在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Actin-like protein 6B (ACTL6B)

In Stock
  • 貨號:
    CSB-EP001237HU
  • 規(guī)格:
    ¥2328
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產(chǎn)品詳情

  • 純度:
    Greater than 90% as determined by SDS-PAGE.
  • 基因名:
    ACTL6B
  • Uniprot No.:
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Full Length
  • 來源:
    E.coli
  • 分子量:
    48.8 kDa
  • 表達(dá)區(qū)域:
    1-426aa
  • 氨基酸序列
    MSGGVYGGDEVGALVFDIGSFSVRAGYAGEDCPKADFPTTVGLLAAEEGGGLELEGDKEKKGKIFHIDTNALHVPRDGAEVMSPLKNGMIEDWECFRAILDHTYSKHVKSEPNLHPVLMSEAPWNTRAKREKLTELMFEQYNIPAFFLCKTAVLTAFANGRSTGLVLDSGATHTTAIPVHDGYVLQQGIVKSPLAGDFISMQCRELFQEMAIDIIPPYMIAAKEPVREGAPPNWKKKEKLPQVSKSWHNYMCNEVIQDFQASVLQVSDSPYDEQVAAQMPTVHYEMPNGYNTDYGAERLRIPEGLFDPSNVKGLSGNTMLGVGHVVTTSIGMCDIDIRPGLYGSVIVTGGNTLLQGFTDRLNRELSQKTPPSMRLKLIASNSTMERKFSPWIGGSILASLGTFQQMWISKQEYEEGGKQCVERKCP
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標(biāo)簽:
    C-terminal 6xHis-Flag-tagged
  • 產(chǎn)品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 復(fù)溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    3-7 business days
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能:
    Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex), as such plays a role in remodeling mononucleosomes in an ATP-dependent fashion, and is required for postmitotic neural development and dendritic outgrowth. During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. ACTL6B/BAF53B is not essential for assembly of the nBAF complex but is required for targeting the complex and CREST to the promoter of genes essential for dendritic growth. Essential for neuronal maturation and dendrite development.
  • 基因功能參考文獻(xiàn):
    1. Missense Mutation in ACTL6B gene is associated with Neurodevelopmental Disorders. PMID: 28867141
    2. we identified BAF53b as a neuron-specific subunit of the chromatin remodeling BAF complexes. PMID: 26077106
    3. Data suggest that SWI/SNF complexes containing ArpN alpha might regulate certain genes involved in brain development and/or its function differently from SWI/SNF complexes containing ArpN beta/BAF53. PMID: 12565893
  • 亞細(xì)胞定位:
    Nucleus.
  • 蛋白家族:
    Actin family
  • 數(shù)據(jù)庫鏈接:

    HGNC: 160

    OMIM: 612458

    KEGG: hsa:51412

    STRING: 9606.ENSP00000160382

    UniGene: Hs.259831



主站蜘蛛池模板: 国产亚洲精品一区二区三区| 色婷婷五月综合色啪网| 久爱www成人网免费视频| 丰满岳乱妇在线观看中字无码 | 欧美黑人性暴力猛交喷水| 欧美自拍另类欧美综合图片区 | 无套内谢老熟女| 3p人妻少妇对白精彩视频| 欧美变态另类牲交| 国产高清不卡一区二区| 成人无码www免费视频| 特级a做爰全过程片| 777米奇影院狠狠色| 华人少妇被黑人粗大的猛烈进| 亚洲大尺度无码无码专线一区| 内射老妇bbwx0c0ck| 色综合天天视频在线观看| 东京热加勒比视频一区| 中日韩精品视频在线观看| 欧美巨大另类极品videosbest| 亚洲欧洲av无码专区| 无遮挡18禁啪啪免费观看| 国产精品一区二区av不卡| 红杏亚洲影院一区二区三区| 亚洲精品色播一区二区| 人妻在线无码一区二区三区| 日本大尺度吃奶呻吟视频| 熟女人妻aⅴ一区二区三区麻豆| 插插插精品亚洲一区| 亚洲精品久久| 无码人妻丰满熟妇区五十路| 欧美综合自拍亚洲综合区| 中国丰满少妇人妻xxx性董鑫洁| 亚洲精品国偷拍自产在线观看蜜臀| 国产xxxx69真实实拍| 2019久久久最新精品| 免费又黄又硬又爽大片| 永久免费观看美女裸体的网站| 熟女人妻高清一区二区三区| 男人和女人做爽爽视频| 亚洲国产另类久久久精品黑人|