在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. ABCA2 Antibody

ABCA2 Antibody

  • 中文名稱：
    ABCA2兔多克隆抗體
  • 貨號：
    CSB-PA949432
  • 規格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using CSB-PA949432(ABCA2 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using CSB-PA949432(ABCA2 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    ABC2 antibody; Abca2 antibody; ABCA2_HUMAN antibody; ATP binding cassette 2 antibody; ATP binding cassette sub family A member 2 antibody; ATP binding cassette transporter 2 antibody; ATP binding cassette; sub family A (ABC1); member 2 antibody; ATP binding cassette; sub family A; member 2 antibody; ATP binding cassette; sub family B (MDR/TAP); member 2 antibody; ATP-binding cassette 2 antibody; ATP-binding cassette sub-family A member 2 antibody; ATP-binding cassette transporter 2 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Synthetic peptide of Human ABCA2
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:25-1:100
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Probable lipid transporter that modulates cholesterol sequestration in the late endosome/lysosome by regulating the intracellular sphingolipid metabolism, in turn participates in cholesterol homeostasis (Probable). May alter the transbilayer distribution of ceramide in the intraluminal membrane lipid bilayer, favoring its retention in the outer leaflet that results in increased acid ceramidase activity in the late endosome/lysosome, facilitating ceramide deacylation to sphingosine leading to the sequestration of free cholesterol in lysosomes. In addition regulates amyloid-beta production either by activating a signaling pathway that regulates amyloid precursor protein transcription through the modulation of sphingolipid metabolism or through its role in gamma-secretase processing of APP. May play a role in myelin formation.
  • 基因功能參考文獻：
    1. The analyses results suggested ABCA2 mRNA expression was upregulated significantly in AD compared with controls in all datasets. PMID: 29224028
    2. Our findings indicate a considerable and direct relationship between mRNA expression levels of ABCA2, ABCA3, MDR1, and MRP1 genes and positive minimal residual disease (MRD) measured after one year of treatment. PMID: 24145140
    3. Down-regulation of the ATP-binding cassette transporter 2 (Abca2) reduces amyloid-beta production by altering Nicastrin maturation and intracellular localization. PMID: 22086926
    4. SLC2A1/GLUT1, SLC1A3/EAAT1, and SLC1A2/EAAT2 were the main SLC proteins whereas ABCG2/BCRP, ABCB1/MDR1, ABCA2 and ABCA8 were the main ABC quantified in isolated brain microvessels PMID: 21707071
    5. A possible biochemical mechanism links ABCA2 expression, amyloid precursor protein processing, and Alzheimer's disease. PMID: 20704561
    6. we demonstrate that ABCA2-deficiency inhibits prostate tumor metastasis in vivo and decreases chemotactic potential of cells PMID: 21041019
    7. roles for this largest known ABC protein in neural transmembrane lipid export PMID: 12363033
    8. Reciprocal regulation of expression of the ABCA2 promoter by the early growth response-1 and Sp-family transcription factors. PMID: 12560508
    9. It is likely that expression of ABCA2 by two independent promoters constitutes locus of regulation controlling expression of the protein to meet requirements in different tissues. PMID: 15093135
    10. Increased expression of ABCA2 may be causally linked with altered expression of genes associated with the pathogenesis of Alzheimer disease. PMID: 15155565
    11. Among the 45 ABCA2 single nucleotide polymorphisms(SNPs) we tested, one synonymous SNP (rs908832) was found significantly associated with AD in both samples. PMID: 15649702
    12. the expression patterns of ABCA2 in combination with other markers showed phenotypic heterogeneity in schwannomas PMID: 15850583
    13. Data suggest that ABCA2 may exert population-dependent effects on the genetic risk for sporadic Alzheimer's disease and support a role of ABC lipid transporters in the pathogenesis of this disease. PMID: 16752360
    14. No association of ABCA2 Single Nucleotide Polymorphism on chromosome 9 with Alzheimer's disease. PMID: 18336955

    顯示更多

    收起更多

  • 亞細胞定位：
    Endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein.
  • 蛋白家族：
    ABC transporter superfamily, ABCA family
  • 組織特異性：
    [Isoform 3]: Highly expressed in the brain,peripheral blood leukocytes and ovary, whereas lower levels of expression is observed in kidney and liver.; [Isoform 4]: Weakly expressed in brain and highly in peripheral blood leukocytes.
  • 數據庫鏈接：

    HGNC: 32

    OMIM: 600047

    KEGG: hsa:20

    STRING: 9606.ENSP00000344155

    UniGene: Hs.421202



主站蜘蛛池模板： 色老头精品午夜福利视频| 亚洲国产综合无码一区 | 人人妻人人澡人人爽不卡视频| 国产97在线 | 中文| 国产乱人伦av在线a更新| 97se亚洲国产综合自在线| 国产性色αv视频免费| 欧美午夜特黄aaaaaa片| av天堂永久资源网亚洲高清| 人妻精品久久无码区| 小泽玛利亚一区二区在线观看 | 中文字幕av无码一区二区三区电影 | 午夜高清国产拍精品| 亚洲丁香五月天缴情综合| 精品人妻少妇一区二区三区不卡| 综合激情久久综合激情| 美女露出奶头扒开尿口视频直播| 日韩丰满少妇无码内射| 亚洲午夜性猛春交xxxx| 欧美香蕉爽爽人人爽| 国产人妻人伦精品久久久| 欧洲吸奶大片在线看| 久久久精品久久久久久96| 激烈的性高湖波多野结衣| 国产精品人人做人人爽| 日韩激情无码免费毛片| 最近中文字幕免费mv在线视频| 日韩人妻ol丝袜av一二区| 一本一本久久aa综合精品| 午夜福利麻豆国产精品| 狠狠色丁香久久婷婷综合_中| 日本特黄特色aaa大片免费| 国产偷国产偷亚洲清高| 中文字幕无码热在线视频| 国偷自产视频一区二区久| 国产农村妇女精品一二区| 亚洲乱码卡一卡二卡新区中国 | 2020久热爱精品视频在线观看| 欧洲成人一区二区三区| 色欲天天婬色婬香综合网完整版 | 免费又黄又爽又猛的毛片|