在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

AP2B1 Antibody

  • 中文名稱:
    AP2B1兔多克隆抗體
  • 貨號:
    CSB-PA001871GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    Adapter related protein complex 2 beta 1 subunit antibody; Adapter-related protein complex 2 beta subunit antibody; Adaptin, beta 2 (beta) antibody; Adaptor protein complex AP-2 subunit beta antibody; Adaptor related protein complex 2, beta 1 subunit antibody; ADTB2 antibody; AP-2 complex subunit beta antibody; AP105B antibody; AP2 BETA antibody; Ap2b1 antibody; AP2B1_HUMAN antibody; Beta adaptin antibody; Beta-2-adaptin antibody; Beta-adaptin antibody; Beta2 adaptin antibody; CLAPB1 antibody; Clathrin assembly protein complex 2 beta large chain antibody; Clathrin associated/assembly/adaptor protein, large, beta 1 antibody; DKFZp781K0743 antibody; Plasma membrane adaptor HA2/AP2 adaptin beta subunit antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human AP2B1
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IF
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. During long-term potentiation in hippocampal neurons, AP-2 is responsible for the endocytosis of ADAM10. The AP-2 beta subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins; at least some clathrin-associated sorting proteins (CLASPs) are recognized by their [DE]-X(1,2)-F-X-X-[FL]-X-X-X-R motif. The AP-2 beta subunit binds to clathrin heavy chain, promoting clathrin lattice assembly; clathrin displaces at least some CLASPs from AP2B1 which probably then can be positioned for further coat assembly.
  • 基因功能參考文獻:
    1. this study determined a structure of AP2 that includes the clathrin-binding beta2 hinge. PMID: 25061211
    2. Results suggest that autosomal recessive hypercholesterolemia (ARH) and beta-arrestin depend on a privileged AP2beta2 appendage site for proper cargo recruitment to clathrin bud sites. PMID: 18843039
    3. multiple interactions between PIPKI gamma-p90 and AP-2 lead to spatiotemporally controlled PI(4,5)P(2) synthesis during clathrin-mediated synaptic vesicle endocytosis PMID: 19903820
    4. interactions of the EGF receptor with AP-2 mediated by the receptor 974YRAL and di-leucine motifs may contribute to beta2 tyrosine phosphorylation PMID: 12900408
    5. AP2 regulates thrombin receptor constitutive internalization and endothelial cell resensitization. PMID: 16581796
    6. Clathrin, which interacts with the AP2beta-appendage, achieves ligand displacement in vivo by self-polymerisation as the coated pit matures. PMID: 16903783
    7. EGFR, fibrillin-2, P-cadherin and AP2beta as biomarkers for rhabdomyosarcoma diagnostics. PMID: 19469909

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane. Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side. Note=AP-2 appears to be excluded from internalizing CCVs and to disengage from sites of endocytosis seconds before internalization of the nascent CCV.
  • 蛋白家族:
    Adaptor complexes large subunit family
  • 組織特異性:
    Expressed in the brain (at protein level).
  • 數據庫鏈接:

    HGNC: 563

    OMIM: 601025

    KEGG: hsa:163

    STRING: 9606.ENSP00000314414

    UniGene: Hs.514819



主站蜘蛛池模板: 国内精品久久久久伊人av| 午夜成人无码福利免费视频| 成年美女黄网站色奶头大全| 久久综合色鬼综合色| 精品国产你懂的在线观看| 视频久re精品在线观看| 无套中出丰满人妻无码| 国产精品久久久亚洲| 国产 | 欧洲野花视频欧洲1| 狠狠色噜噜狠狠狠777米奇888| 韩国日本三级在线观看| 日本精品久久久久中文字幕 | 色欲久久综合亚洲精品蜜桃| 中文午夜人妻无码看片| 99久热re在线精品99 6热视频| 热久久美女精品天天吊色| 国产自偷在线拍精品热| 夜夜爱夜鲁夜鲁很鲁| 精品人妻一区二区三区浪潮在线| 亚洲精品无人区| 亚洲色欲在线播放一区| 亚洲人ⅴsaⅴ国产精品| 精品无码中文视频在线观看| 无码国模产在线观看免费| 无码骚夜夜精品| 五月av综合av国产av| 国产熟女精品视频大全| 污污网站18禁在线永久免费观看| 曰本av中文字幕一区二区| 国产无遮挡又爽又刺激的视频老师| 日日橹狠狠爱欧美视频| 自拍偷在线精品自拍偷免费| 奇米影视第四色首页| 99在线精品一区二区三区| 免费人成视频在线播放视频 | 国产无套露脸在线观看| 窝窝午夜精品一区二区| 国产破外女出血视频| 男人女人做爽爽18禁网站| 国产韩国精品一区二区三区久久| 国产成人a区在线观看|