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  4. Recombinant Human AF4/FMR2 family member 3 (AFF3), partial

Recombinant Human AF4/FMR2 family member 3 (AFF3), partial

  • 中文名稱：
    Recombinant Human AF4/FMR2 family member 3(AFF3) ,partial
  • 貨號：
    CSB-YP001414HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human AF4/FMR2 family member 3(AFF3) ,partial
  • 貨號：
    CSB-EP001414HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human AF4/FMR2 family member 3(AFF3) ,partial
  • 貨號：
    CSB-EP001414HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human AF4/FMR2 family member 3(AFF3) ,partial
  • 貨號：
    CSB-BP001414HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human AF4/FMR2 family member 3(AFF3) ,partial
  • 貨號：
    CSB-MP001414HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    AFF3
  • Uniprot No.：
  • 別名：
    AF4/FMR2 family member 3; AFF3; AFF3_HUMAN; LAF4; Lymphoid nuclear protein 4; Lymphoid nuclear protein related to AF4; MLLT2 like; MLLT2 related protein; Protein LAF-4
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Putative transcription activator that may function in lymphoid development and oncogenesis. Binds, in vitro, to double-stranded DNA.
  • 基因功能參考文獻：
    1. Data identified AFF3 as an interactive protein with beclin1 and suggest that AFF3 is probably a key regulator of Beclin-1. PMID: 28401970
    2. Both the AFF3 and NTM triglyceride associations were replicated among Multi-ethnic Study of Atherosclerosis study participants (P = 1.00 x 10(-7) and 8.00 x 10(-5), respectively). PMID: 25819087
    3. FRA2A-expressing individuals have mosaic expansions of the AFF3 CGG repeat. PMID: 24763282
    4. Significant evidence for association of AFF3 rs10865035 with systgemic lupus erythmatgosus was detected. PMID: 22983539
    5. overexpression of AFF2/3/4 interferes with the organization and/or biogenesis of nuclear speckles. PMID: 21330300
    6. The LAF4 gene mapped on chromosome region 2q11.2-q12 has been identified as a fusion partner of the MLL gene in a case of infant acute lymphoblastic leukemia. PMID: 12203795
    7. This gene is fused to MLL in childhood acute lymphoblastic leukemia with t(2;11)(q11;q23). PMID: 12743608
    8. LAF-4 may be a proto-oncogene that is transcriptionally activated in some cases of breast cancer. PMID: 15704140
    9. array comparative genomic hybridization (CGH) analysis revealed a de novo interstitial microdeletion of 500 kb on chromosome 2q11.1 containing the LAF4/AFF3 (lymphoid-nuclear-protein-related AF4) gene PMID: 18616733
    10. A novel fusion 5'AFF3/3'BCL2 originated from a t(2;18)(q11.2;q21.33) translocation in follicular lymphoma. PMID: 18622426
    11. AFF3 is a novel rheumatoid arthritis susceptibile gene. PMID: 19359276

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  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    AF4 family
  • 組織特異性：
    Preferentially expressed in lymphoid tissues, highest levels being found in the thymus.
  • 數據庫鏈接：

    HGNC: 6473

    OMIM: 601464

    KEGG: hsa:3899

    STRING: 9606.ENSP00000348793

    UniGene: Hs.444414



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