Recombinant Human ATP-dependent RNA helicase DHX29 (DHX29), partial

中文名稱：

人DHX29重組蛋白
貨號：

CSB-YP801807HU
規(guī)格：
來源：

Yeast
其他：

中文名稱：

人DHX29重組蛋白
貨號：

CSB-EP801807HU
規(guī)格：
來源：

E.coli
其他：

中文名稱：

人DHX29重組蛋白
貨號：

CSB-EP801807HU-B
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人DHX29重組蛋白
貨號：

CSB-BP801807HU
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

人DHX29重組蛋白
貨號：

CSB-MP801807HU
規(guī)格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

DHX29
Uniprot No.：

Q7Z478
別名：

DHX29; DDX29ATP-dependent RNA helicase DHX29; EC 3.6.4.13; DEAH box protein 29; Nucleic acid helicase DDXx
種屬：

Homo sapiens (Human)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

ATP-binding RNA helicase involved in translation initiation. Part of the 43S pre-initiation complex that is required for efficient initiation on mRNAs of higher eukaryotes with structured 5'-UTRs by promoting efficient NTPase-dependent 48S complex formation. Specifically binds to the 40S ribosome near the mRNA entrance. Does not possess a processive helicase activity.
基因功能參考文獻：
1. A critical role for DHX29 in innate immune response; molecular insights into the mechanisms by which DHX29 recognizes 5' structured EMCV RNA and interacts with MDA5 for potent type I interferon signaling and antiviral immunity. PMID: 29462185
2. DHX29 and eIF3 cooperate in scanning on structured mRNAs. Our findings support previous genetic data on the role of eIF3 during scanning PMID: 27733651
3. DHX29 is another example of an initiation factor contributing to start codon selection. PMID: 27067542
4. Helicase proteins DHX29 and RIG-I cosense cytosolic nucleic acids in the human airway system. PMID: 24821782
5. Roles of individual domains in the function of DHX29, an essential factor required for translation of structured mammalian mRNAs. PMID: 23047696
6. Down-regulation of DHX29 leads to impaired translation, resulting in disassembly of polysomes and accumulation of mRNA-free 80S monomers. DHX29 depletion also impedes cancer cell growth in culture and in xenografts. PMID: 20018725
7. Study reports that these 7 eIFs are not sufficient for efficient 48S complex formation on mRNAs with highly structured 5'UTRs, and that this process requires the DExH-box protein DHX29. PMID: 19109895
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亞細胞定位：

Cytoplasm.
蛋白家族：

DEAD box helicase family, DEAH subfamily
數(shù)據庫鏈接：

HGNC: 15815

OMIM: 612720

KEGG: hsa:54505

STRING: 9606.ENSP00000251636

UniGene: Hs.593268