重組蛋白
  • 貨號：
    CSB-MP852840HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    ST8SIA2
  • Uniprot No.：
  • 別名：
    ST8SIA2; SIAT8B; STX; Alpha-2,8-sialyltransferase 8B; EC 2.4.99.-; Sialyltransferase 8B; SIAT8-B; Sialyltransferase St8Sia II; ST8SiaII; Sialyltransferase X; STX
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    May transfer sialic acid through alpha-2,8-linkages to the alpha-2,3-linked and alpha-2,6-linked sialic acid of N-linked oligosaccharides of glycoproteins and may be involved in PSA (polysialic acid) expression.
  • 基因功能參考文獻：
    1. The ST8SIA2 risk haplotype copy number did not show any differential effects on white matter in schizophrenia. PMID: 29353880
    2. impairment of the regulated expression of ST8SIA2 and the resulting downstream effects on gene products by these two intronic single nucleotide polymorphism contribute to the development of these psychiatric disorders. PMID: 27565727
    3. ST8SiaII role in the invasiveness and metastasis of small cell lung cancer cells PMID: 28004110
    4. the relationships between psychiatric disorders and polySia and/or ST8SIA2 PMID: 27105834
    5. Data indicate a possible role of STX polysialyltransferase (ST8SIA2) in the common susceptibility of schizophrenia and bipolar I disorder (BD-I). PMID: 26418860
    6. Our study showed interesting sex-specific associations between ST8SIAII and schizophrenia. PMID: 24070986
    7. the role of ST8SIA2 sequence variation affecting polysialic acid-NCAM formation in 48 Caucasian cases with bipolar disorder PMID: 24651862
    8. translational modification of the neural cell adhesion molecule NCAM and the polysialyltransferase ST8SiaII in mammalian semen involves polysialic acid PMID: 23671285
    9. Expression of ST8SIA2 in omental fat at baseline was significantly associated with weight loss after Roux-en-Y gastric bypass. PMID: 23643386
    10. that variation the ST8SIA2 gene is associated with increased risk to mental illness PMID: 22693595
    11. NCAM and polySia are expressed and developmentally regulated in chick corneas. Both membrane-associated and soluble NCAM isoforms are expressed in chick corneas. PMID: 22281821
    12. ST8SIA2 is a target gene of the BACH1 transcription factor according to ChIP-seq analysis in HEK 293 cells. PMID: 21555518
    13. STX(G421A) shows a dramatic decrease in polySia synthetic activity on NCAM, whereas STX(C621G) does not; polySia shows a dopamine (DA) binding activity PMID: 21464126
    14. This study provided that ST8SIA2 are associated with Bipolar I in the Han Chinese population. PMID: 20386566
    15. SIAT8B has a role in neural development and sialic acid synthesis on NCAM PMID: 12138100
    16. SIAT8B gene is involved in schizophrenia in the Japanese. PMID: 16229822

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  • 亞細胞定位：
    Golgi apparatus membrane; Single-pass type II membrane protein.
  • 蛋白家族：
    Glycosyltransferase 29 family
  • 組織特異性：
    Highly expressed in fetal brain, kidney and heart and to a much lesser extent in adult heart and thymus.
  • 數據庫鏈接：

    HGNC: 10870

    OMIM: 602546

    KEGG: hsa:8128

    STRING: 9606.ENSP00000268164

    UniGene: Hs.302341



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