在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human AP-2 complex subunit beta (AP2B1), partial

  • 中文名稱:
    Recombinant Human AP-2 complex subunit beta(AP2B1) ,partial
  • 貨號(hào):
    CSB-YP001871HU
  • 規(guī)格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    Recombinant Human AP-2 complex subunit beta(AP2B1) ,partial
  • 貨號(hào):
    CSB-EP001871HU
  • 規(guī)格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    Recombinant Human AP-2 complex subunit beta(AP2B1) ,partial
  • 貨號(hào):
    CSB-EP001871HU-B
  • 規(guī)格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    Recombinant Human AP-2 complex subunit beta(AP2B1) ,partial
  • 貨號(hào):
    CSB-BP001871HU
  • 規(guī)格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    Recombinant Human AP-2 complex subunit beta(AP2B1) ,partial
  • 貨號(hào):
    CSB-MP001871HU
  • 規(guī)格:
  • 來源:
    Mammalian cell
  • 其他:

產(chǎn)品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    Adapter related protein complex 2 beta 1 subunit; Adapter-related protein complex 2 beta subunit; Adaptin, beta 2 (beta); Adaptor protein complex AP-2 subunit beta; Adaptor related protein complex 2, beta 1 subunit; ADTB2; AP-2 complex subunit beta; AP105B; AP2 BETA; Ap2b1; AP2B1_HUMAN; Beta adaptin; Beta-2-adaptin; Beta-adaptin; Beta2 adaptin; CLAPB1; Clathrin assembly protein complex 2 beta large chain; Clathrin associated/assembly/adaptor protein, large, beta 1; DKFZp781K0743; Plasma membrane adaptor HA2/AP2 adaptin beta subunit
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長(zhǎng)度:
    Partial
  • 蛋白標(biāo)簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng):
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. During long-term potentiation in hippocampal neurons, AP-2 is responsible for the endocytosis of ADAM10. The AP-2 beta subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins; at least some clathrin-associated sorting proteins (CLASPs) are recognized by their [DE]-X(1,2)-F-X-X-[FL]-X-X-X-R motif. The AP-2 beta subunit binds to clathrin heavy chain, promoting clathrin lattice assembly; clathrin displaces at least some CLASPs from AP2B1 which probably then can be positioned for further coat assembly.
  • 基因功能參考文獻(xiàn):
    1. this study determined a structure of AP2 that includes the clathrin-binding beta2 hinge. PMID: 25061211
    2. Results suggest that autosomal recessive hypercholesterolemia (ARH) and beta-arrestin depend on a privileged AP2beta2 appendage site for proper cargo recruitment to clathrin bud sites. PMID: 18843039
    3. multiple interactions between PIPKI gamma-p90 and AP-2 lead to spatiotemporally controlled PI(4,5)P(2) synthesis during clathrin-mediated synaptic vesicle endocytosis PMID: 19903820
    4. interactions of the EGF receptor with AP-2 mediated by the receptor 974YRAL and di-leucine motifs may contribute to beta2 tyrosine phosphorylation PMID: 12900408
    5. AP2 regulates thrombin receptor constitutive internalization and endothelial cell resensitization. PMID: 16581796
    6. Clathrin, which interacts with the AP2beta-appendage, achieves ligand displacement in vivo by self-polymerisation as the coated pit matures. PMID: 16903783
    7. EGFR, fibrillin-2, P-cadherin and AP2beta as biomarkers for rhabdomyosarcoma diagnostics. PMID: 19469909

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Cell membrane. Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side. Note=AP-2 appears to be excluded from internalizing CCVs and to disengage from sites of endocytosis seconds before internalization of the nascent CCV.
  • 蛋白家族:
    Adaptor complexes large subunit family
  • 組織特異性:
    Expressed in the brain (at protein level).
  • 數(shù)據(jù)庫鏈接:

    HGNC: 563

    OMIM: 601025

    KEGG: hsa:163

    STRING: 9606.ENSP00000314414

    UniGene: Hs.514819



主站蜘蛛池模板: 亚洲人成无码网www动漫| 国产成人无码免费视频在线 | 人妻体内射精一区二区三区 | 亚洲人午夜射精精品日韩| 岛国4k人妻一区二区三区| 在线天堂免费观看.www| 人妻 校园 激情 另类| 又紧又大又爽精品一区二区| 国产av高清无亚洲| 自偷自拍亚洲综合精品麻豆 | 人妻少妇邻居少妇好多水在线| 东京热无码一区二区三区av| 一区二区三区无码免费看| 色婷婷美国农夫综合激情亚洲| 亚洲精品熟女国产| 久拍国产在线观看| 成人免费无码大片a毛片抽搐| 婷婷四房播播| 国产综合精品久久丫| 国产人在线成免费视频| 色在线 | 国产| 亚洲精品久久久久久下一站| 国产精品免费无遮挡无码永久视频| 亚洲一区波多野结衣在线| 成人无码a∨电影免费| 久久综合给合久久狠狠狠97色| 少妇精品导航| 最近高清中文在线字幕在线观看1| 日本高清视频wwww色| 亚洲乱亚洲乱少妇无码99p| 亚洲精品色情aⅴ色戒| 精品亚洲aⅴ在线无码播放| 性xxxx视频播放免费| а√天堂8资源中文在线| 国产无遮挡又黄又爽奶头| 极品美女扒开粉嫩小泬| 亚洲色大成网站www永久网站| 免费无码观看的av在线播放| 亚洲v天堂v手机在线| 成人毛片无码一区二区三区| 十八禁真人啪啪免费网站|