在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human ATP-binding cassette sub-family A member 2 (ABCA2), partial

Recombinant Human ATP-binding cassette sub-family A member 2 (ABCA2), partial

  • 中文名稱：
    Recombinant Human ATP-binding cassette sub-family A member 2(ABCA2) ,partial
  • 貨號(hào)：
    CSB-YP887172HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human ATP-binding cassette sub-family A member 2(ABCA2) ,partial
  • 貨號(hào)：
    CSB-EP887172HU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human ATP-binding cassette sub-family A member 2(ABCA2) ,partial
  • 貨號(hào)：
    CSB-EP887172HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human ATP-binding cassette sub-family A member 2(ABCA2) ,partial
  • 貨號(hào)：
    CSB-BP887172HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human ATP-binding cassette sub-family A member 2(ABCA2) ,partial
  • 貨號(hào)：
    CSB-MP887172HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    ABC2; Abca2; ABCA2_HUMAN; ATP binding cassette 2; ATP binding cassette sub family A member 2; ATP binding cassette transporter 2; ATP binding cassette; sub family A (ABC1); member 2; ATP binding cassette; sub family A; member 2; ATP binding cassette; sub family B (MDR/TAP); member 2; ATP-binding cassette 2; ATP-binding cassette sub-family A member 2; ATP-binding cassette transporter 2
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Probable lipid transporter that modulates cholesterol sequestration in the late endosome/lysosome by regulating the intracellular sphingolipid metabolism, in turn participates in cholesterol homeostasis (Probable). May alter the transbilayer distribution of ceramide in the intraluminal membrane lipid bilayer, favoring its retention in the outer leaflet that results in increased acid ceramidase activity in the late endosome/lysosome, facilitating ceramide deacylation to sphingosine leading to the sequestration of free cholesterol in lysosomes. In addition regulates amyloid-beta production either by activating a signaling pathway that regulates amyloid precursor protein transcription through the modulation of sphingolipid metabolism or through its role in gamma-secretase processing of APP. May play a role in myelin formation.
  • 基因功能參考文獻(xiàn)：
    1. The analyses results suggested ABCA2 mRNA expression was upregulated significantly in AD compared with controls in all datasets. PMID: 29224028
    2. Our findings indicate a considerable and direct relationship between mRNA expression levels of ABCA2, ABCA3, MDR1, and MRP1 genes and positive minimal residual disease (MRD) measured after one year of treatment. PMID: 24145140
    3. Down-regulation of the ATP-binding cassette transporter 2 (Abca2) reduces amyloid-beta production by altering Nicastrin maturation and intracellular localization. PMID: 22086926
    4. SLC2A1/GLUT1, SLC1A3/EAAT1, and SLC1A2/EAAT2 were the main SLC proteins whereas ABCG2/BCRP, ABCB1/MDR1, ABCA2 and ABCA8 were the main ABC quantified in isolated brain microvessels PMID: 21707071
    5. A possible biochemical mechanism links ABCA2 expression, amyloid precursor protein processing, and Alzheimer's disease. PMID: 20704561
    6. we demonstrate that ABCA2-deficiency inhibits prostate tumor metastasis in vivo and decreases chemotactic potential of cells PMID: 21041019
    7. roles for this largest known ABC protein in neural transmembrane lipid export PMID: 12363033
    8. Reciprocal regulation of expression of the ABCA2 promoter by the early growth response-1 and Sp-family transcription factors. PMID: 12560508
    9. It is likely that expression of ABCA2 by two independent promoters constitutes locus of regulation controlling expression of the protein to meet requirements in different tissues. PMID: 15093135
    10. Increased expression of ABCA2 may be causally linked with altered expression of genes associated with the pathogenesis of Alzheimer disease. PMID: 15155565
    11. Among the 45 ABCA2 single nucleotide polymorphisms(SNPs) we tested, one synonymous SNP (rs908832) was found significantly associated with AD in both samples. PMID: 15649702
    12. the expression patterns of ABCA2 in combination with other markers showed phenotypic heterogeneity in schwannomas PMID: 15850583
    13. Data suggest that ABCA2 may exert population-dependent effects on the genetic risk for sporadic Alzheimer's disease and support a role of ABC lipid transporters in the pathogenesis of this disease. PMID: 16752360
    14. No association of ABCA2 Single Nucleotide Polymorphism on chromosome 9 with Alzheimer's disease. PMID: 18336955

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein.
  • 蛋白家族：
    ABC transporter superfamily, ABCA family
  • 組織特異性：
    [Isoform 3]: Highly expressed in the brain,peripheral blood leukocytes and ovary, whereas lower levels of expression is observed in kidney and liver.; [Isoform 4]: Weakly expressed in brain and highly in peripheral blood leukocytes.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 32

    OMIM: 600047

    KEGG: hsa:20

    STRING: 9606.ENSP00000344155

    UniGene: Hs.421202



主站蜘蛛池模板： 无码av大香线蕉| 我的性奴的肉玩具1一17心奴| 国产真人性做爰久久网站| av人摸人人人澡人人超碰下载| 中国妇女做爰视频| 免费无遮挡无码视频网站| 欧美日韩精品无码一本二本三本色| 麻豆日产精品卡2卡3卡4卡5卡| 国产手机在线无码播放视频| 亚洲一区二区三区四区五区六 | 99尹人香蕉国产免费天天| 最新亚洲伦理中文字幕| 亚洲精品无码ma在线观看| 夜夜躁很很躁日日躁麻豆| 99国产欧美久久久精品蜜芽| 欧美孕妇变态孕交粗暴| 亚洲成a人v电影在线观看| 久久精品国产99久久6| 国精产品一二三区精华液| 国产免费一区二区视频| 全部露出来毛走秀福利视频| 717影院理论午夜伦八戒| 屁屁影院ccyy备用地址| 女人18毛片水最多| 人妻系列无码专区喂奶 | 中文字幕无线观看中文字幕| 疯狂做受xxxx高潮视频免费| 亚洲欧美日韩成人一区二区三区| 国产精品三级av及在线观看| 乱码国产丰满人妻www| 五月花成人网| 在线不卡日本v一区二区| 秋霞在线观看片无码免费不卡| 亚洲bbw性色大片| 亚洲人av高清无码| 国内精品久久久久久久影视| 日韩av无码一区二区三区不卡毛片 | 播五月开心婷婷欧美综合| 亚洲精品美女久久777777| 国精产品一区一区三区mba下载| 又大又黄又粗又爽的免费视频|