在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. ABCA2 Antibody

ABCA2 Antibody

  • 中文名稱：
    ABCA2兔多克隆抗體
  • 貨號：
    CSB-PA949432
  • 規格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using CSB-PA949432(ABCA2 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using CSB-PA949432(ABCA2 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    ABC2 antibody; Abca2 antibody; ABCA2_HUMAN antibody; ATP binding cassette 2 antibody; ATP binding cassette sub family A member 2 antibody; ATP binding cassette transporter 2 antibody; ATP binding cassette; sub family A (ABC1); member 2 antibody; ATP binding cassette; sub family A; member 2 antibody; ATP binding cassette; sub family B (MDR/TAP); member 2 antibody; ATP-binding cassette 2 antibody; ATP-binding cassette sub-family A member 2 antibody; ATP-binding cassette transporter 2 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Synthetic peptide of Human ABCA2
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:25-1:100
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Probable lipid transporter that modulates cholesterol sequestration in the late endosome/lysosome by regulating the intracellular sphingolipid metabolism, in turn participates in cholesterol homeostasis (Probable). May alter the transbilayer distribution of ceramide in the intraluminal membrane lipid bilayer, favoring its retention in the outer leaflet that results in increased acid ceramidase activity in the late endosome/lysosome, facilitating ceramide deacylation to sphingosine leading to the sequestration of free cholesterol in lysosomes. In addition regulates amyloid-beta production either by activating a signaling pathway that regulates amyloid precursor protein transcription through the modulation of sphingolipid metabolism or through its role in gamma-secretase processing of APP. May play a role in myelin formation.
  • 基因功能參考文獻：
    1. The analyses results suggested ABCA2 mRNA expression was upregulated significantly in AD compared with controls in all datasets. PMID: 29224028
    2. Our findings indicate a considerable and direct relationship between mRNA expression levels of ABCA2, ABCA3, MDR1, and MRP1 genes and positive minimal residual disease (MRD) measured after one year of treatment. PMID: 24145140
    3. Down-regulation of the ATP-binding cassette transporter 2 (Abca2) reduces amyloid-beta production by altering Nicastrin maturation and intracellular localization. PMID: 22086926
    4. SLC2A1/GLUT1, SLC1A3/EAAT1, and SLC1A2/EAAT2 were the main SLC proteins whereas ABCG2/BCRP, ABCB1/MDR1, ABCA2 and ABCA8 were the main ABC quantified in isolated brain microvessels PMID: 21707071
    5. A possible biochemical mechanism links ABCA2 expression, amyloid precursor protein processing, and Alzheimer's disease. PMID: 20704561
    6. we demonstrate that ABCA2-deficiency inhibits prostate tumor metastasis in vivo and decreases chemotactic potential of cells PMID: 21041019
    7. roles for this largest known ABC protein in neural transmembrane lipid export PMID: 12363033
    8. Reciprocal regulation of expression of the ABCA2 promoter by the early growth response-1 and Sp-family transcription factors. PMID: 12560508
    9. It is likely that expression of ABCA2 by two independent promoters constitutes locus of regulation controlling expression of the protein to meet requirements in different tissues. PMID: 15093135
    10. Increased expression of ABCA2 may be causally linked with altered expression of genes associated with the pathogenesis of Alzheimer disease. PMID: 15155565
    11. Among the 45 ABCA2 single nucleotide polymorphisms(SNPs) we tested, one synonymous SNP (rs908832) was found significantly associated with AD in both samples. PMID: 15649702
    12. the expression patterns of ABCA2 in combination with other markers showed phenotypic heterogeneity in schwannomas PMID: 15850583
    13. Data suggest that ABCA2 may exert population-dependent effects on the genetic risk for sporadic Alzheimer's disease and support a role of ABC lipid transporters in the pathogenesis of this disease. PMID: 16752360
    14. No association of ABCA2 Single Nucleotide Polymorphism on chromosome 9 with Alzheimer's disease. PMID: 18336955

    顯示更多

    收起更多

  • 亞細胞定位：
    Endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein.
  • 蛋白家族：
    ABC transporter superfamily, ABCA family
  • 組織特異性：
    [Isoform 3]: Highly expressed in the brain,peripheral blood leukocytes and ovary, whereas lower levels of expression is observed in kidney and liver.; [Isoform 4]: Weakly expressed in brain and highly in peripheral blood leukocytes.
  • 數據庫鏈接：

    HGNC: 32

    OMIM: 600047

    KEGG: hsa:20

    STRING: 9606.ENSP00000344155

    UniGene: Hs.421202



主站蜘蛛池模板： 免费天堂无码人妻成人av电影| 骚女人干起来舒服视频在线| 女人夜夜春高潮爽a∨片传媒 | 国产偷国产偷亚州清高app| 国产精品久久久久久超碰| 樱花草在线社区www| 精品第一国产综合精品蜜芽| 国产av无码专区亚洲aⅴ| 亚欧色一区w666天堂| 含紧一点h边做边走动免费视频| 亚洲成av人片无码bt种子下载| 体验区试看120秒啪啪免费| 国产亚洲精品成人aa片| 狠狠热精品免费视频| 亚洲欧洲av无码专区| 亚洲欧洲精品无码av| 国产日韩av免费无码一区二区三区| 美女黄18以下禁止观看| 免费高清av一区二区三区| 高中国产开嫩苞实拍视频在线观看| 精品久久久久久中文字幕人妻最新 | 野花社区在线观看视频| 亚洲国产精品一区二区久久hs| 华人在线亚洲欧美精品| 欧洲一卡2卡3卡4卡乱码视频| 欧美牲交40_50a欧美牲交aⅴ| 都市激情 在线 亚洲 国产| 久久激情综合狠狠爱五月| 永久免费看啪啪网址入口| 国产精品免费久久久久影院| 上司揉捏人妻丰满双乳电影| 少妇久久久久久人妻无码| 国产无遮挡吃胸膜奶免费看| 熟妇人妻无码中文字幕老熟妇| 欧美日韩一卡2卡三卡4卡 乱码欧美孕交| 国产亚洲精品在av| 日本精品少妇一区二区三区| 亚洲成a人片77777国产| 亚洲日韩成人无码不卡网站| 成人无码av片在线观看| 国产一区二区三区 韩国女主播 |