在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Acetyl-CoA carboxylase 2 (ACACB), partial

  • 中文名稱:
    Recombinant Human Acetyl-CoA carboxylase 2(ACACB) ,partial
  • 貨號(hào):
    CSB-YP001120HU
  • 規(guī)格:
  • 來(lái)源:
    Yeast
  • 其他:
  • 中文名稱:
    Recombinant Human Acetyl-CoA carboxylase 2(ACACB) ,partial
  • 貨號(hào):
    CSB-EP001120HU
  • 規(guī)格:
  • 來(lái)源:
    E.coli
  • 其他:
  • 中文名稱:
    Recombinant Human Acetyl-CoA carboxylase 2(ACACB) ,partial
  • 貨號(hào):
    CSB-EP001120HU-B
  • 規(guī)格:
  • 來(lái)源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    Recombinant Human Acetyl-CoA carboxylase 2(ACACB) ,partial
  • 貨號(hào):
    CSB-BP001120HU
  • 規(guī)格:
  • 來(lái)源:
    Baculovirus
  • 其他:
  • 中文名稱:
    Recombinant Human Acetyl-CoA carboxylase 2(ACACB) ,partial
  • 貨號(hào):
    CSB-MP001120HU
  • 規(guī)格:
  • 來(lái)源:
    Mammalian cell
  • 其他:

產(chǎn)品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    ACACB; ACACB_HUMAN; ACC-beta; ACC2; ACCB; Acetyl CoA carboxylase beta; Biotin carboxylase; HACC275
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長(zhǎng)度:
    Partial
  • 蛋白標(biāo)簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng):
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Mitochondrial enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA and plays a central role in fatty acid metabolism. Catalyzes a 2 steps reaction starting with the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA. Through the production of malonyl-CoA that allosterically inhibits carnitine palmitoyltransferase 1 at the mitochondria, negatively regulates fatty acid oxidation. Together with its cytosolic isozyme ACACA, which is involved in de novo fatty acid biosynthesis, promotes lipid storage.
  • 基因功能參考文獻(xiàn):
    1. ACC2 gene (ACACB) expression was decreased by 25% in HCC tissue compared to non-cancerous liver tissue. PMID: 28290443
    2. PHD3 loss in cancer enables metabolic reliance on fatty acid oxidation via deactivation of ACC2. PMID: 27635760
    3. A significant association exists of ACACB gene polymorphism and diabetic nephropathy among Caucasian patients with diabetes. PMID: 26030797
    4. Our meta-analysis supports that the apolipoprotein E epsilon2 allele and acetyl-CoA carboxylase beta rs2268388 C>T might act as promotion factors of nephropathy in type 2 diabetes. PMID: 25262148
    5. The knockdown of ACC2 reduced palmitic acid -induced autophagy and thus protects the cells from palmitic acid - induced lipotoxicity with attenuated lipid accumulation and rescued cell viability. PMID: 26022126
    6. These data support a role for ACACB in obesity and potential roles for altered lipid metabolism in susceptibility to diabetic nephropathy. PMID: 23460794
    7. TT genotypes of ACACB gene (rs2268388) and CC genotype of AGTR1 gene (rs5186) confers the risk of diabetic nephropathy in Asian Indian patients with T2DM. PMID: 23081748
    8. Its involvement in the development of diabetic nephropathy is explained by the promotion of the so-called micro-inflammation associated with the diabetic state. PMID: 23156397
    9. A gene polymorphism in acetyl-coenzyme A carboxylase beta may be associated with the C-reactive protein level in a prediabetic and diabetic population. PMID: 21553357
    10. In conclusion, common polymorphisms of ACACB gene are associated with obesity and, independently, with type 2 diabetes in postmenopausal women PMID: 21908218
    11. Common variants within the ACACB locus appear to regulate adipose gene expression PMID: 21887335
    12. Structure-guided inhibitor design for human acetyl-coenzyme A carboxylase by interspecies active site conversion. PMID: 21953464
    13. The acetyl-coenzyme A carboxylase beta (ACACB) gene is associated with nephropathy in Chinese patients with type 2 diabetes. PMID: 20519229
    14. Acetyl-CoA carboxylase beta (ACC2) plays a key role in fatty acid synthesis and oxidation pathways. PMID: 20855566
    15. The -368 C/T single-nucleotide polymorphism in ACACB P-II binds HepG2 nuclear proteins that affect promoter activity in an allele-specific fashion. PMID: 20799892
    16. ACACB overexpression in renal proximal tubular epithelial cell increased proinflammatory cytokine expression, such as IL-6, at least partly by increasing mRNA stability through a p38 MAPK-dependent pathway. PMID: 20514549
    17. This study demonstrates that NRF-1 is a novel transcriptional inhibitor of the human ACCbeta gene promoter in the mammalian heart. PMID: 20599696
    18. These results suggest that ACACB is a strong candidate for conferring susceptibility for proteinuria in patients with type 2 diabetes. PMID: 20168990
    19. the crystal structures of the biotin carboxylase domain of human ACC2 phosphorylated by AMP-activated protein kinase was reported. PMID: 19900410
    20. The effect of a 3-month low-intensity endurance training program on fat oxidation and expression PMID: 12086953
    21. elevation of AMPK via phosphorylation is not sufficient to maintain elevated ACCbeta Ser(221) phosphorylation during exercise PMID: 12413941
    22. down-regulation of acetyl coa carboxylase 2 (ACC2) mRNA, induced by the lowering of plasma insulin concentration, is related to improvement of insulin sensitivity PMID: 14627750
    23. differential regulation of ACCbeta gene expression between tissues PMID: 15590647
    24. The expression, purification, and characterization of ACC2 were investigated. PMID: 17223360
    25. Human adipose tissue, unlike rodent adipose, expresses more ACC2 mRNA relative to the oxidative tissues muscle and heart. PMID: 19190759
    26. The human ACC2 CT-domain C-terminus is comprised of three intertwined alpha-helices that extend outwards from the enzyme on the opposite side to the ligand-binding site. PMID: 19390150
    27. results point towards major differences in ACC tissue distribution between humans and rats PMID: 19618481

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Mitochondrion.
  • 組織特異性:
    Widely expressed with highest levels in heart, skeletal muscle, liver, adipose tissue, mammary gland, adrenal gland and colon. Isoform 3 is expressed in skeletal muscle, adipose tissue and liver (at protein level). Isoform 3 is detected at high levels in
  • 數(shù)據(jù)庫(kù)鏈接:

    HGNC: 85

    OMIM: 601557

    KEGG: hsa:32

    STRING: 9606.ENSP00000341044

    UniGene: Hs.234898



主站蜘蛛池模板: 国产精品白丝av在线观看播放| 人妻少妇av中文字幕乱码| 国产麻豆剧传媒精品国产av| 国产色在线 | 亚洲| 欧美一性一乱一交一视频| 小12萝裸体自慰出白浆| 国产精品∧v在线观看| 人妻在线日韩免费视频| 性一交一乱一色一视频| 国产国产久热这里只有精品| 99热成人精品国产免费| 国产成人a∨激情视频厨房| 四虎国产精品永久在线| 成人爽a毛片免费网站| 久久久久国产精品人妻电影| 亚洲最大av网站在线观看| 最爽free性欧美人妖| 国产成人+亚洲欧洲+综合| 无码中文字幕免费一区二区三区| 国产精品人妻熟女男人的天堂| 无码人妻一区二区三区免费看成人| 色爱区综合五月激情| 久久婷婷六月综合色液啪| 精品国产成人网站一区在线| 乱人伦人妻中文字幕无码| 无码人妻品一区二区三区精99 | 在线观看特色大片免费视频| 无码区国产区在线播放| 欧美变态暴力牲交videos| 99精品热在线在线观看视频| 国产在线视频一区二区三区98| 99精品视频九九精品视频| 成人国产mv免费视频| 三级无码在钱av无码在钱| 免费人成在线观看| 亚洲日韩国产二区无码| 午夜伦4480yy私人影院久久| av片在线播放| 免费观看全黄做爰的视频| 精品国产乱码久久久久久乱码| 97在线观看播放|