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  4. Recombinant Human Alanine--glyoxylate aminotransferase 2, mitochondrial (AGXT2)

Recombinant Human Alanine--glyoxylate aminotransferase 2, mitochondrial (AGXT2)

  • 中文名稱：
    Recombinant Human Alanine--glyoxylate aminotransferase 2, mitochondrial(AGXT2)
  • 貨號：
    CSB-YP866322HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human Alanine--glyoxylate aminotransferase 2, mitochondrial(AGXT2)
  • 貨號：
    CSB-EP866322HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human Alanine--glyoxylate aminotransferase 2, mitochondrial(AGXT2)
  • 貨號：
    CSB-EP866322HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human Alanine--glyoxylate aminotransferase 2, mitochondrial(AGXT2)
  • 貨號：
    CSB-BP866322HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human Alanine--glyoxylate aminotransferase 2, mitochondrial(AGXT2)
  • 貨號：
    CSB-MP866322HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    AGXT2
  • Uniprot No.：
  • 別名：
    AGXT2; AGT2Alanine--glyoxylate aminotransferase 2; mitochondrial; AGT 2; EC 2.6.1.44,; R)-3-amino-2-methylpropionate--pyruvate transaminase; EC 2.6.1.40; Beta-ALAAT II; Beta-alanine-pyruvate aminotransferase; D-AIBAT
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區域：
    42-514
  • 氨基酸序列
    LHTKPRMPP CDFMPERYQS LGYNRVLEIH KEHLSPVVTA YFQKPLLLHQ GHMEWLFDAE GSRYLDFFSG IVTVSVGHCH PKVNAVAQKQ LGRLWHTSTV FFHPPMHEYA EKLAALLPEP LKVIFLVNSG SEANELAMLM ARAHSNNIDI ISFRGAYHGC SPYTLGLTNV GTYKMELPGG TGCQPTMCPD VFRGPWGGSH CRDSPVQTIR KCSCAPDCCQ AKDQYIEQFK DTLSTSVAKS IAGFFAEPIQ GVNGVVQYPK GFLKEAFELV RARGGVCIAD EVQTGFGRLG SHFWGFQTHD VLPDIVTMAK GIGNGFPMAA VITTPEIAKS LAKCLQHFNT FGGNPMACAI GSAVLEVIKE ENLQENSQEV GTYMLLKFAK LRDEFEIVGD VRGKGLMIGI EMVQDKISCR PLPREEVNQI HEDCKHMGLL VGRGSIFSQT FRIAPSMCIT KPEVDFAVEV FRSALTQHME RRAK
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Can metabolize asymmetric dimethylarginine (ADMA) via transamination to alpha-keto-delta-(NN-dimethylguanidino) valeric acid (DMGV). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure.
  • 基因功能參考文獻：
    1. We purified human AGXT2 from tissues of AGXT2 transgenic mice and demonstrated its ability to metabolize homoarginine to 6-guanidino-2-oxocaproic acid (GOCA). After incubation of HepG2 cells overexpressing AGXT2 with isotope-labeled homoarginine-d4 we were able to detect labeled GOCA in the medium PMID: 27752063
    2. study in a well-characterized rheumatoid arthritis population did not show an association between serum concentrations of dimethylarginines and genetic variants of the AGXT2 gene. PMID: 28357606
    3. AGXT2 rs37369 polymorphism is associated with increased risk for chronic heart failure, which may due to distinct disparities of alleles in asymmetric dimethylarginine degradation PMID: 27423328
    4. Single nucleotide polymorphism in AGXT2 gene is associated with renal dysfunction in patients with chronic heart failure. PMID: 28942034
    5. The Alanine-glyoxylate aminotransferase 2 p.V498L polymorphism is associated with both paroxysmal and chronic forms of atrial fibrillation in coronary angiographic patients without structural heart disease in ultrasound, and earlier age at onset of ischemic stroke in patients undergoing exercise stress testing. PMID: 26984639
    6. AGXT2 rs37369 polymorphism is associated with increased risk for CHD in smokers and in diabetes mellitus patients PMID: 24834905
    7. The AGXT2 genotype may be an important factor underlying atherosclerosis. PMID: 25620171
    8. The results of this study that the AGXT2 gene is not associated with schizophrenia in Japanese subjects. PMID: 24727203
    9. SNPs of AGXT2 affect plasma as well as urinary BAIB. PMID: 24586340
    10. AGXT2 has an important role in SDMA metabolism in humans and may additionally have an unanticipated role in the autonomic nervous system regulation of cardiac function. PMID: 24159190
    11. Alanine-glyoxylate aminotransferase-2 metabolizes endogenous methylarginines, regulates NO, and controls blood pressure. PMID: 23023372
    12. mitochondrially localized human AGXT2 is able to effectively metabolize ADMA in vivo resulting in decreased ADMA levels and improved endothelial NO production. PMID: 20018850
    13. Discusses the cloning of the rat gene. PMID: 7592550

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  • 亞細胞定位：
    Mitochondrion.
  • 蛋白家族：
    Class-III pyridoxal-phosphate-dependent aminotransferase family
  • 數據庫鏈接：

    HGNC: 14412

    OMIM: 210100

    KEGG: hsa:64902

    STRING: 9606.ENSP00000231420

    UniGene: Hs.34494



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