在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human AT-rich interactive domain-containing protein 1B (ARID1B), partial

Recombinant Human AT-rich interactive domain-containing protein 1B (ARID1B), partial

  • 中文名稱：
    Recombinant Human AT-rich interactive domain-containing protein 1B(ARID1B) ,partial
  • 貨號：
    CSB-YP822780HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human AT-rich interactive domain-containing protein 1B(ARID1B) ,partial
  • 貨號：
    CSB-EP822780HU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human AT-rich interactive domain-containing protein 1B(ARID1B) ,partial
  • 貨號：
    CSB-EP822780HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human AT-rich interactive domain-containing protein 1B(ARID1B) ,partial
  • 貨號：
    CSB-BP822780HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human AT-rich interactive domain-containing protein 1B(ARID1B) ,partial
  • 貨號：
    CSB-MP822780HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    ARID1B; BAF250B; DAN15; KIAA1235; OSA2AT-rich interactive domain-containing protein 1B; ARID domain-containing protein 1B; BRG1-associated factor 250b; BAF250B; BRG1-binding protein hELD/OSA1; Osa homolog 2; hOsa2; p250R
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. Binds DNA non-specifically.
  • 基因功能參考文獻：
    1. We report on a 4-year-old male child who was found to be heterozygous for ARID1B de novo pathogenic NM_020732.3:c.3323_3324delAA; p.(Lys1108Argfs) mutation. The coding region (+/-5 bp) of the SWI/SNF complex genes showed a de novo heterozygous sequence change in the ARID1B gene: NM_020732.3:c.3323_3324delAA; p.(Lys1108Argfs). The variant was confirmed by Sanger sequencing and was not detected in the parental samples. PMID: 29864107
    2. the correlation between the loss of ARID1A immunoreactivity and reduced ARID1B levels indicates that ARID1B could be an attractive target for anti-cancer therapy. PMID: 29890703
    3. findings establish mutations in ARID1B as the underlying genetic defect in the HHID syndrome in two of three patients. PMID: 28323383
    4. The authors find that ARID1A has a dominant role in maintaining chromatin accessibility at enhancers, while the contribution of ARID1B is evident only in the context of ARID1A mutation. PMID: 28967863
    5. we identified a subgroup of neuroblastoma with ARID1B mutation shows an aggressive behavior. These findings may provide a new biomarker to identify another subgroup of neuroblastoma with high-risk features. PMID: 28521285
    6. these results highlighted the significant genetic contribution of the ARID1B variant, rs73013281, to susceptibility for HCC, especially in interaction with physical activity. PMID: 28415691
    7. we identified concurrent ARID1A and ARID1B inactivating mutations with consequent loss of protein expression in the undifferentiated component of approximately one-quarter of dedifferentiated endometrial and ovarian carcinomas PMID: 27562491
    8. Of the 34 undifferentiated endometrial carcinomas examined, 17 (50%) exhibited SWI/SNF complex inactivation, with 11 tumors showing complete loss of both ARID1A and ARID1B, 5 showing complete loss of BRG1 and 1 showing complete loss of INI1. Ten of the remaining 17 undifferentiated carcinomas showed the following alterations: 5 tumors (15%) showed loss of ARID1A only with intact ARID1B, BRG1, and INI1 expression. PMID: 28863077
    9. We report here the clinical, genetic, and proteomic phenotypes of an individual with a unique apparent de novo mutation of ARID1B due to an intragenic duplication PMID: 28691782
    10. HSCR was observed in a patient with a truncating mutation in ARID1B, further expanding the phenotypic spectrum of Coffin-Siris syndrome. This suggests that the BAF complex does not only play a role in the enteric system of Drosophila, but also in humans. PMID: 27511161
    11. Case Report: Melanotic Xp11 renal cell carcinoma with ARID1B-TFE3 gene fusion. PMID: 28877054
    12. The clinical features of both patients are felt to be consistent with an ARID1B-related disorder. To our knowledge, this is the first report of a pathogenic mutation in ARID1B being passed from an affected parent to their offspring. PMID: 27570168
    13. We report two teenagers with ID whose molecular diagnosis of a SMARC2A or ARID1B mutation, respectively, was established through clinical exome analysis. PMID: 27112773
    14. The ARID1B gene, commonly mutated in multiple types of cancer, was identified as an additional ZNF384 gene fusion partner. PMID: 27392123
    15. knockdown of the SWI/SNF component ARID1B prevents OIS and cooperates with RAS to induce liver tumors PMID: 27737960
    16. Chromosome analysis by array-CGH revealed a small interstitial 6q deletion spanning approximately 1.1 Mb of DNA and containing only one coding gene, ARID1B. We suggest that ARID1B is the key gene behind 6q microdeletion syndrome, and we discuss its possible role in the phenotypic manifestations PMID: 26754677
    17. Gonadal mosaicism in ARID1B gene causes intellectual disability and dysmorphic features in three siblings. PMID: 26395437
    18. ARID1B potentially serves as a valuable prognostic and predictive biomarker as well as a therapeutic target in breast cancer. PMID: 25817822
    19. This study demonstrate that ARID1B is required for neuronal differentiation in the developing brain, such as in dendritic arborization and synapse formation. PMID: 26937011
    20. De novo mutations in ARID1B associated with both syndromic and non-syndromic short stature PMID: 26376624
    21. Results show the crystal structure and binding site of SWI1 protein and identify loop L1 and L2 regions of SWI1 ARID likely play key roles in ARID-DNA interactions. PMID: 26223912
    22. ARID1B role in genome-wide transcriptional regulation by SWI/SNF complexes. PMID: 26716708
    23. This study provide the evidence ARID1B mutation releate to Autism Spectrum Disorder. PMID: 26637798
    24. Chromatin-Remodeling-Factor ARID1B Represses Wnt/beta-Catenin Signaling. PMID: 26340334
    25. BAF complex gene ARID1B is mutated in Coffin-Siris syndrome patients. PMID: 25081545
    26. Phenotype of Coffin-Siris syndrome patients with ARID1B mutations PMID: 25169814
    27. The most prominent and consistent clinical findings in patients with ARID1B haploinsufficiency are developmental delay, speech impairment and intellectual disability. PMID: 25250687
    28. SMARCB1, SMARCA4, or ARID1B were mutated in 20 out of 49 Coffin-Siris syndrome patients. PMID: 23815551
    29. Mutations in ARID1B gene is associated with microsatellite unstable colorectal cancer. PMID: 24382590
    30. The BAF complex, including both ARID1A and ARID1B, contributes to DNA repair and cellular resistance to ionizing radiation and cisplatin. PMID: 24788099
    31. Loss of ARID1B gene is associated with Waldenstrom macroglobulinemia. PMID: 24366360
    32. loss of ARID1A and ARID1B alleles cooperatively promotes cancer formation but also results in a unique functional dependence PMID: 24562383
    33. associations revealed between genetic polymorphisms located in the flanking region of the ARID1B genes and hypoesthesia PMID: 23834954
    34. A possible tumour-suppressor function for ARID1B in pancreatic cancer. PMID: 23660946
    35. ARID1B is important in human brain development and function in general, and in the development of CC and in speech development in particular. PMID: 21801163
    36. Identification of recurrent somatic mutations in the chromatin-remodeling gene ARID1B in the childhood cancer neuroblastoma. PMID: 23202128
    37. Haploinsufficiency of ARID1B, a member of the SWI/SNF-A chromatin-remodeling complex, is a common cause of ID. PMID: 22405089
    38. these results indicate that haploinsufficiency of the ARID1B gene, which encodes an epigenetic modifier of chromatin structure, is an important cause of CSS and is potentially a common cause of intellectual disability and speech impairment. PMID: 22426309
    39. For a number of genes affected by de novo copy number variants CNVs in autism (CNTNAP2, ZNF214, ARID1B, Proline Dehydrogenase), reduced transcript expression may be a mechanism of pathogenesis during neurodevelopment. PMID: 21448237
    40. Cloning and characterization of hELD/OSA1, a novel BRG1 interacting protein. PMID: 11988099
    41. 6A3-5 expression is associated with alpha-smooth muscle cell actin in mesangial cells, arteriolar smooth muscle cells, and interstitial myofibroblasts.could potentially be a novel early vascular marker of acute and chronic renal ischemic stress PMID: 14633620
    42. Analysis of DNA-binding behaviour indicates that ARID1B binds DNA in a non-sequence-specific manner similar to ARID1A PMID: 15170388
    43. The chromatin remodeling factor ARID1B had a very similar pattern of expression with an incremental increase in HPFH and decreased expression in deltabeta-thalassemia. PMID: 16952470
    44. A subset of mammalian SWI/SNF complexes, specifically including the ARID1B subunit, is required for efficient cell cycle re-entry and for the association of activating factors with the c-myc promoter. PMID: 17255939

    顯示更多

    收起更多

  • 相關(guān)疾病：
    Coffin-Siris syndrome 1 (CSS1)
  • 亞細胞定位：
    Nucleus.
  • 組織特異性：
    Widely expressed with high levels in heart, skeletal muscle and kidney.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 18040

    OMIM: 135900

    KEGG: hsa:57492

    STRING: 9606.ENSP00000344546

    UniGene: Hs.291587



主站蜘蛛池模板： 国产精品自在拍首页视频| 国产美女嘘嘘嘘嘘嘘| 国产精品毛片在线完整版| 国产办公室秘书无码精品99| 欧美 日韩 国产 成人 在线观看| 在线观看老湿视频福利| av怡红院一区二区三区| 亚洲色欲久久久久综合网| 国产aⅴ视频免费观看| 亚洲 小说 欧美 另类 社区| 99er热精品视频| 4hu四虎永久免费地址ww416| 亚洲精品久久久一二三区| 人妻少妇精品视中文字幕国语| 少妇愉情理伦片丰满丰满| 无码熟妇αⅴ人妻又粗又大| 欧性猛交ⅹxxx乱大交| 日韩高清成片免费视频| 国产最大成人亚洲精品| 男女做爰猛烈叫床视频免费| 波多野结衣久久一区二区| 无码精品国产一区二区免费| 亚洲欧洲中文日韩乱码av| 国产精品视频永久免费播放| 色爱区综合五月激情| 日韩亚洲中字无码一区二区三区| 亚洲成aⅴ人最新无码| 国产乱人伦无无码视频试看| 亚洲中文字幕无码爆乳app| 欧美级特黄aaaaaa片| 中国猛少妇色xxxxx| 亚洲 另类 熟女 字幕| 国产精品久久久久久成人影院| 国产精品午夜爆乳美女视频| 四虎www成人影院观看| 国产日韩精品中文字无码| 久久香蕉综合色一综合色88| 亚洲人成电影网站在线播放| 无码一区二区| 丰满少妇高潮惨叫久久久一| 国产午夜高清高清在线观看|